CAS No.171714-84-4,Darusentan Suppliers

Products Categories

Pharmaceutical (24)
Organic Chemicals (5)
Others (3)

Basic Information

Molecular Structure:
CAS No.:	171714-84-4
Name:	Darusentan
Article Data:	5

Formula:	C₂₂H₂₂N₂O₆
Molecular Weight:	410.426
Synonyms:	Benzenepropanoicacid, a-[(4,6-dimethoxy-2-pyrimidinyl)oxy]-b-methoxy-b-phenyl-, (S)-;
Density:	1.269 g/cm³
Boiling Point:	587.307 °C at 760 mmHg
Flash Point:	308.993 °C
PSA:	100.00000
LogP:	2.91600

Country:
- China (Mainland)(31)
- United States(1)
Business Type:
All

Lab/Research institutions

Trading Company

Manufacturers

Other
Certificate:
Manufacturer

Enterprise Authentication

ISO

GMP

FDA

HALAL

Display:default sort
Suppiers of more reward points first

New supplier

Total:31 Page 1 of 1 1

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 171714-84-4

History

Darusentan's application in the cancer field is licensed by Myogen in June 2003. In May 2007, a randomized, double-blind, active control, parallel assignment, safety and efficacy phase III trial was initiated in subjects who had completed the maintenance period of the DAR-312 study.

Specification

The Darusentan, with the CAS registry number 171714-84-4, is also known as (2S)-2-[(4,6-Dimethoxy-2-pyrimidinyl)oxy]-3-methoxy-3,3-diphenylpropanoic acid. This chemical's molecular formula is C₂₂H₂₂N₂O₆ and molecular weight is 410.42. What's more, its IUPAC name is called (2S)-2-(4,6-Dimethoxypyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid. This chemical is a endothelin receptor antagonist.

Physical properties about Darusentan are: (1)ACD/LogP: 1.456; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.00; (4)ACD/LogD (pH 7.4): -2.29; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 8; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 9; (12)Polar Surface Area: 100 Å²; (13)Index of Refraction: 1.583; (14)Molar Refractivity: 108.095 cm³; (15)Molar Volume: 323.423 cm³; (16)Polarizability: 42.852×10^-24cm³; (17)Surface Tension: 50.468 dyne/cm; (18)Density: 1.269 g/cm³; (19)Flash Point: 308.993 °C; (20)Enthalpy of Vaporization: 92.234 kJ/mol; (21)Boiling Point: 587.307 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25 °C.

You can still convert the following datas into molecular structure:
(1) SMILES: O=C(O)[C@@H](Oc1nc(OC)cc(OC)n1)C(OC)(c2ccccc2)c3ccccc3
(2) InChI: InChI=1S/C22H22N2O6/c1-27-17-14-18(28-2)24-21(23-17)30-19(20(25)26)22(29-3,15-10-6-4-7-11-15)16-12-8-5-9-13-16/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1
(3) InChIKey: FEJVSJIALLTFRP-LJQANCHMSA-N