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| CAS No.: | 2402-77-9 |
|---|---|
| Name: | 2,3-Dichloropyridine |
| Molecular Structure: | |
|
|
|
| Formula: | C5H3Cl2N |
| Molecular Weight: | 147.992 |
| Synonyms: | Pyridine, 2,3-dichloro-;2,3-Dichloro-pyridine; |
| EINECS: | 219-281-8 |
| Density: | 1.388 g/cm3 |
| Melting Point: | 64-67 °C(lit.) |
| Boiling Point: | 192.5 °C at 760 mmHg |
| Flash Point: | 87.5 °C |
| Solubility: | slightly soluble in water |
| Appearance: | White to slightly beige crystalline powder |
| Hazard Symbols: |
 Xn, Xi
|
| Risk Codes: | 36/37/38-22 |
| Safety: | 26-36-37/39 |
| PSA: | 12.89000 |
| LogP: | 2.38840 |
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- 2402-77-9
2,3-dichloro-pyridine
| Conditions | Yield |
|---|---|
| With hydrogen; triethylamine; urea; citric acid In ethyl acetate at 50℃; under 7500.75 Torr; for 7h; Solvent; Temperature; Pressure; Reagent/catalyst; Autoclave; | 98.1% |
| Conditions | Yield |
|---|---|
| With carbonylhydridetris(triphenylphosphine)rhodium(I); hydrogen; triethylamine In methanol at 60℃; under 450045 Torr; Temperature; Solvent; Pressure; Autoclave; | 98% |
| With methanol; palladium 10% on activated carbon; 3-p-menthene at 60℃; for 4h; Temperature; Reagent/catalyst; | 95% |
| With hydrogen In methanol at 75℃; under 750.075 Torr; for 8h; Reagent/catalyst; Autoclave; | 95.3% |
| Conditions | Yield |
|---|---|
| In dimethyl sulfoxide | A 96.3% B n/a |
| Conditions | Yield |
|---|---|
| Stage #1: 2-chloro-3-aminopyridine With hydrogenchloride; sodium nitrite In water at 5 - 15℃; for 0.75h; Stage #2: With hydrogenchloride; aminosulfonic acid; copper(II) chloride dihydrate In water at 55 - 62℃; Product distribution / selectivity; | 95% |
| With hydrogenchloride; thionyl chloride; nitric acid In water at 0 - 5℃; | 91% |
| With hydrogenchloride; sodium nitrite In water at -5 - 40℃; for 1h; Sandmeyer Reaction; Cooling with ice; Inert atmosphere; | 83% |
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- 2402-77-9
2,3-dichloro-pyridine
| Conditions | Yield |
|---|---|
| With phosphorus pentachloride In 1,2-dichloro-ethane at 60 - 65℃; for 10h; Reagent/catalyst; Temperature; Solvent; | 94.9% |
| With phosphorus pentachloride In 1,2-dichloro-ethane at 60 - 65℃; for 10h; Reagent/catalyst; Temperature; | 94.9% |
| With trichlorophosphate In 1,2-dichloro-ethane; N,N-dimethyl-formamide Reflux; | 43g |
| Conditions | Yield |
|---|---|
| With hydrogenchloride; copper dichloride; sodium nitrite In water at 20 - 45℃; for 5h; Reagent/catalyst; Large scale; | 89.5% |
| Conditions | Yield |
|---|---|
| With trichlorophosphate In N,N-dimethyl-formamide at 0 - 30℃; for 9h; Reagent/catalyst; | 88% |
| With chlorine In dichloromethane at 35 - 40℃; for 4h; Solvent; Temperature; | 126 g |
| With sulfolane; phosphorus pentachloride; trichlorophosphate at 150℃; for 6h; Reagent/catalyst; |
| Conditions | Yield |
|---|---|
| With pyridine; hydrogen In water at 40 - 60℃; under 2250.23 - 3750.38 Torr; Reagent/catalyst; Temperature; Pressure; Large scale; | 86.6% |
| With pyridine; hydrogen In water at 40 - 60℃; under 2250.23 - 3750.38 Torr; Temperature; Pressure; Reagent/catalyst; Large scale; | 86.6% |
| Conditions | Yield |
|---|---|
| With Dichlorophenylphosphine In various solvent(s) at 170℃; for 5h; | 81% |
| With sulfolane; phosphorus pentachloride; trichlorophosphate at 150℃; for 6h; Reagent/catalyst; |
- 2402-77-9
2,3-dichloro-pyridine
| Conditions | Yield |
|---|---|
| Stage #1: 3-chloro-2-pyridinesulfonic acid With hydrogenchloride; water In water at 103℃; for 5h; Stage #2: With sodium chlorate for 5h; Temperature; Reflux; | 80.3% |
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Chemistry
Molecular Structure of 2,3-Dichloropyridine (CAS NO.2402-77-9):
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IUPAC Name: 2,3-Dichloropyridine
Canonical SMILES: C1=CC(=C(N=C1)Cl)Cl
InChI: InChI=1S/C5H3Cl2N/c6-4-2-1-3-8-5(4)7/h1-3H
InChIKey: MAKFMOSBBNKPMS-UHFFFAOYSA-N
Molecular Weight: 147.99002 [g/mol]
Molecular Formula: C5H3Cl2N
XLogP3: 2.1
H-Bond Donor: 0
H-Bond Acceptor: 1
EINECS: 219-281-8
Index of Refraction: 1.553
Molar Refractivity: 34.13 cm3
Molar Volume: 106.5 cm3
Surface Tension: 43.1 dyne/cm
Density: 1.388 g/cm3
Flash Point: 87.5 °C
Enthalpy of Vaporization: 41.11 kJ/mol
Boiling Point: 192.5 °C at 760 mmHg
Vapour Pressure: 0.679 mmHg at 25 °C
Appearance: White to slightly beige crystalline powder
Melting Point: 64-67 °C(lit.)
Water Solubility: slightly soluble
Product Categories: blocks; Pyridines; Pyridine; Halides; Heterocycles; Pyridines, Pyrimidines, Purines and Pteredines; Pyridine series; Pyridines derivates; Chloropyridines; Halopyridines; Boronic Acid; C5Heterocyclic Building Blocks; Halogenated Heterocycles; Heterocyclic Building Blocks; Chlorinated heterocyclic series
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 135mg/kg (135mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ANTIPSYCHOTIC LIVER: FATTY LIVER DEGERATION | Toxicology and Applied Pharmacology. Vol. 11, Pg. 361, 1967. |
Safety Profile
Safety Information of 2,3-Dichloropyridine (CAS NO.2402-77-9):
Hazard Codes: 
Xi,
Xn
Risk Statements: 36/37/38-22
R36/37/38:Irritating to eyes, respiratory system and skin.
R22:Harmful if swallowed.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 3
RTECS: US8050000
Hazard Note: Irritant
HazardClass: IRRITANT
Specification
2,3-Dichloropyridine (CAS NO.2402-77-9), its Synonyms are Pyridine, 2,3-dichloro- ; 2,3-Dichlopyridine ; 2,3-Dichloro-pyridine .