CAS No.30034-03-8,Sodium cefamandole Suppliers

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Basic Information

Molecular Structure:
CAS No.:	30034-03-8
Name:	Sodium cefamandole
Article Data:	2

Formula:	C₁₈H₁₇N₆NaO₅S₂
Molecular Weight:	484.492
Synonyms:	5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[(hydroxyphenylacetyl)amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodium salt, [6R-[6a,7b(R)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-mandelamido-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodiumsalt, D- (8CI);Cefamandole sodium;Cefamandole sodium salt;Kefdole;Sodium7-D-mandelamido-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylate;Sodium [6R-[6a,7b(R)]]-7-[(hydroxyphenylacetyl)amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;
EINECS:	250-009-0
Melting Point:	>175 °C (dec.)
Appearance:	White solid
Hazard Symbols:	Xn
Risk Codes:	36/37/38-42/43
Safety:	26-36
PSA:	203.97000
LogP:	-1.23150

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Chemistry

Chemistry informtion about Cefamandole Sodium (CAS NO.30034-03-8) is:
IUPAC Name: Sodium (6r,7r)-7-[[(2r)-2-Hydroxy-2-Phenylacetyl]Amino]-3-[(1-Methyltetrazol-5-Yl)Sulfanylmethyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate
Synonyms: Cefamandole Sodium ; Cefamandole Sodium Salt ; Sodium [6r-[6alpha,7beta(R*)]]-7-[[(Formyloxy)Phenylacetyl]Amino]-3-[[(1-Methyl-1h-Tetrazol-5-Yl)Thio]Methyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate ; Sodium (6r-(6alpha,7beta(R*)))-7-((Hydroxyphenylacetyl)Amino)-3-(((1-Methyl-1h-Tetrazol-5-Yl)Thio)Methyl)-8-Oxo-5-Thia-1-Azabicyclo(4.2.0)Oct-2-Ene-2-Carboxylate ; Sodium Cefamandole ; 5-Thia-1-Azabicyclo(4.2.0)Oct-2-Ene-2-Carboxylicacid,7-Mandelamido-3-(((1-Met ; Monosodiumsalt,D-Hyl-1h-Tetrazol-5-Yl)Thio)Methyl)-8-Oxo ; 5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid, 7-[(Hydroxyphenylacetyl)Amino]-3-[[(1-Methyl-1h-Tetrazol-5-Yl)Thio]Methyl]-8-Oxo-, Monosodium Salt, [6r-[6α,7β(R*)]]-
MF: C₁₈H₁₇N₆NaO₅S₂
MW: 484.48
EINECS: 250-009-0
Melting Point: >175°C (dec.)
Storage temp.: Store at RT.
Following is the molecular structure of Cefamandole Sodium (CAS NO.30034-03-8) is:

Uses

Cefamandole Sodium (CAS NO.30034-03-8) can be used as broad-spectrum semi-synthetic cephalosporin antibiotic.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	4460mg/kg (4460mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984.
mouse	LD50	oral	> 19900mg/kg (19900mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984.
mouse	LD50	subcutaneous	10300mg/kg (10300mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984.
rabbit	LD	intravenous	> 2gm/kg (2000mg/kg)	behavioral: food intake (animal) kidney, ureter, and bladder: "changes in tubules (including acute renal failure, acute tubular necrosis)" kidney, ureter, and bladder: other changes in urine composition	Chemotherapy Vol. 27(Suppl,
rat	LD50	intravenous	4410mg/kg (4410mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984.
rat	LD50	oral	> 16600mg/kg (16600mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984.
rat	LD50	subcutaneous	12100mg/kg (12100mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984.

Safety Profile

Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SO_x, NO_x, and Na₂O.
Hazard Codes:
Harmful Xn
Risk Statements:
R36/37/38:Irritating to eyes, respiratory system and skin.
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 2
RTECS: XI0389000

Specification

Cefamandole Sodium (CAS NO.30034-03-8) is white solid.