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CAS No.: | 2341-22-2 |
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Name: | 5-Fluorocytidine |
Article Data: | 18 |
Molecular Structure: | |
Formula: | C9H12FN3O5 |
Molecular Weight: | 261.21 |
Synonyms: | 4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-pyrimidin-2-one;4-Amino-1-((2S,3S,4R,5S)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-fluoro-1-H-pyrimidin-2-one;4-amino-1-[(2S,3S,4S,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-pyrimidin-2-one;5'-Fluoro Cytidine;5-Fluoro-D-cytidine;L-5-Fluorocytidine;L-.beta.-Ribofuranosyl-5-fluoro-cytosine; |
EINECS: | 234-122-2 |
Density: | 1.98 g/cm3 |
Melting Point: | 196-200 °C(lit.) |
Boiling Point: | 511.4 °C at 760 mmHg |
Flash Point: | 263.1 °C |
Appearance: | white powder |
Hazard Symbols: | Xi,C |
Risk Codes: | 36/37/38-34 |
Safety: | 26-45-36/37/39-27 |
PSA: | 130.83000 |
LogP: | -1.84270 |
1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5-fluorocytosine
5-fluorocytidine
Conditions | Yield |
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With ammonia In methanol at 20℃; | 92% |
2',3',5'-tri-O-acetyl-4-O-methyl-5-fluorouridine
5-fluorocytidine
Conditions | Yield |
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With methanol; ammonia Ambient temperature; | 81% |
5-fluorocytidine
Conditions | Yield |
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With sodium hydrogencarbonate In N,N-dimethyl-formamide | 80.9% |
2',3',5'-tri-O-acetyl-5-fluorocytidine
5-fluorocytidine
Conditions | Yield |
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With ammonia In methanol | 55% |
5-fluorocytidine
Conditions | Yield |
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With sodium hydrogencarbonate In N,N-dimethyl-formamide | 49.2% |
1-(β-D-xylofuranosyl)-5-fluorocytosine
5-fluorocytidine
Conditions | Yield |
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Stage #1: 1-(β-D-xylofuranosyl)-5-fluorocytosine With thionyl chloride In acetonitrile at 25℃; Stage #2: With sodium hydrogencarbonate In N,N-dimethyl-formamide at 105℃; for 3h; | 49.2% |
Multi-step reaction with 2 steps 1: SOCl2 / acetonitrile 2: 49.2 percent / NaHCO3 / dimethylformamide View Scheme |
Conditions | Yield |
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Yield given. Multistep reaction. Yields of byproduct given; |
Conditions | Yield |
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With Dowex 50x2; fluorine; acetic acid Yield given. Multistep reaction; |
Conditions | Yield |
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With ammonia In methanol at 20℃; for 24h; |
1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose
5-fluorocytidine
Conditions | Yield |
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Multi-step reaction with 2 steps 1.1: hexamethyldisilazane / toluene / 3 h / Heating 1.2: 91 percent / TMS-triflate / 1,2-dichloro-ethane / 8 h / 20 °C 2.1: 92 percent / NH3 / methanol / 20 °C View Scheme |
IUPAC Name: 4-Amino-1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoropyrimidin-2-one
Synonyms of 5-Fluorocytidine (CAS NO.2341-22-2): Cytidine, 5-fluoro-
CAS NO: 2341-22-2
Classification Code: Mutation data
Molecular Formula: C9H12FN3O5
Molecular Weight: 261.2071
Molecular Structure:
Melting Point: 196-200 °C
Polar Surface Area: 128.61 Å2
Index of Refraction: 1.732
Molar Refractivity: 52.514 cm3
Molar Volume: 131.349 cm3
Surface Tension: 82.042 dyne/cm
Density of 5-Fluorocytidine (CAS NO.2341-22-2): 1.989 g/cm3
Flash Point: 263.109 °C
Enthalpy of Vaporization: 90.067 kJ/mol
Boiling Point: 511.438 °C at 760 mmHg
Hazard Codes of 5-Fluorocytidine (CAS NO.2341-22-2): Xi,C
Risk Statements: 36/37/38-34
R36/37/38: Irritating to eyes, respiratory system and skin.
R34: Causes burns.
Safety Statements: 26-45-36/37/39-27
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S27: Take off immediately all contaminated clothing.
WGK Germany: 3
RTECS: HA3890000
Hazard Note: Irritant