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Basic Information
| CAS No.: | 175277-74-4 | ||||||
|---|---|---|---|---|---|---|---|
| Name: | 2-(AMINOMETHYL)-3-CHLORO-5-(TRIFLUOROMETHYL)-PYRIDINE HYDROCHLORIDE | ||||||
| Article Data: | 7 | ||||||
| Molecular Structure: | |||||||
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| Formula: | C7H6 Cl F3 N2 | ||||||
| Molecular Weight: | 210.586 | ||||||
| Synonyms: | 2-Aminomethyl-3-chloro-5-(trifluoromethyl)pyridine | ||||||
| Density: | 1.493g/cm3 | ||||||
| Melting Point: | 226 °C | ||||||
| Boiling Point: | 247.1°Cat760mmHg | ||||||
| Flash Point: | 103.3°C | ||||||
| Hazard Symbols: | R36/37/38:; | ||||||
| Risk Codes: | Harmful:; ">  Harmful:; |
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| Safety: |
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| PSA: | 38.91000 | ||||||
| LogP: | 2.91280 | ||||||
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Synthetic route
- 175277-74-4
(3-chloro-5-trifluoromethyl-pyridin-2-yl)methylamine
Conditions
| Conditions | Yield |
|---|---|
| With Ni-doped silica; hydrogen at 30℃; under 15001.5 Torr; Concentration; Pressure; Reagent/catalyst; | 98.57% |
| With hydrogenchloride; tin(ll) chloride In ethanol Reflux; |
- 80194-70-3
3-chloro-2-cyano-5-(trifluoromethyl)pyridine
- 175277-74-4
(3-chloro-5-trifluoromethyl-pyridin-2-yl)methylamine
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 3-chloro-2-cyano-5-(trifluoromethyl)pyridine With sodium hydroxide In methanol at 70℃; Stage #2: With sodium hypochlorite In methanol at 10℃; Solvent; Reagent/catalyst; Temperature; | 98% |
| With sulfuric acid; 20% palladium hydroxide-activated charcoal; tetrabutylammomium bromide; hydrogen In methanol at 20℃; under 15001.5 Torr; | 96.4% |
- 80194-70-3
3-chloro-2-cyano-5-(trifluoromethyl)pyridine
A
- 175277-74-4
(3-chloro-5-trifluoromethyl-pyridin-2-yl)methylamine
B
- 164341-39-3
1-[5-(trifluoromethyl)pyridin-2-yl]methanamine
Conditions
| Conditions | Yield |
|---|---|
| With hydrogen; acetic acid; nickel at 40 - 45℃; under 13501.4 Torr; for 4h; | A 97% B 0.05% |
- 175277-74-4
(3-chloro-5-trifluoromethyl-pyridin-2-yl)methylamine
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: C10H10ClF3N2O2*ClH With hydrogenchloride In water at 90 - 100℃; for 8h; Stage #2: With sodium hydroxide In water pH=9 - 9.2; Concentration; Temperature; | 90.9% |
- 175277-74-4
(3-chloro-5-trifluoromethyl-pyridin-2-yl)methylamine
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: hydrogenchloride; water / toluene / 20 °C / Inert atmosphere 2: hydrogenchloride / water / 5 h / Reflux; Inert atmosphere View Scheme |
- 175277-74-4
(3-chloro-5-trifluoromethyl-pyridin-2-yl)methylamine
Conditions
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water for 5h; Reflux; Inert atmosphere; |
- 69045-84-7
2,3-dichloro-5-trifluoromethylpyridine
- 175277-74-4
(3-chloro-5-trifluoromethyl-pyridin-2-yl)methylamine
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: tetrabutylammomium bromide; potassium carbonate / toluene; propiononitrile / 22 h / Inert atmosphere; Reflux 2: hydrogenchloride; water / toluene / 20 °C / Inert atmosphere 3: hydrogenchloride / water / 5 h / Reflux; Inert atmosphere View Scheme | |
| Multi-step reaction with 2 steps 1: potassium hydroxide / dimethyl sulfoxide / 20 °C 2: tin(ll) chloride; hydrogenchloride / ethanol / Reflux View Scheme | |
| Multi-step reaction with 3 steps 1.1: potassium carbonate; tetraethylammonium bromide / toluene / 18 h / 90 °C / Inert atmosphere 2.1: sodium tetraborate; hydrogenchloride / water / 12 h / 25 °C / Inert atmosphere 3.1: hydrogenchloride / water / 8 h / 90 - 100 °C 3.2: pH 9 - 9.2 View Scheme |
Conditions
| Conditions | Yield |
|---|---|
| With acetic anhydride at 20℃; for 16h; Concentration; | 91% |
| With acetic anhydride at 20℃; for 16h; |
- 175277-74-4
(3-chloro-5-trifluoromethyl-pyridin-2-yl)methylamine
- 55928-86-4
3,4,6-tribromopyridazine
Conditions
| Conditions | Yield |
|---|---|
| With triethylamine In methanol at 20℃; | 85% |
- 175277-74-4
(3-chloro-5-trifluoromethyl-pyridin-2-yl)methylamine
- 6082-66-2
3,4,6-trichloropyridazine
Conditions
| Conditions | Yield |
|---|---|
| With triethylamine In methanol at 20℃; | 82.2% |
