Products Categories
| CAS No.: | 332012-40-5 |
|---|---|
| Name: | Telatinib |
| Molecular Structure: | |
|
|
|
| Formula: | C20H16ClN5O3 |
| Molecular Weight: | 409.832 |
| Synonyms: | Bay57-9352;Telatinib [INN];4-[[4-(4-Chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-N-methylpyridine-2-carboxamide;BAY-579352;2-Pyridinecarboxamide,4-[[[4-[(4-chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-;UNII-18P7197Q7J; |
| Density: | 1.418 g/cm3 |
| Boiling Point: | 713.595 °C at 760 mmHg |
| Flash Point: | 385.368 °C |
| PSA: | 102.17000 |
| LogP: | 4.41730 |
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- 332013-43-1
4-(hydroxymethyl)-N-methylpyridine-2-carboxamide
- 332013-40-8
4-chloroanilino-7-chlorofuro[2,3-d]pyridazine
- 332012-40-5
Telatinib
| Conditions | Yield |
|---|---|
| With potassium hydroxide; 18-crown-6 ether In toluene at 83 - 87℃; Product distribution / selectivity; | 46% |
| With potassium hydroxide; 18-crown-6 ether In toluene at 20 - 85℃; | 46% |
- 332013-43-1
4-(hydroxymethyl)-N-methylpyridine-2-carboxamide
- 332013-41-9
4-chloro-7-[N-(4-chlorophenyl)amino]-[2,3-d]furopyridazine
- 332012-40-5
Telatinib
| Conditions | Yield |
|---|---|
| With potassium hydroxide; 18-crown-6 ether In toluene at 20 - 87℃; Product distribution / selectivity; | 46% |
| Stage #1: 4-(hydroxymethyl)-N-methylpyridine-2-carboxamide; 4-chloro-7-[N-(4-chlorophenyl)amino]-[2,3-d]furopyridazine; 18-crown-6 ether In toluene at 20℃; for 0.166667h; Stage #2: With potassium hydroxide In toluene at 80℃; for 24h; Product distribution / selectivity; |
- 332013-40-8
4-chloroanilino-7-chlorofuro[2,3-d]pyridazine
- 1182334-19-5
2-methylaminocarbonyl-4-pyridylcarbinol hydrochloride
- 332012-40-5
Telatinib
| Conditions | Yield |
|---|---|
| With potassium tert-butylate In tetrahydrofuran; toluene at 95℃; for 24h; Temperature; Time; Autoclave; | 37.7% |
- 123-39-7
N-Methylformamide
A
- 332012-40-5
Telatinib
B
- 332012-41-6
4-(4-chlorophenylamino)-2-methylaminocarbonyl-7-(2-methylaminocarbonyl-4-pyridylmethoxy)-furo[2,3-d]pyridazine
| Conditions | Yield |
|---|---|
| With sulfuric acid; hydroxylamine-O-sulfonic acid; iron(II) sulfate In water at 20℃; for 1.83333h; Product distribution / selectivity; | A 15.2% B n/a |
| Stage #1: N-Methylformamide; N-(4-chlorophenyl)-7-(4-pyridinylmethoxy)-furo[2,3-d]pyridazin-4-amine With sulfuric acid; iron(II) sulfate; hydroxylamine-O-sulfonic acid In water at 20℃; for 1.83333h; Stage #2: With sodium citrate In water at 0℃; for 0.166667h; Product distribution / selectivity; | A 15.2% B n/a |
| With sulfuric acid; iron(II) sulfate; hydroxylamine-O-sulfonic acid In water at 20℃; for 1.66667h; | A 15.2% B n/a |
- 332013-42-0
ethyl 2-methylaminocarbonyl-4-picolinate
- 332012-40-5
Telatinib
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: sodium tetrahydroborate / isopropyl alcohol; methanol / 8 h / 25 °C / Large scale 1.2: 1 h / 0 °C / Large scale 2.1: potassium tert-butylate / toluene; tetrahydrofuran / 24 h / 95 °C / Autoclave View Scheme | |
| Multi-step reaction with 2 steps 1.1: sodium tetrahydroborate / ethanol / 18 h / 20 °C 1.3: pH 9 2.1: potassium hydroxide; 18-crown-6 ether / toluene / 83 - 87 °C View Scheme | |
| Multi-step reaction with 2 steps 1: sodium tetrahydroborate / ethanol / 18 h / 20 °C 2: potassium hydroxide; 18-crown-6 ether / toluene / 20 - 85 °C View Scheme |
- 13177-70-3
4,7-dichlorofuro[2,3-d]pyridazine
- 332012-40-5
Telatinib
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: ethanol / 4 h / Heating / reflux 2: potassium hydroxide; 18-crown-6 ether / toluene / 83 - 87 °C View Scheme | |
| Multi-step reaction with 2 steps 1: ethanol / 4 h / Heating / reflux 2: potassium hydroxide; 18-crown-6 ether / toluene / 20 - 85 °C View Scheme |
- 13177-70-3
4,7-dichlorofuro[2,3-d]pyridazine
A
- 332012-40-5
Telatinib
B
- 332012-41-6
4-(4-chlorophenylamino)-2-methylaminocarbonyl-7-(2-methylaminocarbonyl-4-pyridylmethoxy)-furo[2,3-d]pyridazine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: ethanol / 4 h / Heating / reflux 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 24 h / 125 °C 3.1: sulfuric acid; iron(II) sulfate; hydroxylamine-O-sulfonic acid / water / 1.83 h / 20 °C 3.2: 0.17 h / 0 °C View Scheme | |
| Multi-step reaction with 3 steps 1: ethanol / 4 h / Heating / reflux 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / 24 h / 125 °C 3: sulfuric acid; iron(II) sulfate; hydroxylamine-O-sulfonic acid / water / 1.67 h / 20 °C View Scheme |
- 1570-45-2
isonicotinic acid ethylester
- 332012-40-5
Telatinib
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: sulfuric acid; dihydrogen peroxide; iron(II) sulfate / water / 0.5 h / 6 - 22 °C 1.2: pH ~ 5 2.1: sodium tetrahydroborate / ethanol / 18 h / 20 °C 2.3: pH 9 3.1: potassium hydroxide; 18-crown-6 ether / toluene / 83 - 87 °C View Scheme | |
| Multi-step reaction with 3 steps 1: sulfuric acid; dihydrogen peroxide; iron(II) sulfate / water / 0.5 h / 6 - 22 °C 2: sodium tetrahydroborate / ethanol / 18 h / 20 °C 3: potassium hydroxide; 18-crown-6 ether / toluene / 20 - 85 °C View Scheme |
- 4282-24-0
furan-2,3-dicarboxylic acid
- 332012-40-5
Telatinib
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1.1: chloro-trimethyl-silane / 15.5 h / 20 °C 2.1: ethanol; water; hydrazine / 5.5 h / Heating / reflux 2.2: 4 h / Heating / reflux 3.1: pyridine; trichlorophosphate / 4 h / Heating / reflux 4.1: ethanol / 4 h / Heating / reflux 5.1: potassium hydroxide; 18-crown-6 ether / toluene / 83 - 87 °C View Scheme | |
| Multi-step reaction with 5 steps 1: chloro-trimethyl-silane / 15.5 h / 20 °C 2: hydrazine / ethanol / 5.5 h / Heating / reflux 3: pyridine; trichlorophosphate / 4 h / Heating / reflux 4: ethanol / 4 h / Heating / reflux 5: potassium hydroxide; 18-crown-6 ether / toluene / 20 - 85 °C View Scheme |
- 4282-24-0
furan-2,3-dicarboxylic acid
A
- 332012-40-5
Telatinib
B
- 332012-41-6
4-(4-chlorophenylamino)-2-methylaminocarbonyl-7-(2-methylaminocarbonyl-4-pyridylmethoxy)-furo[2,3-d]pyridazine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1.1: chloro-trimethyl-silane / 15.5 h / 20 °C 2.1: ethanol; water; hydrazine / 5.5 h / Heating / reflux 2.2: 4 h / Heating / reflux 3.1: pyridine; trichlorophosphate / 4 h / Heating / reflux 4.1: ethanol / 4 h / Heating / reflux 5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 24 h / 125 °C 6.1: sulfuric acid; iron(II) sulfate; hydroxylamine-O-sulfonic acid / water / 1.83 h / 20 °C 6.2: 0.17 h / 0 °C View Scheme | |
| Multi-step reaction with 6 steps 1: chloro-trimethyl-silane / 15.5 h / 20 °C 2: hydrazine / ethanol / 5.5 h / Heating / reflux 3: pyridine; trichlorophosphate / 4 h / Heating / reflux 4: ethanol / 4 h / Heating / reflux 5: 1,8-diazabicyclo[5.4.0]undec-7-ene / 24 h / 125 °C 6: sulfuric acid; iron(II) sulfate; hydroxylamine-O-sulfonic acid / water / 1.67 h / 20 °C View Scheme |
What can I do for you?
Get Best Price
Specification
The Telatinib, with the CAS registry number 332012-40-5, is also known as 2-Pyridinecarboxamide,4-[[[4-[(4-chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-. It belongs to the product category of API. This chemical's molecular formula is C20H16ClN5O3 and molecular weight is 409.83. What's more, its systematic name is 4-[[4-(4-chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-N-methylpyridine-2-carboxamide.
Physical properties of Telatinib are: (1)ACD/LogP: 3.34; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1; (4)ACD/LogD (pH 7.4): 1; (5)ACD/BCF (pH 5.5): 4; (6)ACD/BCF (pH 7.4): 4; (7)ACD/KOC (pH 5.5): 86; (8)ACD/KOC (pH 7.4): 86; (9)#H bond acceptors: 8; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 102.17 Å2; (13)Index of Refraction: 1.684; (14)Molar Refractivity: 109.727 cm3; (15)Molar Volume: 289.057 cm3; (16)Polarizability: 43.499×10-24cm3; (17)Surface Tension: 64.352 dyne/cm; (18)Density: 1.418 g/cm3; (19)Flash Point: 385.368 °C; (20)Enthalpy of Vaporization: 104.317 kJ/mol; (21)Boiling Point: 713.595 °C at 760 mmHg.
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CNC(=O)C1=NC=CC(=C1)COC2=NN=C(C3=C2OC=C3)NC4=CC=C(C=C4)Cl
(2)InChI: InChI=1S/C20H16ClN5O3/c1-22-19(27)16-10-12(6-8-23-16)11-29-20-17-15(7-9-28-17)18(25-26-20)24-14-4-2-13(21)3-5-14/h2-10H,11H2,1H3,(H,22,27)(H,24,25)
(3)InChIKey: QFCXANHHBCGMAS-UHFFFAOYSA-N