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CAS No.: | 2529-45-5 |
---|---|
Name: | Flugestone 17-acetate |
Molecular Structure: | |
Formula: | C23H31FO5 |
Molecular Weight: | 406.495 |
Synonyms: | Pregn-4-ene-3,20-dione,9-fluoro-11b,17-dihydroxy-, 17-acetate(7CI,8CI);Progesterone, 9-fluoro-11b,17-dihydroxy-, 17-acetate (6CI);17a-Acetoxy-9a-fluoro-11b-hydroxy-pregn-4-ene-3,20-dione;17a-Acetoxy-9a-fluoro-11b-hydroxyprogesterone;9a-Fluoro-11b-hydroxy-17a-acetoxypregn-4-ene-3,20-dione;Chronogest;Cronolone;FGA;Flugestone acetate;Fluorogestone acetate;Flurogestone acetate;Gyncro-Mate;Synchronate;Syncro-MatePregn-4-ene-3,20-dione,17-(acetyloxy)-9-fluoro-11-hydroxy-, (11b)-; |
EINECS: | 219-776-9 |
Density: | 1.244 g/cm3 |
Melting Point: | 267.5ºC |
Boiling Point: | 526.653 °C at 760 mmHg |
Flash Point: | 272.31 °C |
Appearance: | COA |
PSA: | 80.67000 |
LogP: | 3.47210 |
9-fluoro-11β,17-dihydroxy-pregn-4-ene-3,20-dione
acetyl chloride
fluorogestone acetate
Conditions | Yield |
---|---|
With triethylamine In chloroform at 10 - 65℃; Temperature; | 97.6% |
fluorogestone acetate
Conditions | Yield |
---|---|
With hydrogen fluoride In N,N-dimethyl-formamide at -7 - -5℃; for 1h; Temperature; | 90% |
17-acetoxy-9,11β-epoxy-9β-pregn-4-ene-3,20-dione
fluorogestone acetate
Conditions | Yield |
---|---|
With hydrogen fluoride |
17-acetoxy-9-bromo-11β-hydroxy-pregn-4-ene-3,20-dione
fluorogestone acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium carbonate; water containing tetrahydrofuran 2: HF View Scheme |
pregna-4,9(11)-diene-3,20-dione-17-hydroxy-21-methyl
fluorogestone acetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: toluene-4-sulfonic acid / 1.25 h / 40 - 50 °C / Inert atmosphere 2: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / acetone; water / 2.17 h / 0 - 60 °C / Inert atmosphere 3: potassium carbonate / acetone; water / 5.5 h / 0 - 3 °C / Inert atmosphere 4: hydrogen fluoride / N,N-dimethyl-formamide / 1 h / -7 - -5 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / acetone; water / 2.17 h / 0 - 60 °C / Inert atmosphere 2: potassium carbonate / acetone; water / 5.5 h / 0 - 3 °C / Inert atmosphere 3: hydrogen fluoride / N,N-dimethyl-formamide / 1 h / -7 - -5 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine; p-toluenesulfonyl chloride / dichloromethane; toluene / 40 - 45 °C 2: sodium iodide; sodium dithionite / ethanol; water / 80 - 85 °C 3: triethylamine / chloroform / 10 - 65 °C View Scheme |
Conditions | Yield |
---|---|
With pyridine; chromium(VI) oxide |
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IUPAC Name: [(8S,9R,10S,11S,13S,14S,17R)-17-Acetyl-9-fluoro-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate
Molecular Weight: 406.487643 [g/mol]
Molecular Formula: C23H31FO5
XLogP3: 2.3
H-Bond Donor: 1
H-Bond Acceptor: 6
EINECS: 219-776-9
Index of Refraction: 1.548
Molar Refractivity: 103.767 cm3
Molar Volume: 326.69 cm3
Surface Tension: 47.655 dyne/cm
Density: 1.244 g/cm3
Flash Point: 272.31 °C
Enthalpy of Vaporization: 92.16 kJ/mol
Boiling Point: 526.653 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25 °C
Melting Point: 267.5 °C
Classification Code of Flugestone 17-acetate (CAS NO.2529-45-5): Progestin; Reproductive Effect
Flugestone 17-acetate (CAS NO.2529-45-5), its Synonyms are 9-Fluoro-11beta,17-dihydroxypregn-4-ene-3,20-dione 17-acetate ; 9alpha-Fluoro-11-hydroxy,17alpha-acetoxy progesterone ; Cronolone ; FGA ; Fluorogesterone acetate ; Fluorogestone acetate ; Flurogestone acetate ; Gyncro-mate ; Synchro-mate ; Pregn-4-ene-3,20-dione, 17-(acetyloxy)-9-fluoro-11-hydroxy-, (11beta)- ; Pregn-4-ene-3,20-dione, 9-fluoro-11-beta,17-dihydroxy-, 17-acetate .