26328-53-0

Basic information

• Product Name: Amoscanate
• Synonyms: 4-Nitro-4'-iso-thiocyanate diphenyl amine;4-Isothiocyanato-N-(4-nitrophenyl)benzenamine;C-9333 GO;CGP-4540;CIBA-9333 GO;Nithiocyamine
• CAS NO: 26328-53-0
• Molecular Formula: C₁₃H₉N₃O₂S
• Molecular Weight: 271.29
• Mol File: 26328-53-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 196-198°
• Boiling Point: 469.7°Cat760mmHg
• Flash Point: 237.9°C
• Appearance: /
• Density: 1.3474 (rough estimate)
• Vapor Pressure: 5.38E-09mmHg at 25°C
• Refractive Index: 1.6740 (estimate)
• PKA: -3.50±0.40(Predicted)
• CAS DataBase Reference: Amoscanate(CAS DataBase Reference)
• NIST Chemistry Reference: Amoscanate(26328-53-0)
• EPA Substance Registry System: Amoscanate(26328-53-0)

Safety Data

• Hazardous Substances Data: 26328-53-0(Hazardous Substances Data)

Usage

Safety Profile

Mutation data reported. Ananthelmintic agent.

InChI:InChI=1/C13H9N3O2S/c17-16(18)13-7-5-12(6-8-13)15-11-3-1-10(2-4-11)14-9-19/h1-8,15H

Upstream product

• 78889-14-2 (4-Isothiocyanato-phenyl)-carbamic acid 4-nitro-phenyl ester 
• 15191-25-0 4-isothiocyanatoaniline 
• 100-00-5 4-chlorobenzonitrile 
• 57399-97-0 N-(4-aminophenyl)carbamic acid ethyl ester 
• 78889-13-1 p-Isothiocyanatophenyl urethane 
• 78889-15-3 4-Isothiocyanatobenzoyl Azide 
• 60354-25-8 p-Isothiocyanatophenyl isocyanate 
• 53611-24-8 4-isothiocyanato benzoyl chloride 
• 2131-62-6 4-isothiocyanatobenzoic acid 
• 100-02-7 4-nitro-phenol 
• 4044-65-9 1 ,4-phenylenediisothiocyanate 

Downstream Products

• 36590-07-5 1-Methyl-3-[4-(4-nitro-phenylamino)-phenyl]-1-propyl-thiourea 
• 36590-01-9 1,1-Dihexyl-3-[4-(4-nitro-phenylamino)-phenyl]-thiourea 
• 36587-02-7 1,1-Diethyl-3-[4-(4-nitro-phenylamino)-phenyl]-thiourea 
• 36590-00-8 1,1-Dibutyl-3-[4-(4-nitro-phenylamino)-phenyl]-thiourea 

Relevant articles and documents

Design, synthesis and bioactivities of phenithionate analogues or derivatives for anti-schistosomiasis

A novel series of phenithionate analogues or derivatives were designed and synthesized using phenithionate as the lead compound, and their bioactivities were studied. Their structures were confirmed by 1H NMR, 13C NMR, HR-ESI-MS, and elemental analysis, respectively. The results of in vitro inhibitory activity measurement proved that compounds 5a, 5c, 5g, 5i, 5m and 5o had a better inhibitory effect on larva and imago schistosoma. Among them, the inhibitory activity of compound 5i for larva schistosoma was IC50 = 5.21 ± 0.04 μg mL-1, and for imago schistosoma it was IC50 = 6.35 ± 0.08 μg mL-1. Moreover, the experimental results of in vivo anti-schistosomiasis activity measurement showed that they had good anti-schistosomiasis activity. Therefore, these compounds had better drugability.