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| CAS No.: | 2364-75-2 |
|---|---|
| Name: | 2-Ethyl-3-hydroxy-6-methylpyridine |
| Molecular Structure: | |
|
|
|
| Formula: | C8H11NO |
| Molecular Weight: | 137.181 |
| Synonyms: | 2-Ethyl-6-methyl-3-hydroxypyridine;2-Ethyl-6-methyl-3-pyridinol;6-Methyl-2-ethyl-3-hydroxypyridine;Emoxipin;Emoxipine;Emoxypine;Epigid;Epygid;3-Pyridinol,2-ethyl-6-methyl-; |
| EINECS: | 502-841-3 |
| Density: | 1.053 g/cm3 |
| Melting Point: | 136-138 °C |
| Boiling Point: | 280.6 °C at 760 mmHg |
| Flash Point: | 123.5 °C |
| Hazard Symbols: |
 Xi
|
| PSA: | 33.12000 |
| LogP: | 1.65800 |
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5-methyl-2-propionylfuran
- 2364-75-2
emoxypine
| Conditions | Yield |
|---|---|
| With ammonia; toluene-4-sulfonic acid at 170℃; under 10501.1 Torr; for 5h; Temperature; Pressure; Autoclave; | 96.2% |
| With ethanol; ammonia at 170℃; | |
| Multi-step reaction with 3 steps 1: NH2OH*HCl, NaOH / ethanol; H2O / 0.33 h / Heating 2: Raney Ni alloy, 2 N aq. NaOH / ethanol / 1 h / Ambient temperature 3: 1.) oxygen, tetraphenylporphine, 2.) triphenylphosphine / 1.) CH2Cl2, -70 deg C, irradiation, 2 h, 2.) -70 deg C, 10 min View Scheme |
- 1344663-48-4
2-ethyl-6-methylpyridin-3-amine
- 2364-75-2
emoxypine
| Conditions | Yield |
|---|---|
| With sulfuric acid; sodium nitrite In water at 0℃; Reflux; | 90% |
- 64271-00-7
1-(5-methyl-2-furyl)propylamine
- 2364-75-2
emoxypine
| Conditions | Yield |
|---|---|
| With oxygen; 5,15,10,20-tetraphenylporphyrin; triphenylphosphine 1.) CH2Cl2, -70 deg C, irradiation, 2 h, 2.) -70 deg C, 10 min; Yield given. Multistep reaction; |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: FeCl3*6H2O / 1,2-dichloro-ethane / 1 h / Heating 2: NH2OH*HCl, NaOH / ethanol; H2O / 0.33 h / Heating 3: Raney Ni alloy, 2 N aq. NaOH / ethanol / 1 h / Ambient temperature 4: 1.) oxygen, tetraphenylporphine, 2.) triphenylphosphine / 1.) CH2Cl2, -70 deg C, irradiation, 2 h, 2.) -70 deg C, 10 min View Scheme | |
| Multi-step reaction with 2 steps 1: water containing phosphoric acid 2: ethanol; ammonia / 170 °C View Scheme |
- 133712-93-3
1-(5-methyl-[2]furyl)-propan-1-one oxime
- 2364-75-2
emoxypine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: Raney Ni alloy, 2 N aq. NaOH / ethanol / 1 h / Ambient temperature 2: 1.) oxygen, tetraphenylporphine, 2.) triphenylphosphine / 1.) CH2Cl2, -70 deg C, irradiation, 2 h, 2.) -70 deg C, 10 min View Scheme |
- 21203-68-9
2-methyl-5-nitropyridine
- 2364-75-2
emoxypine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: carbamide peroxide; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C 2.1: tetrahydrofuran / -60 °C / Inert atmosphere 2.2: -60 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / 5 h / 110 °C 4.1: sulfuric acid; sodium nitrite / water / 0 °C / Reflux View Scheme |
- 1344663-51-9
2-ethyl-6-methyl-3-nitropyridine-1-oxide
- 2364-75-2
emoxypine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: iron; acetic acid / 5 h / 110 °C 2: sulfuric acid; sodium nitrite / water / 0 °C / Reflux View Scheme |
- 36625-50-0
2-methyl-5-nitropyridine 1-oxide
- 2364-75-2
emoxypine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: tetrahydrofuran / -60 °C / Inert atmosphere 1.2: -60 - 20 °C / Inert atmosphere 2.1: iron; acetic acid / 5 h / 110 °C 3.1: sulfuric acid; sodium nitrite / water / 0 °C / Reflux View Scheme |
- 60891-70-5
1,3-diethyl 2-(5-nitropyridin-2-yl)propanedioate
- 2364-75-2
emoxypine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1.1: sulfuric acid / Heating 2.1: carbamide peroxide; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C 3.1: tetrahydrofuran / -60 °C / Inert atmosphere 3.2: -60 - 20 °C / Inert atmosphere 4.1: iron; acetic acid / 5 h / 110 °C 5.1: sulfuric acid; sodium nitrite / water / 0 °C / Reflux View Scheme |
| Conditions | Yield |
|---|---|
| With potassium carbonate In acetone for 8h; Heating; | 87% |
| With potassium carbonate 1.) acetone, reflux, 2 h, 2.) acetone, reflux, 8 h; Yield given. Multistep reaction; |
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Chemistry
Molecular Structure of 2-Ethyl-3-hydroxy-6-methylpyridine (CAS NO.2364-75-2):
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IUPAC Name: 2-Ethyl-6-methylpyridin-3-ol
Canonical SMILES: CCC1=C(C=CC(=N1)C)O
InChI: InChI=1S/C8H11NO/c1-3-7-8(10)5-4-6(2)9-7/h4-5,10H,3H2,1-2H3
InChIKey: JPGDYIGSCHWQCC-UHFFFAOYSA-N
Molecular Weight: 137.17904 [g/mol]
Molecular Formula: C8H11NO
XLogP3-AA: 1.7
H-Bond Donor: 1
H-Bond Acceptor: 2
Product Categories: pharmacetical; Pyridines
Index of Refraction: 1.536
Molar Refractivity: 40.59 cm3
Molar Volume: 130.1 cm3
Surface Tension: 41.6 dyne/cm
Density: 1.053 g/cm3
Flash Point: 123.5 °C
Enthalpy of Vaporization: 54.03 kJ/mol
Boiling Point: 280.6 °C at 760 mmHg
Vapour Pressure: 0.0022 mmHg at 25 °C
Melting Point: 136-138 °C
Classification Code: Anti-arrhythmia agents; Antioxidants; Cardiovascular Agents; Central Nervous System Agents; Drug / Therapeutic Agent; Hematologic Agents; Mutagens; Noxae; Platelet aggregation inhibitors; Protective Agents; Psychotropic drugs; Radiation-protective agents
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mammal (species unspecified) | LD50 | unreported | 620mg/kg (620mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Pharmaceutical Chemistry Journal Vol. 16, Pg. 259, 1982. |
| rat | LD50 | unreported | 900mg/kg (900mg/kg) | Toxicology and Applied Pharmacology. Vol. 85, Pg. 342, 1986. |
Safety Profile
Safety Information of 2-Ethyl-3-hydroxy-6-methylpyridine (CAS NO.2364-75-2):
Hazard Codes: 
Xi
Hazard Note: Irritant
Specification
2-Ethyl-3-hydroxy-6-methylpyridine (CAS NO.2364-75-2), its Synonyms are 2-Ethyl-6-methyl-3-hydroxypyridine ; 2-Ethyl-6-methyl-3-oxypyridine ; 2-Ethyl-6-methyl-3-pyridinol ; Emoxipin ; Emoxipine ; Emoxypine ; Epigid ; Epygid ; 6-Methyl-2-ethyl-3-hydroxypyridine ; 3-Pyridinol, 2-ethyl-6-methyl- .