Products Categories
| CAS No.: | 1746-01-6 |
|---|---|
| Name: | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN |
| Article Data: | 31 |
| Molecular Structure: | |
|
|
|
| Formula: | C12H4 Cl4 O2 |
| Molecular Weight: | 321.975 |
| Synonyms: | Dibenzo-p-dioxin,2,3,7,8-tetrachloro- (6CI,7CI,8CI);2,3,7,8-TCDD;2,3,7,8-Tetrachloro-p-dioxin;2,3,7,8-Tetrachlorodibenzo-1,4-dioxin;2,3,7,8-Tetrachlorodibenzo-p-dioxin;2,3,7,8-Tetrachlorodibenzo[b,e][1,4]dioxin;2,3,7,8-Tetrachlorodibenzodioxin;D48;Dioxin;Dioxin (herbicide contaminant);PCDD 48;TCDBD;TCDD;Tetrachlorodibenzo-p-dioxin;Tetrachlorodibenzodioxin; |
| EINECS: | 217-122-7 |
| Density: | 1.643g/cm3 |
| Melting Point: | 295 |
| Boiling Point: | 500(dec) |
| Flash Point: | 164.2°C |
| Solubility: | 0.0000000019g/100mL |
| Hazard Symbols: | F,Xn |
| Risk Codes: | 11-38-48/20-63-65-67 |
| Safety: |
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. One of the most toxic synthetic chemicals. A deadly experimental poison by ingestion, skin contact, and intraperitoneal routes. Human systemic effects by skin contact: allergic dermatitis. Experimental reproductive effects. Human mutation data reported. An eye irritant. TCDD is the most toxic member of the 75 dioxins. It causes death in rats by hepatic cell necrosis. Death can follow a lethal dose by weeks. Acute and subacute exposure result in wasting, hepatic necrosis, thymic atrophy, hemorrhage, lymphoid depletion, chloracne. A by-product of the manufacture of polychlorinated phenols. It is found at low levels in 2,4,5-T, 2,4,5-trichlorophenol, and hexachlorophene. It is also formed during various combustion processes. Incineration of chemical wastes, including chlorophenols, chlorinated benzenes, and biphenyl ethers, may result in the presence of TCDD in flue gases, fly ash, and soot particles. It is immobile in contaminated soil and may be retained for years. TCDD has the potential for bio-accumulation in animals. An accident in Seveso, Italy, and inadvertent soil contamination in Missouri have resulted in abandonment of the contaminated areas. When heated to decomposition it emits toxic fumes of Cl−. |
| PSA: | 18.46000 |
| LogP: | 6.19820 |
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 211914-50-0N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-beta-alanine ethyl ester hydrochloride
- 240444-70-62,3,5,6-Tetrafluor-4-(methoxymethyl)benzyl-2,2-dimethyl-3-(prop-1-en-1-yl)cyclopropancarboxylat
- Total:0 Page 0 of 0
What can I do for you?
Get Best Price
Chemistry
Molecular Struture:
IUPAC Name: 2,3,7,8-Tetrachlorooxanthrene
Synonyms of Tcdd (CAS NO.1746-01-6): 2,3,6,7-Tetrachlorodibenzo-p-dioxin ; 2,3,7,8-Czterochlorodwubenzo-p-dwuoksyny ; 2,3,7,8-czterochlorodwubenzo-p-dwuoksyny(polish) ; 2,3,7,8-TCDD ; 2,3,7,8-Tetrachlorodibenzo(b,e)(1,4)dioxan ; 2,3,7,8-Tetrachlorodibenzo(b,e)(1,4)dioxin ; 2,3,7,8-Tetrachlorodibenzo[b,e][1,4]dioxin ; 2,3,7,8-Tetrachlorodibenzo-1,4-Dioxin
CAS NO: 1746-01-6
Molecular Formula: C12H4Cl4O2
Molecular Weight: 321.97
EINECS: 217-122-7
Mol File: 1746-01-6.mol
Surface Tension: 57.4 dyne/cm
Density: 1.643 g/cm3
Flash Point: 164.2 °C
Enthalpy of Vaporization: 64.54 kJ/mol
Boiling Point: 417.9 °C at 760 mmHg
Vapour Pressure: 8.26E-07 mmHg at 25°C
Index of Refraction: 1.655
Appearance: Tcdd (CAS NO.1746-01-6) is white crystals or tan crystalline powder.
Classification Code
Environmental pollutants: Human Data ; Mutation data ; Noxae ; Reproductive Effect ; Skin / Eye Irritant ; Teratogens ; Tumor data
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| chicken | LDLo | intraperitoneal | 25ug/kg (0.025mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) | Journal of Toxicology and Environmental Health. Vol. 35, Pg. 187, 1992. |
| chicken | LDLo | oral | 25ug/kg (0.025mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Food and Cosmetics Toxicology. Vol. 11, Pg. 585, 1973. |
| dog | LD50 | oral | 1ug/kg (0.001mg/kg) | Experientia. Vol. 38, Pg. 879, 1982. | |
| frog | LD50 | oral | 1mg/kg (1mg/kg) | Scientific American. Vol. 254, Pg. 29, 1986. | |
| guinea pig | LD50 | oral | 500ng/kg (0.0005mg/kg) | Environmental Science Research. Vol. 2, Pg. 708, 1973. | |
| hamster | LD50 | intraperitoneal | > 3mg/kg (3mg/kg) | ENDOCRINE: CHANGES IN THYMUS WEIGHT BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" | Toxicology and Applied Pharmacology. Vol. 55, Pg. 67, 1980. |
| hamster | LD50 | oral | 1157ug/kg (1.157mg/kg) | GASTROINTESTINAL: OTHER CHANGES BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" | Toxicology and Applied Pharmacology. Vol. 55, Pg. 67, 1980. |
| human | TDLo | skin | 107ug/kg (0.107mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER TOPICAL EXPOSURE" | Scientific American. Vol. 254, Pg. 29, 1986. |
| mammal (species unspecified) | LD50 | oral | 4200ng/kg (0.0042mg/kg) | LIVER: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES BLOOD: CHANGES IN SPLEEN | Archives of Environmental Contamination and Toxicology. Vol. 17, Pg. 33, 1988. |
| monkey | LD50 | oral | 2ug/kg (0.002mg/kg) | Experientia. Vol. 38, Pg. 879, 1982. | |
| mouse | LD50 | intraperitoneal | 120ug/kg (0.12mg/kg) | Scientific American. Vol. 254, Pg. 29, 1986. | |
| mouse | LD50 | oral | 114ug/kg (0.114mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: OTHER CHANGES | Toxicology and Applied Pharmacology. Vol. 29, Pg. 229, 1974. |
| mouse | LDLo | skin | 80ug/kg (0.08mg/kg) | GASTROINTESTINAL: OTHER CHANGES | Research Communications in Chemical Pathology and Pharmacology. Vol. 20, Pg. 101, 1978. |
| mouse | LDLo | unreported | 200ug/kg (0.2mg/kg) | LIVER: FATTY LIVER DEGERATION | Annals of the New York Academy of Sciences. Vol. 320, Pg. 204, 1979. |
| rabbit | LD50 | intraperitoneal | 252ug/kg (0.252mg/kg) | Scientific American. Vol. 254, Pg. 29, 1986. | |
| rabbit | LD50 | oral | 115ug/kg (0.115mg/kg) | Toxicology and Applied Pharmacology. Vol. 35, Pg. 553, 1976. | |
| rabbit | LD50 | skin | 275ug/kg (0.275mg/kg) | EHP, Environmental Health Perspectives. Vol. 5, Pg. 87, 1973. | |
| rat | LD50 | intraperitoneal | 24600ng/kg (0.0246mg/kg) | Toxicology and Applied Pharmacology. Vol. 45, Pg. 513, 1978. | |
| rat | LD50 | oral | 20ug/kg (0.02mg/kg) | Experientia. Vol. 38, Pg. 879, 1982. |
Consensus Reports
NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 350.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 15 ,1977,p. 41.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 15 ,1977,p. 41.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NTP Carcinogenesis Bioassay (gavage); Clear Evidence: mouse, rat NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. NTP-TR-209 ,1982. ; (dermal). EPA Genetic Toxicology Program.
Safety Profile
Hazard Codes of Tcdd (CAS NO.1746-01-6): 
F,
Xn
Risk Statements: 11-38-48/20-63-65-67
R11: Highly flammable.
R38: Irritating to skin.
R48: Danger of serious damage to health by prolonged exposure.
R20: Harmful by inhalation.
R63: Possible risk of harm to the unborn child.
R65: Harmful: may cause lung damage if swallowed.
R67: Vapours may cause drowsiness and dizziness.
Safety Statements: 36/37-62
S36/37: Wear suitable protective clothing and gloves.
S62: If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label.
RIDADR: 2811
HazardClass: 6.1(a)
PackingGroup: I
Standards and Recommendations
DFG MAK: Animal Carcinogen, Suspected Human Carcinogen
NIOSH REL: (Dioxin) Reduce to lowest feasible level
Specification
1.Air & Water Reactions of Tcdd (CAS NO.1746-01-6): Insoluble in water.
2.Reactivity Profile: 2,3,7,8-tetrachlorodibenzo-p-dioxin reaacts when exposed to ultraviolet light in solution in isooctane or n-octanol. Undergoes catalytic perchlorination .
3.Fire Hazard :Literature sources indicate that 2,3,7,8-Tetrachlorodibenzo-p-dioxin is nonflammable.