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CAS No.: | 16984-48-8 | |
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Name: | FLUORIDE STANDARD | |
Article Data: | 212 | |
Molecular Structure: | ||
Formula: | F | |
Molecular Weight: | 18.9984 | |
Synonyms: | Fluorideion; Fluoride ion (F-); Fluoride ion(1-); Fluoride(1-); Fluorine ion(1-);Fluorine ion(F1-); Fluorine, ion; Hydrofluoric acid, ion(1-); Perfluoride | |
Density: | 1.000 g/cm3 (20 °C) | |
Melting Point: | 135℃ | |
Solubility: | Immiscible with water. | |
Safety: | Human poison by ingestion. Human systemic effects by ingestion: convulsions, changes in the respiratory system, liver, and kidneys. Mutation data reported. When heated to decomposition it emits toxic fumes of F−. | |
Analytical Methods: | For occupational chemical analysis use NIOSH: Fluorides 7902; Fluoride in Urine 8308. |
|
PSA: | 0.00000 | |
LogP: | -2.99600 |
IUPAC Name: Fluoride
Molecular Formula: F-
Molecular Weight: 19 g/mol
Canonical SMILES: [F-]
InChI: InChI=1S/FH/h1H/p-1
Product Categories: Intermediates
Classification Code: Human Data; Mutation data; Reproductive Effect
Fluoride reagents are significant in synthetic organic chemistry. Due to the affinity of silicon for fluoride, and the ability of silicon to expand its coordination number, silyl ether protecting groups can be easily removed by the fluoride sources such as sodium fluoride and tetra-n-butylammonium fluoride (TBAF).
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
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human | LDLo | oral | 50mg/kg (50mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LIVER: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES | IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 237, 1982. |
human | TDLo | oral | 3mg/kg (3mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LIVER: OTHER CHANGES | IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 237, 1982. |
mouse | LD50 | intravenous | 22800ug/kg (22.8mg/kg) | Microvascular Research. Vol. 8, Pg. 320, 1974. |
EPA Genetic Toxicology Program.
Human poison by ingestion. Human systemic effects by ingestion: convulsions, changes in the respiratory system, liver, and kidneys. Mutation data reported. When heated to decomposition it emits toxic fumes of F−.
Fluoride-containing compounds are so diverse that it is not possible to generalize on their toxicity, which depends on their reactivity and structure, and in the case of salts, their solubility and ability to release fluoride ions.Reaction of the irreversible inhibitor diisopropylfluorophosphate with a serine proteaseSoluble fluoride salts, of which NaF is the most common, are mildly toxic but have resulted in both accidental and suicidal deaths from acute poisoning.While the minimum fatal dose in humans is not known, a case of a fatal poisoning of an adult with 4 grams of NaF is documented.Sodium fluorosilicate For Na2SiF6, the 50% lethal dose (LD50) orally in rats is 0.125 g/kg, corresponding to 12.5 for a 100 kg adult.
OSHA PEL: TWA 2.5 mg(F)/m3
ACGIH TLV: TWA 2.5 mg(F)/m3; BEI: 3 mg/g creatinine of fluorides in urine prior to shift; 10 mg/g creatinine of fluorides in urine at end of shift.
DFG MAK: 2.5 mg/m3
NIOSH REL: (Fluorides, inorganic) TWA 2.5 mg(F)/m3
For occupational chemical analysis use NIOSH: Fluorides 7902; Fluoride in Urine 8308.
Fluoride (CAS NO.16984-48-8), its Synonyms are Drinking water, fluoride treated ; Fluoride as dust ; Fluoride dust ; Fluoride ion(1-) ; Fluoride ion(F-) ; Fluoride(1-) ; Fluorine ion ; Fluorine ion(1-) . Fluoride is the anion F-, the reduced form of fluorine. Both organic and inorganic compounds containing the element fluorine are sometimes called fluorides. Fluoride, like other halides, is a monovalent ion (-1 charge). Its compounds often have properties that are distinct relative to other halides. Structurally, and to some extent chemically, the fluoride ion resembles the hydroxide ion. Fluorine-containing compounds range from potent toxins such as sarin to life-saving pharmaceuticals such as efavirenz, and from inert materials such as calcium fluoride to the highly reactive sulfur tetrafluoride. The range of fluorine-containing compounds is considerable as fluorine is capable of forming compounds with all the elements except helium and neon.