Products Categories
| CAS No.: | 2375-03-3 |
|---|---|
| Name: | 6alpha-Methylprednisolone sodium succinate |
| Molecular Structure: | |
|
|
|
| Formula: | C26H33NaO8 |
| Molecular Weight: | 497.59 |
| Synonyms: | Pregna-1,4-diene-3,20-dione,11b,17,21-trihydroxy-6a-methyl-, 21-(hydrogensuccinate), monosodium salt (8CI);Succinic acid, 21-monoester with 11b,17,21-trihydroxy-6a-methylpregna-1,4-diene-3,20-dione,monosodium salt (8CI);6alpha-Methylprednisolone 21-sodiumhemisuccinate;6alpha-Methylprednisolone sodium hemisuccinate;6alpha-Methylprednisolone sodium succinate;6alpha-Methylpregnisolone 21-sodiumsuccinate;Methylprednisolone sodiumsuccinate;Metypred;NSC 48989;Sodiummethylprednisolone succinate;Solu-Medrone;Urbason Solubile;6alpha-Methylprednisolone hemisuccinate; |
| EINECS: | 219-156-8 |
| Boiling Point: | 689.6 °C at 760 mmHg |
| Flash Point: | 230.7 °C |
| Appearance: | lyophilized powder |
| Hazard Symbols: |
 T
|
| Risk Codes: | 61-40 |
| Safety: | 53-22-36/37/39-45 |
| PSA: | 141.03000 |
| LogP: | 0.88460 |
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 240444-70-62,3,5,6-Tetrafluor-4-(methoxymethyl)benzyl-2,2-dimethyl-3-(prop-1-en-1-yl)cyclopropancarboxylat
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 4704-94-32-Hydroxymethyl-1,3-propanediol
- 20846-91-7L-Aspartic acid,N,N'-1,2-ethanediylbis-
- 72963-72-5Imiprothrin
- 73978-41-36-Pteridinemethanol,2,4-diamino-, hydrochloride (1:1)
- 161718-81-61,3-Benzenedicarbonitrile,4-(2-methylpropoxy)-
- 527-31-11,2,3,4,5,6-Cyclohexanehexone
- 6864-37-5Cyclohexanamine,4,4'-methylenebis[2-methyl-
- 9036-19-5Poly(oxy-1,2-ethanediyl), α-[(1,1,3,3-tetramethylbutyl)phenyl]-ω-hydroxy-
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
What can I do for you?
Get Best Price
Specification
The 6alpha-Methylprednisolone sodium succinate with the cas number 2375-03-3, is also called sodium 4-[2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate named by IUPAC. It's system names are (1)Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-6-alpha-methyl-, 21- (hydrogen succinate), monosodium salt ; (2)Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl-, 21-(hydrogen succinate), monosodium salt (8CI) ; (3)Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, monosodium salt,(6alpha,11beta)-. It belongs to the following product categories: (1)Pharmaceutical Intermediates; (2)Aromatic Ketones (substituted); (3)ketone; (4)Materials Science so on. It is stable under ambient conditions and soluble in water, as well as ethanol and methanol, but may be light sensitive, and is incompatible with strong oxidizing agents. It is a prednisolone derivative with similar anti-inflammatory action.
Physical properties about 6alpha-Methylprednisolone sodium succinate are: (1)ACD/LogP: 2.69 ; (2)# of Rule of 5 Violations: 0 ; (3)ACD/LogD (pH 5.5): 1.46 ; (4)ACD/LogD (pH 7.4): -0.33 ; (5)ACD/BCF (pH 5.5): 3.8 ; (6)ACD/BCF (pH 7.4): 1 ; (7)ACD/KOC (pH 5.5): 40.39 ; (8)ACD/KOC (pH 7.4): 1 ; (9)#H bond acceptors: 8 ; (10)#H bond donors: 3 ; (11)#Freely Rotating Bonds: 9 ; (12)Polar Surface Area: 116.2 Å2 ; (13)Flash Point: 230.7 °C ; (14)Enthalpy of Vaporization: 115.58 kJ/mol ; (15)Boiling Point: 689.6 °C at 760 mmHg ; (16)Vapour Pressure: 5.28E-22 mmHg at 25°C
When you are using this chemical, please be cautious about it as the following: It may cause harm to the unborn child while limited evidence of a carcinogenic effect. Hence, do not breathe dust and avoid exposure - obtain special instructions before use. Before you are using this chemical, you should better wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.).
You can still convert the following datas into molecular structure :
(1).SMILES: [Na+].[O-]C(=O)CCC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@H]4[C@H]([C@@H](O)C[C@]12C)[C@]/3(/C=C\C(=O)\C=C\3[C@@H](C)C4)C
(2).InChI:InChI=1/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/q;+1/p-1/t14-,16-,17-,19-,23+,24-,25-,26-;/m0./s1
Toxic information of 6alpha-Methylprednisolone sodium succinate can be showed as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | intravenous | 571ug/kg/1M-C (0.571mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | American Journal of Emergency Medicine. Vol. 5, Pg. 42, 1987. |
| man | TDLo | intravenous | 43mg/kg/3D-I (43mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Annals of Internal Medicine. Vol. 104, Pg. 58, 1986. |
| mouse | LD50 | intraperitoneal | 880mg/kg (880mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 633, 1974. |
| mouse | LD50 | intravenous | 750mg/kg (750mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 633, 1974. |
| mouse | LD50 | oral | > 5gm/kg (5000mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 633, 1974. |
| mouse | LD50 | subcutaneous | 860mg/kg (860mg/kg) | VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 633, 1974. |
| rat | LD50 | intraperitoneal | 640mg/kg (640mg/kg) | VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 633, 1974. |
| rat | LD50 | intravenous | 640mg/kg (640mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 633, 1974. |
| rat | LD50 | oral | > 5gm/kg (5000mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 633, 1974. |
| rat | LD50 | subcutaneous | 750mg/kg (750mg/kg) | BEHAVIORAL: STIFFNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 633, 1974. |
| women | TDLo | intravenous | 60ug/kg/3D-I (0.06mg/kg) | CARDIAC: PULSE RATE | Scandinavian Journal of Rheumatology. Vol. 15, Pg. 302, 1986. |