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CAS No.: | 2457-47-8 |
---|---|
Name: | 3,5-Dichloropyridine |
Article Data: | 22 |
Molecular Structure: | |
Formula: | C5H3Cl2N |
Molecular Weight: | 147.992 |
Synonyms: | NSC 60546; |
EINECS: | 219-537-9 |
Density: | 1.388 g/cm3 |
Melting Point: | 65-67 °C |
Boiling Point: | 173.7 °C at 760 mmHg |
Flash Point: | 73.4 °C |
Appearance: | White to yellow powder |
Hazard Symbols: | Xn, Xi |
Risk Codes: | 22-37/38-41-36/37/38 |
Safety: | 26-39-36 |
PSA: | 12.89000 |
LogP: | 2.38840 |
3,5-dicholoropyridine N-oxide
3,5-dichloropyridine
Conditions | Yield |
---|---|
With 2,3-dimethyl-2,3-butane diol; bis(N,N-dimethylformamide)dichloridodioxidomolybdenum(VI) In N,N-dimethyl acetamide at 130℃; Microwave irradiation; Sealed tube; Green chemistry; chemoselective reaction; | 95% |
2,3,5-trichloropyridine
3,5-dichloropyridine
Conditions | Yield |
---|---|
With acetic acid; zinc In water at 65 - 95℃; for 1 - 5.25h; Product distribution / selectivity; | 87.3% |
lithioacetonitrile
3,5-dichloropyridine-4-carbonitrile
A
3,5-dichloropyridine
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 0.0833333h; | A n/a B 73% |
Conditions | Yield |
---|---|
With sodium acetate; acetic acid; zinc at 100℃; for 5.5h; Product distribution / selectivity; | 65% |
With acetic acid; zinc In water at 81 - 82℃; for 30h; Product distribution / selectivity; | 44.6 %Chromat. |
With acetic acid; zinc In 1,4-dioxane; water at 81 - 82℃; for 29h; Product distribution / selectivity; | 60.8 %Chromat. |
1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone
A
3,5-dichloropyridine
B
etoricoxib
Conditions | Yield |
---|---|
With ammonium acetate In propionic acid at 125℃; | A n/a B 62% C 15% |
methyllithium
3,5-dichloropyridine-4-carbonitrile
A
3,5-dichloro-4-picoline
B
3,5-dichloropyridine
D
methyl 3,5-dichloro-4-pyridyl imine
Conditions | Yield |
---|---|
In tetrahydrofuran at -75℃; for 0.333333h; | A 12% B 12% C 9% D 57% |
methyllithium
3,5-dichloropyridine-4-carbonitrile
A
3,5-dichloro-4-picoline
B
3,5-dichloropyridine
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 0.333333h; | A 3% B 45% C 32% |
2,3,5-trichloropyridine
A
3,5-dichloropyridine
Conditions | Yield |
---|---|
With hydrazine hydrate In dimethyl sulfoxide Heating; | A 18% B 28% |
Conditions | Yield |
---|---|
With phosphorus pentachloride |
Conditions | Yield |
---|---|
With chlorine Eintragen des Reaktionsgemisches in eine heisse wss. Loesung von Ammoniumchlorid und Eisen(III)-chlorid; | |
With chlorine Eintragen des Reaktionsgemisches in eine heisse wss. Loesung von Ammoniumchlorid und Eisen(III)-chlorid; |
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3,5-Dichloropyridine (2457-47-8) is also named as Dichloropyridine,98% ; 3,5-Dichloroypyridine ; 3,5-Dichloropyridine,97% ; Pyridine, 3,5-dichloro- ; WLN: T6NJ CG EG ; CCRIS 1719 ; D73804_ALDRICH ; NSC60546 ; EINECS 219-537-9 ,and so on.
3,5-Dichloropyridine (2457-47-8) is usually white to yellow powder.
IUPAC Name: 3,5-dichloropyridine
CAS: 2457-47-8
Molecular Formula: C5H3Cl2N
Molecular Weight: 147.99
Molecular structure:
EINECS: 219-537-9
Melting point: 65-67°C
BRN: 1973
ACD/LogD (pH 5.5): 2.43
ACD/LogD (pH 7.4): 2.43
ACD/BCF (pH 5.5): 41.03
ACD/BCF (pH 7.4): 41.03
ACD/KOC (pH 5.5): 496.91
ACD/KOC (pH 7.4): 496.92
H bond acceptors: 1
H bond donors: 0
Freely Rotating Bonds: 0
Index of Refraction: 1.553
Molar Refractivity: 34.13 cm3
Molar Volume: 106.5 cm3
Polarizability: 13.53 10-24cm3
Surface Tension: 43.1 dyne/cm
Density: 1.388 g/cm3
Flash Point: 73.4 °C
Enthalpy of Vaporization: 39.32 kJ/mol
Boiling Point: 173.7 °C at 760 mmHg
Vapour Pressure: 1.67 mmHg at 25°C
3,5-Dichloropyridine (2457-47-8) is commonly used as pharmaceutical intermediate and pesticide intermediate.
RTECS: US8575000
mouse | LD50 | intraperitoneal | 1180mg/kg (1180mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ANTIPSYCHOTIC LIVER: FATTY LIVER DEGERATION | Toxicology and Applied Pharmacology. Vol. 11, Pg. 361, 1967. |
Hazard Codes: Xn,Xi
Risk Statements: 22-37/38-41-36/37/38 (22: Harmful if swallowed 37/38: Irritating to respiratory system and skin 41: Risk of serious damage to eyes 36/37/38: Irritating to eyes, respiratory system and skin)
Safety Statements: 26-39-36 (26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 39: Wear eye/face protection 36: Wear suitable protective clothing)
Hazard Note: Irritant
Removal in wastewater treatment of 3,5-Dichloropyridine (2457-47-8) can be stated as follows:
Total removal:3.51 percent
Total biodegradation:0.10 percent
Total sludge adsorption:3.17 percent
Total to Air:0.24 percent
(using 10000 hr Bio P,A,S)