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171714-84-4

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171714-84-4 Usage

General Description

Darusentan is a selective endothelin receptor antagonist that is predominantly used in the field of pharmacology. It specifically targets the endothelin receptor A to prevent the action of endothelin-1, a type of peptide that constricts blood vessels and raises blood pressure. This makes Darusentan an effective drug in treating conditions such as pulmonary hypertension and kidney diseases. Its usage, however, can have side effects including fluid retention or headaches. Darusentan was developed by Gilead Sciences but its current status remains experimental, not having received US Food and Drug Administration approval.

Check Digit Verification of cas no

The CAS Registry Mumber 171714-84-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,1,7,1 and 4 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 171714-84:
(8*1)+(7*7)+(6*1)+(5*7)+(4*1)+(3*4)+(2*8)+(1*4)=134
134 % 10 = 4
So 171714-84-4 is a valid CAS Registry Number.
InChI:InChI=1/C22H22N2O6/c1-27-17-14-18(28-2)24-21(23-17)30-19(20(25)26)22(29-3,15-10-6-4-7-11-15)16-12-8-5-9-13-16/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1

171714-84-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-2-(4,6-dimethoxypyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid

1.2 Other means of identification

Product number -
Other names (+)-(S)-2-(4,6-dimethoxy-pyrimidin-2-yloxy)-3-methoxy-3,3-diphenyl-propionic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:171714-84-4 SDS

171714-84-4Downstream Products

171714-84-4Relevant articles and documents

Method for Preparing Optically Pure (+)-Ambrisentan and (+)-Darusentan

-

, (2014/09/16)

Disclosed is a method for preparing optically pure (+)-ambrisentan and (+)-darusentan, comprising: firstly catalyzing the asymmetric epoxidation of a β-unsaturated alkene using a chiral ketone derived from fructose or a hydrate thereof as a catalyst, and then subjecting the product to an epoxy compound ring-opening reaction and substitution reaction successively to obtain optically pure (+)-ambrisentan and (+)-darusentan.

Improved Process For The Preparation Of Endothelin Receptor Antagonists

-

, (2011/11/06)

The present invention relates to improved processes for the preparation of Endothelin receptor antagonists, their salts and intermediates.

Structural similarity and its surprises: Endothelin receptor antagonists -process research and development report

Jansen,Knopp,Amberg,Bernard,Koser,Mueller,Muenster,Pfeiffer,Riechers

, p. 16 - 22 (2013/09/07)

Process research and pilot plant processes are described for three endothelin (ET) receptor antagonists. The efficient synthesis of the parent compound Darusentan proceeds via a Darzens reaction from chloroacetate with benzophenone, addition of methanol to the resulting epoxide, saponification of the alkyl propionate and optical resolution of the racemic acid by crystallisation with a chiral amine. The final stage of the synthetic sequence involves the introduction of a pyrimidine moiety. Intermediates formed during this process can be used as starting materials for the synthesis of the two other ET receptor antagonists BSF 420627 and BSF 302146. An ether exchange reaction, which replaces the methoxy with a phenethyloxy substituent, enabled BSF 420627 to be prepared. The synthetic route to BSF 302146 employs trimethylaluminum to methylate the epoxide produced by the Darzens reaction.

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