CAS No.25024-53-7,BOC-HIS(DNP)-OH Suppliers

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Basic Information

Molecular Structure:
CAS No.:	25024-53-7
Name:	BOC-HIS(DNP)-OH
Article Data:	2

Formula:	C₁₇H₁₉N₅O₈
Molecular Weight:	421.367
Synonyms:	Histidine,N-carboxy-1-(2,4-dinitrophenyl)-, N-tert-butyl ester, L- (8CI);Boc-His(Dnp)-OH;
EINECS:	246-569-0
Density:	1.49 g/cm³
Melting Point:	98-100 °C (dec.)
Boiling Point:	663.2 °C at 760 mmHg
Flash Point:	354.9 °C
Solubility:	Slightly soluble in water.
Safety:	22-24/25
PSA:	185.09000
LogP:	3.64640

Synthetic route

: 61434-84-2
(4R)-thiazolidine-4-carboxamide

: 25024-53-7
Boc-His(Dnp)-OH

: 77897-75-7
Boc-His(DNP)-Tzl-NH2

Conditions

Conditions	Yield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 25℃; for 4h;	96%

: 141076-78-0
3-hydroxy-1,2,3-benzotriazin-4(3H)-one ethylammonium salt

: 25024-53-7
Boc-His(Dnp)-OH

: 141076-75-7
Boc-His(τ-Dnp)-NH-Et

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide 1) 0 deg C, 1 h, 2) RT, 2 h;	93%

: 25024-53-7
Boc-His(Dnp)-OH

: 141076-73-5
Boc-His(τ-Dnp)-NH2

Conditions

Conditions	Yield
With 3-hydroxy-1,2,3-benzotriazin-4(3H)-one ammonium salt; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide 1) 0 deg C, 1 h, 2) RT, 2 h;	93%

: 25024-53-7
Boc-His(Dnp)-OH

: L-leucyl-O-benzyl-L-tyrosine benzyl ester hydrochloride

: 226545-68-2
Nα-tert-butoxycarbonyl-Nim-2,4-dinitrophenyl-L-histidyl-L-leucyl-O-benzyl-L-tyrosine benzyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; isopropylamine; isopropyl alcohol In N,N-dimethyl-formamide Ambient temperature;	90%

: 141076-77-9
3-hydroxy-1,2,3-benzotriazin-4(3H)-one methylammonium salt

: 25024-53-7
Boc-His(Dnp)-OH

: 141076-74-6
Boc-His(τ-Dnp)-NH-Me

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide 1) 0 deg C, 1 h, 2) RT, 2 h;	89%

: 5680-79-5
glycine ethyl ester hydrochloride

: 25024-53-7
Boc-His(Dnp)-OH

: Boc-His(DNP)-Gly-OMe

Conditions

Conditions	Yield
Stage #1: Boc-His(Dnp)-OH With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In dichloromethane for 0.5h; Cooling with ice; Stage #2: glycine ethyl ester hydrochloride With triethylamine In dichloromethane at 20℃; Cooling with ice;	85.4%

: 143122-17-2
(2S,3S)-2-Amino-1-cyclohexyl-5-(pyridin-2-ylsulfanyl)-pentan-3-ol; hydrochloride

: 25024-53-7
Boc-His(Dnp)-OH

: 139470-37-4
{(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(pyridin-2-ylsulfanyl)-butylcarbamoyl]-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 14h; Ambient temperature;	79%

: 13325-10-5
4-Aminobutanol

: 25024-53-7
Boc-His(Dnp)-OH

: 291779-95-8
4-[Nα-tert-butyloxycarbonyl-NIm(1)-(2,4-dinitrophenyl)-L-histidyl]aminobutan-1-ol

Conditions

Conditions	Yield
With 2,3,4,5,6-pentafluorophenol; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.666667h; Substitution;	78%

: 95-95-4
2,4,5-trichlorophenol

: 25024-53-7
Boc-His(Dnp)-OH

: 95485-18-0
Nα-(tert-butyloxycarbonyl)-Nim-(2,4-dinitrophenyl)-L-histidine 2,4,5-trichlorophenyl ester

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In ethyl acetate at -5℃;	77%

: 150577-70-1
(2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexane

: 25024-53-7
Boc-His(Dnp)-OH

: 129765-76-0
N-im-(2,4-dinitrophenyl)-L-histidyl>-(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexan-2-amine

Conditions

Conditions	Yield
With N-ethylmorpholine;; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In N,N-dimethyl-formamide for 24h; Ambient temperature;	65.3%

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Chemistry

IUPAC Name:(2S)-3-[1-(2,4-dinitrophenyl)imidazol-4-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
Molecular Formula:C₁₇H₁₉N₅O₈
Molecular Weight:421.36146 g/mol
Density:1.49 g/cm³
Melting Point:98-100 °C(dec.)
Boiling Point:663.2°C at 760 mmHg
Flash Point:354.9 °C
storage temp.:-20°C
EINECS:246-569-0
Synonyms of Boc-L-His(Dnp)-OH(25024-53-7):
N-ALPHA-BOC-NIM-DINITROPHENYL-L-HISTIDINE;N-ALPHA-BOC-NIM-2,4-DINITROPHENYL-L-HISTIDINE;N-ALPHA-T-BOC-N-IM-2,4-DINITROPHENYL-L-HISTIDINE;N-ALPHA-T-BOC-N-IM-DINITROPHENYL-L-HISTIDINE;TBOC-L-HISTIDINE (DNP);n-[(1,1-dimethylethoxy)carbonyl]-1-(2,4-dinitrophenyl)-l-histidin;BOC-HIS(DNP)-OH;BOC-L-DINITROPHENYL HISTIDINE;BOC-HIS(DNP)-OH
Categories of Boc-L-His(Dnp)-OH(25024-53-7):
Amino Acid Derivatives;Amino Acids;Histidine [His, H];Boc-Amino Acids and Derivative;Boc-Amino acid series

Uses

Boc-L-His(Dnp)-OH(25024-53-7) is used as a pharmaceutical intermediate.

Safety Profile

Safety Information of Boc-L-His(Dnp)-OH(25024-53-7):
Safety Statements:22-24/25
22:Do not breathe dust
24/25:Avoid contact with skin and eyes
WGK Germany:3
F:8