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300-42-5

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Basic Information
CAS No.: 300-42-5
Name: N,alpha-dimethylphenethylamine hydrochloride
Article Data: 2
Molecular Structure:
Molecular Structure of 300-42-5 (N,alpha-dimethylphenethylamine hydrochloride)
Formula: C10H15 N . Cl H
Molecular Weight: 185.697
Synonyms: Benzeneethanamine,N,a-dimethyl-, hydrochloride (9CI);Phenethylamine, N,a-dimethyl-, hydrochloride (8CI);(?à)-Methamphetamine hydrochloride;(?à)-N-Methylamphetaminehydrochloride;2-Methylamino-1-phenylpropane hydrochloride;N,a-Dimethylphenethylaminehydrochloride;NSC 169506;NSC 22367;Obesin;Obesine;dl-Desoxyephedrinehydrochloride;dl-Methamphetamine hydrochloride;
EINECS: 206-093-6
Melting Point: 172℃
Boiling Point: 212oC AT 760 MM HG
Hazard Symbols: 3
Risk Codes:  3:;
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Safety: Poison by ingestion, intravenous, intraperitoneal, subcutaneous, and intramuscular routes. Human systemic effects by ingestion: altered sleep patterns, anorexia, and change in heart rate. Experimental reproductive effects. An eye irritant. A powerful central nervous system stimulant. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also BENZEDRINE.
PSA: 12.03000
LogP: 3.02990
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Chemistry

Molecule structure of Desoxyephedrine hydrochloride (CAS NO.300-42-5):

IUPAC Name: N-Methyl-1-phenylpropan-2-amine hydrochloride 
Molecular Weight: 185.69374 g/mol
Molecular Formula: C10H16ClN 
Boiling Point: 215.5 °C at 760 mmHg
Flash Point: 86.8 °C
Enthalpy of Vaporization: 45.19 kJ/mol 
Vapour Pressure: 0.147 mmHg at 25 °C
H-Bond Donor: 2
H-Bond Acceptor: 1
Rotatable Bond Count: 3
Exact Mass: 185.097127
MonoIsotopic Mass: 185.097127
Topological Polar Surface Area: 12
Heavy Atom Count: 12 
Complexity: 95
Canonical SMILES: CC(CC1=CC=CC=C1)NC.Cl
InChI: InChI=1S/C10H15N.ClH/c1-9(11-2)8-10-6-4-3-5-7-10;/h3-7,9,11H,8H2,1-2H3;1H
InChIKey: TWXDDNPPQUTEOV-UHFFFAOYSA-N
EINECS: 206-093-6
Product Categories: Aromatics; Intermediates & Fine Chemicals; Isotope Labeled Compounds; Pharmaceuticals

Uses

 Desoxyephedrine hydrochloride is a CNS stimulant and also is anorexic. It can used in attention deficit disorder with hyperactivity.

Toxicity Data With Reference

1.    

eye-rbt 2% MLD

     ARZNAD    Arzneimittel-Forschung. Drug Research. 8 (1958),708.
2.    

orl-hmn TDLo:17 mg/kg:CNS,CVS

     KLWOAZ    Klinische Wochenscrift. 17 (1938),1580.
3.    

orl-rat LD50:29 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 24 (1974),166.
4.    

ipr-rat LD50:19 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 8 (1958),708.
5.    

scu-rat LD50:79,700 µg/kg

     JJPAAZ    Japanese Journal of Pharmacology. 35 (1984),273.
6.    

ivn-rat LD50:13 mg/kg

     HEPHD2    Handbook of Experimental Pharmacology. 55 (1980),527.
7.    

orl-mus LD50:15 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 24 (1974),166.
8.    

ipr-mus LD50:4000 µg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 11 (1961),271.
9.    

scu-mus LD50:9 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 11 (1961),271.
10.    

ivn-mus LD50:15 mg/kg

     HEPHD2    Handbook of Experimental Pharmacology. 55 (1980),527.
     

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, subcutaneous, and intramuscular routes. Human systemic effects by ingestion: altered sleep patterns, anorexia, and change in heart rate. Experimental reproductive effects. An eye irritant. A powerful central nervous system stimulant. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also BENZEDRINE.

Specification

 Desoxyephedrine hydrochloride (CAS NO.300-42-5) is also named as (+-)-Methamphetamine hydrochloride ; (+-)-N-Methylamphetamine hydrochloride ; 914F ; Amdram ; Amedrine ; Amphedroxy ; Amphedroxyn ; Bombita ; C 6379 ; Corvitin ; DEA oxo-5 ; Daropervamin ; Deoxyephedrine ; Depoxin ; Des-oxa-D ; Desamine ; Desfedran ; Desfedrin ; Desossiefedrina ; Desoxedrine ; Detrex ; Dexophrine ; Dopidrin ; Doxephin ; Metanfetamina ; N,alpha-Dimethylphenethylamine hydrochloride ; Neopharmedrine ; Noradrin ; Normadrine ; Norodrin ; Obesin ; Phedoxe ; Phedrisox ; Pisichergina ; Premodrin ; Psichergina ; Psicopan ; Psiquergina ; Psychergine ; Psykoton ; Semoxydrine ; dl-Desoxyephedrine hydrochloride ; dl-Methamphetamine hydrochloride . Desoxyephedrine hydrochloride (CAS NO.300-42-5) is odorless white crystals or fluffy crystalline powder with a bitter taste. It is water soluble. pH (aqueous solutions) is about 6. It is an acidic salt of the amine, so it behaves as a weak acid. Flash point data for Desoxyephedrine hydrochloride are not available; however, it is probably combustible.