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CAS No.: | 2622-26-6 |
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Name: | PROPERICYAZINE |
Article Data: | 4 |
Molecular Structure: | |
Formula: | C21H23 N3 O S |
Molecular Weight: | 365.499 |
Synonyms: | Phenothiazine-2-carbonitrile,10-[3-(4-hydroxypiperidino)propyl]- (6CI,7CI,8CI); 10-[3-(4-Hydroxypiperidino)propyl]phenothiazine-2-carbonitrile;2-Cyano-10-[3-(4-hydroxy-1-piperidyl)propyl]phenothiazine;2-Cyano-10-[3-(4-hydroxypiperidino)propyl]phenothiazine; Aolept; Bayer 1409; FI6145; Nelactil; Nemactil; Neulactil; Neuleptil; Periciazine; Periciazinum;Pericyazine; Properciazine; Propericiazine; Propericyazine; RP 8909; SKF 20716 |
Density: | 1.32g/cm3 |
Melting Point: | 116-117° |
Boiling Point: | 593.4°Cat760mmHg |
Flash Point: | 312.7°C |
Solubility: | 38.01mg/L(37 oC) |
Hazard Symbols: | |
Risk Codes: | 22-36/37/38-20/21/22 |
Safety: | Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Used as an antipsychotic agent. When heated to decomposition it emits very toxic fumes of CN−, NOx, and SOx. See also NITRILES. |
PSA: | 75.80000 |
LogP: | 4.01068 |
4-HYDROXYPIPERIDINE
10H-phenothiazine-2-carbonitrile
1,3-chlorobromopropane
periciazine
Conditions | Yield |
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Stage #1: 10H-phenothiazine-2-carbonitrile; 1.3-chlorobromopropane With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 7h; Stage #2: 4-HYDROXYPIPERIDINE With triethylamine In N,N-dimethyl-formamide at 0 - 60℃; for 42h; | 40% |
periciazine
10-(3-(4-oxopiperidin-1-yl)propyl)-10H-phenothiazine-2-carbonitrile
Conditions | Yield |
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With dmap; 2-azatricyclo[3.3.1.13,7]dec-2-yloxidanyl; copper(l) chloride In acetonitrile at 20℃; for 1h; chemoselective reaction; | 97% |
yttrium(III) nitrate
periciazine
Conditions | Yield |
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In ethanol 15 min; pptn. washing (EtOH), drying (vac.); elem. anal.; | 74% |
Conditions | Yield |
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In water soln. refluxed for 6 h; cooling under ice-cold water for 4 d; ppt. filtered and dried in vac.; elem. anal.; | 50% |
Conditions | Yield |
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In sulfuric acid; water aq. H2SO4; stirring (soln. of Zr(NO3)4 in water), addn. (soln. of ligand in water, sulphuric acid), pptn., set aside (2 h); sepn. (filtration), washing (water, EtOH), drying (vac., over fused CaCl2); elem. anal.; |
Conditions | Yield |
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In ethanol addn. of ethanolic soln. of PPC to a constantly stirred ethanolic soln. of RhCl3*3H2O at room temp., pptn.; filtration, washing with ethanol and ether, drying in vac. over fused CaCl2, elem. anal.; |
Conditions | Yield |
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In ethanol addn. of ethanolic N-alkylphenothiazine soln. to ethanolic RuCl3*3H2O soln., stirring slowly; filtration; washing (ethanol, ether, several times); drying (anhydrous CaCl2, desiccator); elem. anal.; |
sodium tungstate (VI) dihydrate
periciazine
Conditions | Yield |
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With HCl In water a soln. of Na2WO4*2H2O in distd. H2O was added with stirring to a soln.of PPC in distd. H2O containing few drops of 2 M HCl; the suspn. was set aside for 3 h, filtered, washed (H2O, EtOH), dried in vac. over fused CaCl2; elem. anal.; |
Conditions | Yield |
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In hydrogenchloride (NH4)6Mo7O24*4H2O in 2 M HCl was added to soln. of ligand in water with vigorous stirring, suspn. set aside for 2 h; suspn. filtered, washed with water, ethanol and dried in vacuo over fused CaCl2; elem. anal.; | 67-79 |
Empirical Formula: C21H23N3OS
Molecular Weight: 365.4918 g/mol
EINECS: 220-071-3
Index of Refraction: 1.694
Density: 1.32 g/cm3
Flash Point: 312.7 °C
Storage tempreture: 2-8 °C
Enthalpy of Vaporization: 93.04 kJ/mol
Boiling Point: 593.4 °C at 760 mmHg
Vapour Pressure: 6.29E-15 mmHg at 25 °C
Structure of Propericiazine (CAS NO.2622-26-6):
IUPAC Name of Propericiazine (CAS NO.2622-26-6): 10-[3-(4-Hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | oral | 100mg/kg (100mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
mouse | LD50 | intraperitoneal | 115mg/kg (115mg/kg) | Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 157, Pg. 1242, 1963. | |
mouse | LD50 | intravenous | 27700ug/kg (27.7mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 1, Pg. 74, 1967. | |
mouse | LD50 | oral | 530mg/kg (530mg/kg) | Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 157, Pg. 1242, 1963. | |
mouse | LD50 | subcutaneous | 375mg/kg (375mg/kg) | Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 157, Pg. 1242, 1963. | |
rat | LD50 | intraperitoneal | 85mg/kg (85mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 43, 1972. | |
rat | LD50 | intravenous | 35mg/kg (35mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 43, 1972. | |
rat | LD50 | oral | 395mg/kg (395mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
rat | LD50 | subcutaneous | 1200mg/kg (1200mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 43, 1972. |
Cyanide and its compounds are on the Community Right-To-Know List.
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Used as an antipsychotic agent. When heated to decomposition it emits very toxic fumes of CN−, NOx, and SOx. See also NITRILES.
Hazard Codes of Propericiazine (CAS NO.2622-26-6): Xn
Risk Statements: 22-36/37/38-20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
Propericiazine ,its cas register number is 2622-26-6. It also can be called Neuleptil ; Aolept ; periciazine ; and 2-Cyano-10-[3-(4-hydroxypiperidino)propyl]phenothiazine .