19237-84-4 Usage
Chemical Properties
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Uses
Different sources of media describe the Uses of 19237-84-4 differently. You can refer to the following data:
1. Prazosin Hydrochloride (Terazosin EP Impurity K) is an antihypertensive. α1-Adrenergic blocker.
2. Prazosin hydrochloride has been used:to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in miceas an α1-adrenoceptor blocker,administered intragastrically in ratsas a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions
3. An antihypertensive. α1-Adrenergic blocker.
Therapeutic Function
Antihypertensive
General Description
The antihypertensive effectsof prazosin hydrochloride, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine monohydrochloride(Minipress), are caused by peripheral vasodilation as a resultof its blockade of 1-adrenergic receptors. In ligand-bindingstudies, prazosin hydrochloride has 5,000-fold greater affinityfor α1-receptors than for some α2-adrenergic receptors.
Biological Activity
α 1 and α 2B -adrenoceptor antagonist. Also a potent antagonist at the melatonin MT 3 receptor (K i = 10.2 nM). Also available as part of the α 1 -Adrenoceptor Tocriset? and Mixed Adrenergic Tocriset? .
Biochem/physiol Actions
Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.
Clinical Use
Prazosin hydrochloride is readily absorbed, and plasmaconcentrations reach a peak about 3 hours after administration.Plasma half-life is between 2 and 3 hours. Prazosin hydrochlorideis highly bound to plasma protein; it does notcause adverse reactions, however, with drugs that might bedisplaced from their protein-binding sites (e.g., cardiac glycosides).It may cause severe orthostatic hypertension becauseof its -adrenergic blocking action, which preventsthe reflex venous constriction that is activated when an individualsits up from a prone position.
Purification Methods
The salt is recrystallised by dissolving it in hot MeOH, adding a small volume of MeOH/HCl (dry MeOH saturated with dry HCl gas) followed by dry Et2O until crystallisation is complete. Dry it in vacuo over solid KOH till the odour of HCl is absent. It has been recrystallised from hot H2O, the crystals are washed with H2O, and the H2O is removed azeotropically with CH2Cl2, and dried in a vacuum. [NMR and IR: Honkanen et al. J Heterocycl Chem 17 797 1980, cf Armarego & Reece Aust J Chem 34 1561 1981.] It is an antihypertensive drug and is an 1-adrenergic antagonist [Brosman et al. Proc Natl Acad Sci USA 82 5915 1985].
Check Digit Verification of cas no
The CAS Registry Mumber 19237-84-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,2,3 and 7 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 19237-84:
(7*1)+(6*9)+(5*2)+(4*3)+(3*7)+(2*8)+(1*4)=124
124 % 10 = 4
So 19237-84-4 is a valid CAS Registry Number.
InChI:InChI=1/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
19237-84-4Relevant articles and documents
New practical synthesis of prazosin
Honkanen,Pippuri,Kairisalo,et al.
, p. 797 - 798 (1980)
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Novel crystalline forms of prazosin hydrochloride
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, (2008/06/13)
The invention relates to novel and valuable crystalline forms of the hypotensive agent prazosin hydrochloride. The anhydrous α-form is preferred because it is relatively non-hygroscopic and hence possesses important advantages in handling and formulation. The polyhydrate form of prazosin hydrochloride is preferred because of its low, uniform rate of dissolution.
