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Basic Information
CAS No.: 19237-84-4
Name: Prazosin hydrochloride
Article Data: 3
Molecular Structure:
Molecular Structure of 19237-84-4 (Prazosin hydrochloride)
Formula: C19H21N5O4.HCl
Molecular Weight: 419.868
Synonyms: Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-,monohydrochloride (9CI);2-[4-(2-Furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazolinehydrochloride;Adversuten;Adverszuten;Alpress LP;CP 12299-1;Deprazolin;Duramipress;Hypovase;Hypovasole;Minipress;NSC 292810;Pratsiol;Sinetens;
EINECS: 242-903-4
Melting Point: 277 - 280 °C
Boiling Point: 638.4 °C at 760 mmHg
Flash Point: 339.9 °C
Solubility: water: 1 mg/mL, clear, colorless
Appearance: off-white to yellow powder
Hazard Symbols: HarmfulXn
Risk Codes: 22-36/37/38-62
Safety: 28-36
PSA: 106.95000
LogP: 3.17070
Downstream Products
63590-64-7
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Chemistry

Product Name: Prazosin hydrochloride (CAS NO.19237-84-4)


Molecular Formula: C19H22ClN5O4
Molecular Weight: 419.86g/mol
IUPAC: [4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone hydrochloride
Mol File: 19237-84-4.mol
Einecs: 242-903-4
Appearance: Off-White to Yellow Powder
Melting Point: 277 - 280 °C
Water Solubility: 1 mg/mL, clear, colorless
Enthalpy of Vaporization: 94.28 kJ/mol
Vapour Pressure: 3.4E-16 mmHg at 25°C
Product Categories: Intermediates & Fine Chemicals ; Pharmaceuticals ; Adrenoceptor

Uses

 Prazosin hydrochloride (CAS NO.19237-84-4) is a sympatholytic drug used to treat high blood pressure (hypertension). It belongs to the class of alpha-adrenergic blockers, which lower blood pressure by relaxing blood vessels. Specifically, prazosin is selective for the alpha-1 receptors on vascular smooth muscle. These receptors are responsible for the vasoconstrictive action of norepinephrine, which would normally raise blood pressure. By blocking these receptors, prazosin reduces blood pressure. It is orally active and has a minimal effect on cardiac function due to its alpha-1 receptor selectivity. However, when prazosin is initially started, heart rate and contractility go up in order to maintain the pre-treatment blood pressures. This is because the body has reached homeostasis at this abnormally high blood pressure. The blood pressure lowering effect is apparent however when prazosin is taken for longer periods of time. The heart rate and contractility go back down over time and blood pressure decreases.
The antihypertensive characteristics of prazosin make it a second-line choice for the treatment of high blood pressure.
Prazosin is also useful in treating urinary hesitancy associated with prostatic hyperplasia by blocking alpha-1 receptors, which control constriction of both the prostate and ureters. Although not a first line choice for either hypertension or prostatic hyperplasia, it is a choice for patients who present with both problems concomitantly.
This medication has shown to be effective in treating severe nightmares in children, associated with PTSD symptoms.Also veterans have been treated successfully at the Oregon VA for sleep disturbance related to PTSD. Doses are lower for this purpose than for control of blood pressure.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 700mg/kg (700mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: NAUSEA OR VOMITING

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979.
human TDLo oral 285ug/kg (0.285mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION JAMA, Journal of the American Medical Association. Vol. 238, Pg. 157, 1977.
man TDLo oral 1714ug/kg (1.714mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Human Toxicology. Vol. 4, Pg. 53, 1985
mouse LD50 intraperitoneal 60mg/kg (60mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979.
mouse LD50 intravenous 92mg/kg (92mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
New Cardiovascular Drugs. Vol. 4, Pg. 1, 1986.
mouse LD50 oral 5gm/kg (5000mg/kg)   Medicamentos de Actualidad. Vol. 11, Pg. 64, 1975.
mouse LD50 subcutaneous 3100mg/kg (3100mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979.
rat LD50 intraperitoneal 102mg/kg (102mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979.
rat LD50 intravenous 73mg/kg (73mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
New Cardiovascular Drugs. Vol. 4, Pg. 1, 1986.
rat LD50 oral 1950mg/kg (1950mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: NAUSEA OR VOMITING

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979.
rat LD50 subcutaneous 3750mg/kg (3750mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979.
women TDLo oral 10ug/kg (0.01mg/kg) BEHAVIORAL: COMA

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER
Drug Intelligence and Clinical Pharmacy. Vol. 21, Pg. 723, 1987.
women TDLo oral 13mg/kg/6W-I (13mg/kg) BRAIN AND COVERINGS: ENCEPHALITIS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TOXIC PSYCHOSIS
British Medical Journal. Vol. 293, Pg. 1347, 1986.

Safety Profile

Safety Information of Prazosin hydrochloride (CAS NO.19237-84-4):
Hazard Codes: Xn
Risk Statements: 22-36/37/38-62 
22:  Harmful if swallowed 
36:  Irritating to the eyes 
37:  Irritating to the respiratory system 
38:  Irritating to the skin 
 Possible risk of impaired fertility
Safety Statements: 28-36
28:  After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 
36:  Wear suitable protective clothing  

Specification

 Prazosin hydrochloride ,its CAS NO. is 19237-84-4,the synonyms is 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazinehydr ; 1-(4Aamino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazinemonohydrochlo ; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-piperazinmonohydro ; 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazolinehydrochloride ; 4-Amino-6,7-dimethoxy-2-(4-(2-furoyl)piperazin-1-yl)-quinazolinhydrochlori ; CP-12299-1 ; Deprazolin ; Hypovase .