Products Categories
CAS No.: | 2106-04-9 |
---|---|
Name: | 3-Chloro-2-fluoroaniline |
Molecular Structure: | |
Formula: | C6H5ClFN |
Molecular Weight: | 145.564 |
Synonyms: | Aniline,3-chloro-2-fluoro- (6CI,8CI);(3-Chloro-2-fluorophenyl)amine;2-Fluoro-3-chloroaniline; |
EINECS: | 218-283-6 |
Density: | 1.349 g/cm3 |
Boiling Point: | 218.6 °C at 760 mmHg |
Flash Point: | 86 °C |
Appearance: | clear light beige liquid |
Hazard Symbols: | T, Xi, Xn |
Risk Codes: | 36/37/38-20/21/22-41-37/38-22-23/24/25 |
Safety: | 26-36-36/37/39-39-45 |
PSA: | 26.02000 |
LogP: | 2.64250 |
Conditions | Yield |
---|---|
With iron |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dimethylformamide; potassium fluoride / 150 °C 2: iron View Scheme |
3-chloro-2-fluoroaniline
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane for 1h; Heating / reflux; | 100% |
3-chloro-2-fluoroaniline
acetic anhydride
N-(3-chloro-2-fluorophenyl)acetamide
Conditions | Yield |
---|---|
for 2h; Reflux; | 100% |
With sodium hydroxide; acetic acid |
3-chloro-2-fluoroaniline
6-acetoxy-4-chloro-7-methoxyquinazoline
4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate
Conditions | Yield |
---|---|
In acetonitrile at 80℃; | 99% |
In isopropyl alcohol Heating; | 98% |
In isopropyl alcohol for 3h; Reflux; | 93% |
3-chloro-2-fluoroaniline
4-chloro-6-nitro-7-methoxyquinazoline
Conditions | Yield |
---|---|
In acetonitrile at 80℃; for 0.5h; | 99% |
With acetic acid; triethylamine for 48h; | 94% |
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 0 - 20℃; for 1h; | 98% |
4-chloro-7-fluoro-6-nitroquinazoline hydrochloride
3-chloro-2-fluoroaniline
N-(3-chloro-2-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine hydrochloride
Conditions | Yield |
---|---|
In isopropyl alcohol at 80℃; for 3h; | 97% |
In isopropyl alcohol Reflux; |
3-chloro-2-fluoroaniline
orthoformic acid triethyl ester
N,N'-bis(3-chloro-2-fluoro-phenyl)formamidine
Conditions | Yield |
---|---|
With acetic acid In cyclohexane at 48℃; for 6h; Inert atmosphere; Industrial scale; | 96.2% |
With acetic acid In cyclohexane at 48℃; for 12h; | 93% |
3-chloro-2-fluoroaniline
7-benzyloxy-4-chloro-6-methoxyquinazoline
7-(benzyloxy)-N-(3-chloro-2-fluorophenyl)-6-methoxyquinazolin-4-amine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane at 80℃; | 96% |
What can I do for you?
Get Best Price
The Benzenamine,3-chloro-2-fluoro-, with CAS registry number 2106-04-9, belongs to the following product categories: (1)Anilines, Aromatic Amines and Nitro Compounds; (2)Amines; (3)C2 to C6; (4)Nitrogen Compounds. It has the systematic name of 3-chloro-2-fluoroaniline. This chemical is a kind of clear light beige liquid. What's more, its EINECS is 218-283-6.
Physical properties of Benzenamine,3-chloro-2-fluoro-: (1)ACD/LogP: 2.26; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.26; (4)ACD/LogD (pH 7.4): 2.26; (5)ACD/BCF (pH 5.5): 30.71; (6)ACD/BCF (pH 7.4): 30.73; (7)ACD/KOC (pH 5.5): 403.84; (8)ACD/KOC (pH 7.4): 404.01; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 3.24 Å2; (13)Index of Refraction: 1.569; (14)Molar Refractivity: 35.37 cm3; (15)Molar Volume: 107.8 cm3; (16)Polarizability: 14.02×10-24cm3; (17)Surface Tension: 42.9 dyne/cm; (18)Enthalpy of Vaporization: 45.49 kJ/mol; (19)Vapour Pressure: 0.125 mmHg at 25°C.
Uses of p-Chloropropiophenone: it can be used to produce 2,2,2,4,4,4-hexachloro-1,3-bis-(3-chloro-2-fluoro-phenyl)-2l5,4l5-[1,3,2,4]diazadiphosphetidine. This reaction will need reagent PCl5 and solvent 1,2-dichloro-ethane. The yield is about 71%.
When you are using this chemical, please be cautious about it as the following:
The Benzenamine,3-chloro-2-fluoro- irritates to eyes, respiratory system and skin. This chemical is harmful by inhalation, in contact with skin and if swallowed and is toxic by inhalation, in contact with skin and if swallowed. This chemical has risk of serious damage to the eyes. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
You can still convert the following datas into molecular structure:
(1)SMILES: Fc1c(N)cccc1Cl
(2)InChI: InChI=1/C6H5ClFN/c7-4-2-1-3-5(9)6(4)8/h1-3H,9H2
(3)InChIKey: XWBTZHDDWRNOQH-UHFFFAOYAV
(4)Std. InChI: InChI=1S/C6H5ClFN/c7-4-2-1-3-5(9)6(4)8/h1-3H,9H2
(5)Std. InChIKey: XWBTZHDDWRNOQH-UHFFFAOYSA-N