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CAS No.: | 27912-14-7 |
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Name: | Levobunolol hydrochloride |
Molecular Structure: | |
Formula: | C17H25NO3.HCl |
Molecular Weight: | 327.89 |
Synonyms: | (-)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydronaphthalene-1(2H)-one hydrochloride;Vistagan;(2S)-N-(tert-butyl)-2-hydroxy-3-[(5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)oxy]propan-1-aminium chloride;Betagan (TN);Prestwick_167;Levobunolol hydrochloride (JAN/USP);1(2H)-Naphthalenone,5-[(2S)-3-[(1,1- dimethylethyl)amino]-2-hydroxypropoxy]-3,4- dihydro-,hydrochloride;Levobunolol hydrochloride [USAN];(-)-3,4-Dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-1(2H)-naphthalenone hydrochloride;1(2H)-Naphthalenone, 5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-, hydrochloride, (-)-;Betagan; |
EINECS: | 248-725-3 |
Melting Point: | 209-211° |
Boiling Point: | 464.4 °C at 760 mmHg |
Flash Point: | 234.7 °C |
PSA: | 58.56000 |
LogP: | 3.52630 |
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Product Name: Levobunolol hydrochloride (CAS NO.27912-14-7)
Molecular Formula: C17H26ClNO3
Molecular Weight: 327.85g/mol
Mol File: 27912-14-7.mol
Einecs: 248-725-3
Appearance: Glaucoma drug
Boiling point: 464.4 °C at 760 mmHg
Flash Point: 234.7 °C
Enthalpy of Vaporization: 76.47 kJ/mol
Vapour Pressure: 2.01E-09 mmHg at 25°C
H-Bond Donor: 3
H-Bond Acceptor: 4
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | 100mg/kg (100mg/kg) | General Pharmacology. Vol. 17, Pg. 373, 1986. | |
hamster | LD50 | oral | 435mg/kg (435mg/kg) | General Pharmacology. Vol. 17, Pg. 373, 1986. | |
man | TDLo | ocular | 8571nL/kg/9W- (8571mL/kg) | BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" CARDIAC: PULSE RATE | American Heart Journal. Vol. 127, Pg. 689, 1994. |
mouse | LD50 | intravenous | 78mg/kg (78mg/kg) | General Pharmacology. Vol. 17, Pg. 373, 1986. | |
mouse | LD50 | oral | 1220mg/kg (1220mg/kg) | "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New York, Raven Press, 1980Vol. -, Pg. 317, 1980. | |
rat | LD50 | intravenous | 25mg/kg (25mg/kg) | General Pharmacology. Vol. 17, Pg. 373, 1986. | |
rat | LD50 | oral | 700mg/kg (700mg/kg) | General Pharmacology. Vol. 17, Pg. 373, 1986. | |
women | TDLo | ocular | 1uL/kg/12H-I (0.001mL/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION | Medical Journal of Australia. Vol. 161, Pg. 576, 1994. |
A poison by ingestion and intravenous routes. Questionable carcinogen with experimental neoplastigenic data reported. When heated to decomposition it emits toxic vapors of NOx and HCl.
Levobunolol hydrochloride ,its CAS NO. is 27912-14-7,the synonyms is (-)-3,4-Dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-1(2h)-naphthalenone ; (-)-Rochlorid;3,4-dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-1(2h)-naphthalenonhyd ; Betagan;gotensin ; l-Bunololhydrochloride ; Vistagan ; W7000a .