31785-60-1

Basic information

• Product Name: 1-(naphthalen-1-yl)-2,3-dihydroquinazolin-4(1H)-one
• CAS NO: 31785-60-1
• Molecular Formula: C₁₈H₁₄N₂O
• Molecular Weight: 274.3166
• Mol File: 31785-60-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 563.6°C at 760 mmHg
• Flash Point: 294.6°C
• Density: 1.257g/cm³
• Vapor Pressure: 1E-12mmHg at 25°C
• Refractive Index: 1.687
• CAS DataBase Reference: 1-(naphthalen-1-yl)-2,3-dihydroquinazolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(naphthalen-1-yl)-2,3-dihydroquinazolin-4(1H)-one(31785-60-1)
• EPA Substance Registry System: 1-(naphthalen-1-yl)-2,3-dihydroquinazolin-4(1H)-one(31785-60-1)

Safety Data

• Hazardous Substances Data: 31785-60-1(Hazardous Substances Data)

Usage

General Description

1-(naphthalen-1-yl)-2,3-dihydroquinazolin-4(1H)-one, also known as NQDQ, is a chemical compound that belongs to the class of quinazolinone derivatives. It is a heterocyclic compound that contains a naphthalene ring and a quinazolinone ring, and has been studied for its potential pharmaceutical applications. NQDQ has shown promising bioactivity in various studies, including anticancer, antifungal, and anti-inflammatory properties. Its unique structure and potential medicinal properties make it a valuable target for further research and development of new pharmaceuticals.

Upstream product

• 118-48-9 isatoic anhydride 
• 631-61-8 ammonium acetate 
• 66-77-3 1-naphthaldehyde 
• 1885-29-6 anthranilic acid nitrile 
• 28144-70-9 anthranilic acid amide 

Relevant articles and documents

Potassium tert-Butoxide Promoted Synthesis of Dihydroquinazolinones

We herein report an efficient synthetic protocol to access heterocyclic dihydroquinazolinones by a transition-metal-free process, involving the reaction of 2-aminobenzonitriles with aldehydes in the presence of KOtBu. The method is compatible with aromatic ketones providing 2,2-disubstituted dihydroquinazolinones in high yields. This reaction proceeds feasibly at room temperature and features a broad substrate scope and tolerance to a range of functional groups. The mechanism follows a radical pathway.

Green and efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones and their anthelmintic studies

A facile and highly efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones derivatives has been developed by the condensation of anthranilamide with aldehydes using sulfonic acid functionalized l-Proline?Fe3O4 nanoparticles as a catalyst. The advantages of this protocol are easy recovery and reusability of the catalyst besides simple work-up procedure and short reaction time. In addition, the anthelmintic activities of some selective compounds were investigated and it was found that 2-phenyl-2,3-dihydroquinazolin-4(1H)-one exhibited profound anthelmintic activity against two helminth models.

Recyclable [Ce(l -Pro) 2 ] 2 (Oxa) used as Heterogeneous Catalyst: One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1 H)-ones in Ethanol

[Ce(l -Pro) 2 ] 2 (Oxa) was used as a recyclable heterogeneous catalyst under mild conditions for the preparation of 2-aryl-2,3-dihydroquinazolin-4(1 H)-one derivatives. The one-pot protocol proceeds in ethanol using anthranilamide with several aldehydes at 50-55 °C. The catalyst can be recycled and reused three cycles without significant loss of catalytic activity.