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CAS No.: | 192927-63-2 |
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Name: | MOXIFLOXACIN, HYDROCHLORIDE MONOHYDRATE |
Article Data: | 2 |
Molecular Structure: | |
Formula: | C21H24FN3O4 |
Molecular Weight: | 455.914 |
Synonyms: | Actira;7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid,hydrate,hydrochloride;Moxifloxacin hydrochloride hydrate;UNII-B8956S8609; |
Density: | 1.408g/cm3 |
Melting Point: | 243-246°C dec. |
Boiling Point: | 636.4°Cat760mmHg |
Flash Point: | 338.7°C |
PSA: | 93.03000 |
LogP: | 3.50200 |
L(+)-moxifloxacin tartrate
1-cyclopropyl-7-([S,S]-2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid monohydrochloride monohydrate
Conditions | Yield |
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With hydrogenchloride; water In ethanol at 25 - 30℃; for 1h; Product distribution / selectivity; | 85% |
1-cyclopropyl-7-[(S,S)-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid fumarate
1-cyclopropyl-7-([S,S]-2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid monohydrochloride monohydrate
Conditions | Yield |
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With hydrogenchloride; water In ethanol at 25 - 30℃; for 1h; Product distribution / selectivity; | 81.82% |
1-cyclopropyl-7-[(S,S)-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid di-p-toluoyl-L-tartarate
1-cyclopropyl-7-([S,S]-2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid monohydrochloride monohydrate
Conditions | Yield |
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With hydrogenchloride; water In ethanol at 25 - 30℃; for 1h; Product distribution / selectivity; | 69.2% |
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane
1-cyclopropyl-7-([S,S]-2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid monohydrochloride monohydrate
Conditions | Yield |
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Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With boric acid; acetic anhydride; zinc(II) chloride at 25 - 120℃; for 1.5h; Stage #2: (1S,6S)-2,8-diazabicyclo[4.3.0]nonane With triethylamine In acetonitrile for 1.5h; Heating / reflux; Stage #3: With hydrogenchloride; sodium hydroxide; water; acetic acid more than 3 stages; |
1-cyclopropyl-7-([S,S]-2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid monohydrochloride monohydrate
moxifloxacin hydrochloride
Conditions | Yield |
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In toluene Heating / reflux; |