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31785-60-1

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Basic Information
CAS No.: 31785-60-1
Name: 1-(naphthalen-1-yl)-2,3-dihydroquinazolin-4(1H)-one
Article Data: 12
Molecular Structure:
Molecular Structure of 31785-60-1 (1-(naphthalen-1-yl)-2,3-dihydroquinazolin-4(1H)-one)
Formula: C18H14 N2 O
Molecular Weight: 274.322
Synonyms: 4(1H)-Quinazolinone,2,3-dihydro-2-(1-naphthyl)- (8CI);2,3-Dihydro-2-(1-naphthyl)-4(1H)-quinazolinone; NSC 145669; U 29409
Density: 1.257g/cm3
Boiling Point: 563.6°Cat760mmHg
Flash Point: 294.6°C
Safety: Moderately toxic by intraperitoneal route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
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Chemistry

IUPAC Name: 1-Naphthalen-1-yl-2,3-dihydroquinazolin-4-one 
Molecular Formula: C18H14N2O
Molecular Weight: 274.34g/mol
Density: 1.257g/cm3
Boiling Point: 563.6°C at 760mmHg
Flash Point: 294.6°C
Freely Rotating Bonds: 1
Polar Surface Area: 23.55 Å2
Index of Refraction: 1.687
Molar Refractivity: 83.14 cm3
Molar Volume: 218.1 cm3
Polarizability: 32.96 ×10-24 cm3
Surface Tension: 53.8 dyne/cm
Enthalpy of Vaporization: 84.69 kJ/mol
Vapour Pressure: 1E-12 mmHg at 25°C
The Cas Register Number  of 2,3-Dihydro-2-(1-naphthyl)-4(1h)-quinazolinone is 31785-60-1.The chemical synonyms of 2,3-Dihydro-2-(1-naphthyl)-4(1h)-quinazolinone (CAS NO.31785-60-1) are 2,3-Dihydro-(1-naphthyl)-4-(1H)-quinazolinone ; 2,3-Dihydro-2-(1-naphthyl)-4(1H)-quinazolinone ;  2,3-Dihydro-2-(1-naphthalenyl)-4(1H)-quinazolinone ;  4(1H)-Quinazolinone, 2,3-dihydro-2-(1-naphthyl)- .The molecular structure of 2,3-Dihydro-2-(1-naphthyl)-4(1h)-quinazolinone (CAS NO.31785-60-1) is .

Uses

 2,3-Dihydro-2-(1-naphthyl)-4(1h)-quinazolinone (CAS NO.31785-60-1) can be used as pharmaceutical intermediate.

Toxicity Data With Reference

1.    

ipr-mus LD50:998 mg/kg

     NCISP*    National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 .

Safety Profile

Moderately toxic by intraperitoneal route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.

Specification

A series of derivatives of 2,3-Dihydro-2-(1-naphthyl)-4(1h)-quinazolinone (CAS NO.31785-60-1)  (DHQZ) with known antitumor activity was re-evaluated in the National Cancer Institute cancer cell line screen. Analysis by the COMPARE algorithm suggested that their cytotoxicity derived from interactions with tubulin. Significant inhibition of tubulin assembly and of the binding of radiolabeled colchicine to tubulin was demonstrated with several of the compounds, particularly NSC 145669, 175635, and 175636. The DHQZ derivatives are structurally analogous to a number of antimitotic agents, flavonols and derivatives of 2-styrylquinazolin-4(3H)-one and of 2-phenyl-4-quinolone. Structure-activity analogies between these agents, the combretastatins, and the colchicinoids were analyzed and summarized.