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CAS No.: | 173194-95-1 |
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Name: | 6-HYDROXY-2-NAPHTHALENEBORONIC ACID |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C10H9BO3 |
Molecular Weight: | 187.991 |
Synonyms: | (6-Hydroxynaphthalen-2-yl)boronic acid;Boronic acid,(6-hydroxy-2-naphthalenyl)- (9CI); |
Density: | 1.358 g/cm3 |
Melting Point: | 218-224 °C |
Boiling Point: | 458.567 °C at 760 mmHg |
Flash Point: | 231.134 °C |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-36/37/39 |
PSA: | 60.69000 |
LogP: | 0.22520 |
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A review of luminescent assays has been published by L. J. Kricka, Clinical Chemistry 37, 1472-1481 (1991).
SUMMARY OF THE INVENTION
It has now been found that certain organoboron compounds are effective enhancers of chemiluminescence in a reaction between a dihydrophthalaztnedione (DPD), a peroxidase enzyme catalyst and an oxidant. The enhancers of the present Invention include compounds of formula which R, W, X, Y and Z have the following meanings; R is selected from hydrogen, n-butyl, O,O-propylene (a cyclic ether), 4'-chlorophenyl and 3',5'-dichlorophenyl, W is selected from hydrogen, hydroxy, methyl, methoxy and chloro, X Is selected from hydrogen, methyl, chloro, amino and nitro, Y is selected from hydrogen, methyl, carboxy, chloro, bromo, iodo, phenyl, phenoxy, 4'-chloroanilino, 4'-boronylphenyl, 4'-bromophenyl, 2'-carboxyethenyl and trimethylsilyl, Z is selected from hydrogen, 5-chloro, 5-bromo, 5-(3'-trifluoromethyl)phenylazo, or 6-chloro, W and X together may represent a fused benzene ring and X and Y together may represent a fused benzene ring substituted by hydroxy in the 6 position of the naphthalene ring numbering, provided that