CAS No.1837-57-6,6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE Suppliers

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Basic Information

Molecular Structure:
CAS No.:	1837-57-6
Name:	6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE

Formula:	C₁₅H₁₅N₃O^.C₃H₆O₃
Molecular Weight:	343.382
Synonyms:	Lactic acid, compd. with 6, 9-diamino-2-ethoxyacridine (1:1);Flavitrol;7-ethoxyacridine-3,9-diamine; 2-hydroxypropanoic acid;3,9-Diamino-7-ethoxyacridinium lactate;Acrinol;Hectalin;Amoebin;2-Ethoxy-6,9-diaminoacridine lactate;2,5-Diamino-7-ethoxyacridine lactate;Rivanol;Propanoic acid, 2-hydroxy-, compd. with 7-ethoxy-3,9-acridinediamine (1:1);Acrolactine;Acridine, 6,9-diamino-2-ethoxy-, cpd with lactic acid (1:1);Ethodin;Rimaon;Antidian 200;6,9-Acridinediamine, 2-ethoxy-, 2-hydroxypropanoate (1:1);6, 9-Diamino-2-ethoxyacridine lactate;
EINECS:	217-408-1
Density:	1.2764 (rough estimate)
Melting Point:	62-67°C(lit.)
Boiling Point:	523.5 °C at 760 mmHg
Flash Point:	270.4 °C
Appearance:	White or almost white crystalline powder; none stink
Hazard Symbols:	Xi,Xn
Risk Codes:	R36/37/38; R22; R40; R20/21/22
PSA:	131.69000
LogP:	3.56530

Synthetic route

: 1837-57-6
ethacridine lactate

: 6,9-Diamino-5-brom-2-ethoxy-acridin

Conditions

Conditions	Yield
With N-Bromosuccinimide; acetic acid	85%

: 1837-57-6
ethacridine lactate

: 108-24-7
acetic anhydride

: N-(9-amino-2-ethoxyacridin-6-yl)acetamide

Conditions

Conditions	Yield
In acetic acid for 0.166667h;	84%

: 141-86-6
2,6-Diaminopyridine

: 1837-57-6
ethacridine lactate

: H2O4S*C20H19N7O

Conditions

Conditions	Yield
Stage #1: ethacridine lactate With sulfuric acid; sodium nitrite In water at 5℃; for 0.333333h; Stage #2: 2.6-diaminopyridine With sodium carbonate In water at 20℃; for 12h;	76.3%

: 1837-57-6
ethacridine lactate

: 90-02-8
salicylaldehyde

: 5-[(E)-(9-amino-7-ethoxyacridin-3-yl)azo]-2-hydroxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: ethacridine lactate With sulfuric acid; sodium nitrite In water at 0 - 5℃; for 0.333333h; Stage #2: salicylaldehyde With sodium carbonate In water at 20℃; for 2h;	75%

: 576-26-1
2.6-dimethylphenol

: 1837-57-6
ethacridine lactate

: 4-(9-Amino-7-ethoxy-3-acridinylazo)-2,6-dimethylphenol

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide; sodium nitrite 1) H2O, 0 deg C, 2) 5 deg C to 10 deg C; Yield given. Multistep reaction;

: 1837-57-6
ethacridine lactate

: 9-Amino-7-ethoxy-3-acridin-diazonium-ditetrafluoroborat

Conditions

Conditions	Yield
With hydrogenchloride; tetrafluoroboric acid; sodium nitrite 1) H2O, 0 deg C, 2) H2O, 0 deg C; Yield given. Multistep reaction;

: 1837-57-6
ethacridine lactate

: 74165-94-9
5-Iod-ethacridin

Conditions

Conditions	Yield
With iodine; potassium iodide

: 1837-57-6
ethacridine lactate

: 3,9-Diamino-2,4-dibrom-7-ethoxy-acridin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 85 percent / N-bromosuccinimide, aq. AcOH 2: 60 percent / N-bromosuccinimide, aq. AcOH View Scheme

: 1837-57-6
ethacridine lactate

: 55-55-0
4-(methylamino)phenol sulphate

: 2C7H7NO*C15H15N3O

Conditions

Conditions	Yield
With potassium iodate In methanol pH=3.1; aq. buffer;

: 1837-57-6
ethacridine lactate

: 6203-18-5
p-dimethylaminocinnamaldehyde

: C37H37N5O

Conditions

Conditions	Yield
With sulfuric acid In methanol

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Chemistry

Chemical Name: 6,9-Diamino-2-ethoxyacridine lactate
IUPAC NAME: 7-Ethoxyacridine-3,9-diamine ; 2-hydroxypropanoic acid
CAS No.: 1837-57-6
EINECS: 217-408-1
Molecular Formula: C₁₈H₂₁N₃O₄
Molecular Weight: 343.38 g/mol
Flash Point: 270.4 °C
Boiling Point: 523.5 °C at 760 mmHg
Polar Surface Area: 28.6 Å²
Enthalpy of Vaporization: 79.71 kJ/mol
Vapour Pressure: 4.72E-11 mmHg at 25°C
Following is the structure:

The chemical synonymous of Ethacridine lactate (CAS NO.1837-57-6) are 2-Ethoxy-6,9-diaminoacridine lactate ; Acrinol ; 6,9-Diamino-2-ethoxyacridine lactate ; Ethacridine lactate ; Ethodin ; Rivanol ; 2,5-Diamino-7-ethoxyacridinelactate ; 2-Aethoxy-6,9-diaminoacridinlactat

Uses

Ethacridine lactate (CAS NO.1837-57-6) is used as a disinfection antiseptic drug.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	70mg/kg (70mg/kg)		Pharmaceutical Chemistry Journal Vol. 26, Pg. 735, 1993.
mouse	LD50	subcutaneous	120mg/kg (120mg/kg)		British Journal of Experimental Pathology. Vol. 28, Pg. 1, 1947.
rabbit	LD50	subcutaneous	100mg/kg (100mg/kg)		Drugs in Japan Vol. -, Pg. 6, 1995.
rabbit	LDLo	intravenous	20mg/kg (20mg/kg)	VASCULAR: SHOCK	Bulletin des Sciences Pharmacologiques. Vol. 40, Pg. 582, 1933.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Poison by subcutaneous, intraperitoneal, and intravenous routes. Experimental reproductive effects. An antiseptic. When heated to decomposition it emits toxic fumes of NO_x.

Specification

Ethacridine lactate (CAS NO.1837-57-6) is an aromatic organic compound based on acridine.Its formal name is 2-ethoxy-6,9-diaminoacridine monolactate monohydrate. It forms orange-yellow crystals with a melting point of 226 °C and it has a stinging smell.Its primary use is as an antiseptic in solutions of 0.1%.It is also used as an agent for second trimester abortion. Up to 150 ml of a 0.1% solution is instilled extra-amniotically using a foley catheter. After 20 to 40 hours, 'mini labor' ensues. In China, an intra-amniotic method has also been used. Ethacridine as an abortifacient is found to be safer and better tolerated than 20% hypertonic saline.