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| CAS No.: | 26328-53-0 |
|---|---|
| Name: | Amoscanate |
| Molecular Structure: | |
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| Formula: | C13H9 N3 O2 S |
| Molecular Weight: | 271.299 |
| Synonyms: | Isothiocyanicacid, p-(p-nitroanilino)phenyl ester (8CI);Diphenylamine,4-isothiocyanato-4'-nitro- (8CI);4-(4-Nitroanilino)phenyl isothiocyanate;4-Isothiocyanato-4'-nitrodiphenylamine;4-Nitro-4'-isothiocyanatodiphenylamine;Amoscanate;C 9333Go;CGP 4540;CIBA 9333Go;Nithiocyamine;p-(p-Nitroanilino)phenyl isothiocyanate; |
| Density: | 1.3g/cm3 |
| Melting Point: | 196-198° |
| Boiling Point: | 469.7°Cat760mmHg |
| Flash Point: | 237.9°C |
| Safety: | Mutation data reported. An anthelmintic agent. |
| PSA: | 102.30000 |
| LogP: | 4.66890 |
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Chemistry
IUPAC Name: N-(4-Isothiocyanatophenyl)-4-nitroaniline
Molecular Formula: C13H9N3O2S
Molecular Weight: 271.29g/mol
Density:1.3g/cm3
Boiling Point: 469.7°C at 760mmHg
Flash Point: 237.9°C
Freely Rotating Bonds: 4
Polar Surface Area: 93.51 Å2
Index of Refraction: 1.654
Molar Refractivity: 76.45 cm3
Molar Volume: 208.3 cm3
Polarizability: 30.3 ×10-24cm3
Surface Tension: 52.3 dyne/cm
Enthalpy of Vaporization: 73.21 kJ/mol
Vapour Pressure: 5.38E-09 mmHg at 25°C
The Cas Register Number of Amoscanate is 26328-53-0 .The chemical synonyms of Amoscanate (CAS No.26328-53-0) are Amoscanate ; Nithiocyanamine .The molecular structure of Amoscanate (CAS No.26328-53-0) is
.
Uses
Amoscanate (CAS No.26328 - 53 - 0) is widely used to treat schistosomiasis and de-worming drugs in the nematode. It also can be used as pharmaceutical intermediates and spices industry.
Production
There are three kinds of synthesis methods:
(1) with right Dinitrofluorobenzene condensation with p-phenylenediamine derived from 4 - amino -4 '- nitro-diphenylamine, and then with the reaction of sulfur derived from phosgene.
(2) with 2 - chloro -5 - nitro - benzene sulfonic acid with the diamine condensation, was 4 - amino -4 '- nitrobenzene sulfonic acid, and then concentrated sulfuric acid hydrolysis, was 4 - amino -4' Nitrodiphenylamine, and then with the reaction of sulfur derived phosgene.
(3) from 4 - nitro--2 - acid -4 '- acetyl-amino-2-aniline by the concentrated sulfuric acid hydrolysis, was 4 - amino -4' - nitro-diphenylamine, and then with the reaction of sulfur derived from phosgene.
Toxicity Data With Reference
| 1. | dnr-esc 1 g/L | MUREAV Mutation Research 164 (1986),9. | ||
| 2. | bfa-mus/omi 250 mg/kg | TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. 1 (1980),129. | ||
| 3. | hma-mus/esc 250 mg/kg/3 H | MUREAV Mutation Research 164 (1986),9. |
Consensus Reports
EPA Genetic Toxicology Program.
Safety Profile
Mutation data reported. An anthelmintic agent.