Welcome to LookChem.com Sign In|Join Free
  • or
Home > Pharmaceutical > 18559 > 

18559-59-6

Products Categories

Basic Information
CAS No.: 18559-59-6
Name: (S)-1,2,3,4-tetrahydro-6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride
Article Data: 3
Molecular Structure:
Molecular Structure of 18559-59-6 ((S)-1,2,3,4-tetrahydro-6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride)
Formula: C19H23 N O5 . Cl H
Molecular Weight: 381.856
Synonyms: 6,7-Isoquinolinediol,1,2,3,4-tetrahydro-1-(3,4,5-trimethoxybenzyl)-, hydrochloride, (-)- (8CI);6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-[(3,4,5-trimethoxyphenyl)methyl]-,hydrochloride, (1S)- (9CI); 6,7-Isoquinolinediol,1,2,3,4-tetrahydro-1-[(3,4,5-trimethoxyphenyl)methyl]-, hydrochloride, (S)-; (-)-Trimethoquinol;(-)-Trimetoquinol; AQL 208; Bentomex; Inolin; NSC 288748; Trimethoquinol;Trimetoquinol; Trimetoquinol hydrochloride; Triquinol; Vems; l-Trimetoquinol
EINECS: 242-423-5
Density: 1.235g/cm3
Boiling Point: 533.3°Cat760mmHg
Flash Point: 276.3°C
Safety: Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl.
PSA: 80.18000
LogP: 3.68390
Related products
Synthetic route

(S)-6,7-Bis(benzyloxy)-1-<(3,4,5-trimethoxyphenyl)methyl>-1,2,3,4-tetrahydroisoquinoline hydrochloride

18559-59-6

(-)-Trimetoquinol hydrochloride

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol at 50℃; under 3040 Torr; for 16h;96%

(1S,1'S)-6,7-dibenzyloxy-2-(2-hydroxy-1-phenylethyl)-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

18559-59-6

(-)-Trimetoquinol hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; palladium on activated charcoal In ethanol86%

(3S)-8,9-dibenzyloxy-3-phenyl-2,3,5,6-tetrahydro-10bH-oxazolo-<2,3-a>isoquinoline

18559-59-6

(-)-Trimetoquinol hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: 86 percent / H2, 10percent HCl / 10percent Pd-C / ethanol
View Scheme
3840-30-0

5-(chloromethyl)-1,2,3-trimethoxybenzene

18559-59-6

(-)-Trimetoquinol hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: 86 percent / H2, 10percent HCl / 10percent Pd-C / ethanol
View Scheme

N-(2-nitrophenylsulfenyl)-β-(3-hydroxy-4-(methoxymethoxy)phenyl)ethylamine

A

18559-59-6

(-)-Trimetoquinol hydrochloride

B

(+)-Trimetoquinol hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: magnesium sulfate; (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; (S)-[1,1']-binaphthalenyl-2,2'-diol / toluene / 80 °C / Inert atmosphere
2: hydrogenchloride / ethanol; water; dichloromethane / 24 h / 20 °C
View Scheme
65299-00-5

3-hydroxy-4-(methoxymethoxy)benzaldehyde

A

18559-59-6

(-)-Trimetoquinol hydrochloride

B

(+)-Trimetoquinol hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: ammonium acetate / 1 h / Molecular sieve; Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere; Reflux
3: triethylamine; potassium carbonate / water; chloroform; methanol / 2 h / 0 °C
4: magnesium sulfate; (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; (S)-[1,1']-binaphthalenyl-2,2'-diol / toluene / 80 °C / Inert atmosphere
5: hydrogenchloride / ethanol; water; dichloromethane / 24 h / 20 °C
View Scheme
139-85-5

3,4-dihydroxybenzaldehyde

A

18559-59-6

(-)-Trimetoquinol hydrochloride

B

(+)-Trimetoquinol hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetonitrile / 0.5 h / 20 °C
1.2: 2 h
2.1: ammonium acetate / 1 h / Molecular sieve; Reflux
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere; Reflux
4.1: triethylamine; potassium carbonate / water; chloroform; methanol / 2 h / 0 °C
5.1: magnesium sulfate; (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; (S)-[1,1']-binaphthalenyl-2,2'-diol / toluene / 80 °C / Inert atmosphere
6.1: hydrogenchloride / ethanol; water; dichloromethane / 24 h / 20 °C
View Scheme

C27H30N2O8S

A

18559-59-6

(-)-Trimetoquinol hydrochloride

B

(+)-Trimetoquinol hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; dichloromethane; water at 20℃; for 24h; Overall yield = 86 %; Overall yield = 62 mg;

(E)-3-hydroxy-4-(methoxymethoxy)-1-(2-nitrovinyl)benzene

A

18559-59-6

(-)-Trimetoquinol hydrochloride

B

(+)-Trimetoquinol hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere; Reflux
2: triethylamine; potassium carbonate / water; chloroform; methanol / 2 h / 0 °C
3: magnesium sulfate; (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; (S)-[1,1']-binaphthalenyl-2,2'-diol / toluene / 80 °C / Inert atmosphere
4: hydrogenchloride / ethanol; water; dichloromethane / 24 h / 20 °C
View Scheme

β-(3-hydroxy-4-(methoxymethoxy)phenyl)ethylamine

A

18559-59-6

(-)-Trimetoquinol hydrochloride

B

(+)-Trimetoquinol hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine; potassium carbonate / water; chloroform; methanol / 2 h / 0 °C
2: magnesium sulfate; (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; (S)-[1,1']-binaphthalenyl-2,2'-diol / toluene / 80 °C / Inert atmosphere
3: hydrogenchloride / ethanol; water; dichloromethane / 24 h / 20 °C
View Scheme
Hot Products
  • Display:default sort

    New supplier

  • 6,7-Isoquinolinediol,1,2,3,4-tetrahydro-1-[(3,4,5-trimethoxyphenyl)methyl]-, hydrochloride (1:1),(1S)-

  • Casno:

    18559-59-6

    6,7-Isoquinolinediol,1,2,3,4-tetrahydro-1-[(3,4,5-trimethoxyphenyl)methyl]-, hydrochloride (1:1),(1S)-

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

    The company is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds,

  •  Henan Wentao Chemical Product Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-370-2722992

    Address:32 Room, 5th Floor, Building 11, No. 6 Yinxing Road, High-tech Industrial Development Zone, Zhengzhou City, Henan Province

       Inquiry Now

  • (S)-1,2,3,4-tetrahydro-6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride

  • Casno:

    18559-59-6

    (S)-1,2,3,4-tetrahydro-6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

    Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, r

  •  Xi`an Eastling Biotech Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-156-91766041

    Address:No. 201, Unit 4, Building 9, Hongqi Community, Tanjia Street, Weiyang District, Xi 'an, Shaanxi

       Inquiry Now

  • 6,7-Isoquinolinediol,1,2,3,4-tetrahydro-1-[(3,4,5-trimethoxyphenyl)methyl]-, hydrochloride (1:1),(1S)-

  • Casno:

    18559-59-6

    6,7-Isoquinolinediol,1,2,3,4-tetrahydro-1-[(3,4,5-trimethoxyphenyl)methyl]-, hydrochloride (1:1),(1S)-

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    1.Our services：A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

    Our company engages in Electronic chemicals such as OLED，Photoresist chemical，Electrolyte additive and Intermediate Pharmaceutical production; development of noble metal catalysts,

  •  Henan Tianfu Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-371-55170693/55170694

    Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China

       Inquiry Now

  • Trimetoquinol hydrochloride cas 18559-59-6

  • Casno:

    18559-59-6

    Trimetoquinol hydrochloride cas 18559-59-6

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Trimetoquinol hydrochloride cas 18559-59-6Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

    Welcome to Hangzhou Fandachem Co.,Ltd (www.FandaChem.com) Hangzhou Fandachem Co.,Ltd (Fandachem),an experienced and professional China-based Fine Chemical supplier. We supply the

  •  Hangzhou Fandachem Co.,Ltd

    China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+86-571-28800458

    Address:Room 5010, No.9 YanAn Road,Hangzhou,Zhejiang,China

       Inquiry Now

  • (S)-1,2,3,4-tetrahydro-6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride

  • Casno:

    18559-59-6

    (S)-1,2,3,4-tetrahydro-6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

    Henan Kanbei Chemical Co., Ltd. is a modern high-tech chemical enterprise integrating R&D, production and sales. The company has strong technical strength, advanced equipment, stri

  •  Henan Kanbei Chemical Co.,LTD

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-152-37804566

    Address:Evergrande Future City, intersection of Zhengkai Avenue and Sixteenth Street, Kaifeng Area, Henan Pilot Free Trade Zone

       Inquiry Now

  • 18559-59-6

  • Casno:

    18559-59-6

    18559-59-6

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

    Shanghai Chinqesen Biotechnology Co., Ltd. Company slogan:?Innovation, cooperation and win-win Company introduction:?Shanghai Chinqesen Biotechnology Co., Ltd. is a professional ph

  •  Shanghai Chinqesen Biotechnology Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+8617316470195

    Address:333 Songze Avenue, Qingpu District, Shanghai

       Inquiry Now

  • 6,7-Isoquinolinediol,1,2,3,4-tetrahydro-1-[(3,4,5-trimethoxyphenyl)methyl]-, hydrochloride (1:1),(1S)-

  • Casno:

    18559-59-6

    6,7-Isoquinolinediol,1,2,3,4-tetrahydro-1-[(3,4,5-trimethoxyphenyl)methyl]-, hydrochloride (1:1),(1S)-

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Joyinchem have been committed to chemical supply for several years and have built good cooperation records with multinational chemical corporations and importers from all over the world. Our services include:-Spot goods-Contract manufacturing-Custom

    Chungking Joyinchem Co.,Ltd is a specialized Chinese chemical supplier focusing on product R&D, manufacture and marketing. Our head office locates in Wulong district and the facto

  • Chungking Joyinchem Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-23-77778019

    Address:No. 55, Longhu Road, Xiangkou Town, Wulong District, Chungking City, 408500, P.R China

       Inquiry Now

  • S-(-)

  • Casno:

    18559-59-6

    S-(-)

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    FINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. FINETECH INDUSTRY LIMITED supplies the S-(-), CAS:18559-59-6 with the most competitive price and the best quality. We can of

    Finetech Industry Limited is a company in England,which specializing in developing, manufacturing and marketing fine organic compounds and intermediates for the fine chemical and p

  • Finetech Industry Limited

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-27-87465837

    Address:wuhan

       Inquiry Now

  • 18559-59-6

  • Casno:

    18559-59-6

    18559-59-6

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Supply top quality products with a reasonable price Application:api

    Hebei Ruishun Trade Co.,Ltd registered capital one million, we have a production of pharmaceutical raw materials, pharmaceutical raw materials factory reagent r&d center, we do

  • Hebei Ruishun Trade Co.,Ltd

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-311-68037669

    Address:WanDa commerce building ,yuhua district

       Inquiry Now

  • Trimetoquinol Hydrochloride

  • Casno:

    18559-59-6

    Trimetoquinol Hydrochloride

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Trimetoquinol Hydrochloride

    Since our establishment in 1951, our mission has been to assist the development of the Japanese Pharmaceutical and Health Industries. Shin Nippon Yakugyo Co., Ltd. has been contrib

  • Shin Nippon Yakugyo Co.,Ltd.

    Japan  |  Contact Details

    Business Type:Trading Company

    Tel:81-3-3667-5941

    Address:11-7, Nihonbashi-Tomizawacho Chuo-Ku, Tokyo Japan

       Inquiry Now

  • Total:19 Page 1 of 1 1
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 18559-59-6

Chemistry

Inolin is aslo named as  Tretoquinol HCL;(S)-1,2,3,4-tetrahydro-6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride;-)-Trimethoquinol;6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-[(3,4,5-trimethoxyphenyl)methyl]-, hydrochloride, (1S)- (9CI);6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-[(3,4,5-trimethoxyphenyl)methyl]-, hydrochloride, (S)-;AQL 208;Bentomex,and so on.

Molecular Formula: C19H24ClNO5
Molecular Weight: 381.85056
EINECS: 242-423-5

Toxicity Data With Reference

1.   

orl-rat TDLo:2 g/kg (7-14D preg):TER

   OYYAA2    Oyo Yakuri. Pharmacometrics. 2 (1968),383.
2.   

orl-rat LD50:2 g/kg

   YAKUD5    Gekkan Yakuji. Pharmaceuticals Monthly. 24 (1982),2331.
3.   

ipr-rat LD50:298 mg/kg

   EJPHAZ    European Journal of Pharmacology. 5 (1968),303.
4.   

scu-rat LD50:1100 mg/kg

   EJPHAZ    European Journal of Pharmacology. 5 (1968),303.
5.   

ivn-rat LD50:164 mg/kg

   EJPHAZ    European Journal of Pharmacology. 5 (1968),303.
6.   

orl-mus LD50:2250 mg/kg

   NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),529.
7.   

ipr-mus LD50:370 mg/kg

   EJPHAZ    European Journal of Pharmacology. 5 (1968),303.
8.   

scu-mus LD50:2000 mg/kg

   EJPHAZ    European Journal of Pharmacology. 5 (1968),303.
9.   

ivn-mus LD50:120 mg/kg

   NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),529.
10.   

ivn-dog LD50:160 mg/kg

   EJPHAZ    European Journ

RTECS:  NX0500000

Safety Profile

Inolin is poisonous by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl.