Products Categories
CAS No.: | 3430-10-2 |
---|---|
Name: | 3-Amino-2-picoline |
Article Data: | 21 |
Molecular Structure: | |
Formula: | C6H8N2 |
Molecular Weight: | 108.143 |
Synonyms: | 2-Picoline,3-amino- (7CI,8CI);(2-Methylpyridin-3-yl)amine;2-Methyl-3-aminopyridine;2-Methyl-3-pyridinamine;3-Amino-2-methylpyridine; |
EINECS: | -0 |
Density: | 1.068 g/cm3 |
Melting Point: | 114-119 °C |
Boiling Point: | 236.846 °C at 760 mmHg |
Flash Point: | 120.083 °C |
Appearance: | Off-white crystal |
Hazard Symbols: | Xi, T, Xn, C |
Risk Codes: | 22-37/38-41-36/37/38-34 |
Safety: | 26-36/39-45-36/37/39-36-27 |
Transport Information: | UN 2811 |
PSA: | 38.91000 |
LogP: | 1.55340 |
2,2-dimethyl-3-(2-methylpyrid-3-yl)-4-oxo-4H-1,3-benzoxazine
A
2-methyl-3-pyridinamine
B
salicylic acid
Conditions | Yield |
---|---|
With hydrogenchloride for 3h; Heating; | A 93% B n/a |
2-methyl-3-nitropyridine
2-methyl-3-pyridinamine
Conditions | Yield |
---|---|
With iron; acetic acid for 2h; Heating; | 90% |
With hydrogen; triethylamine; palladium 10% on activated carbon In methanol at 20℃; under 760.051 Torr; for 6h; |
3-aminopyridine-2-acetic acid
2-methyl-3-pyridinamine
Conditions | Yield |
---|---|
In ethanol for 5h; Heating; | 86% |
6-chloro-4-methyl-3-nitropyridine
2-methyl-3-pyridinamine
Conditions | Yield |
---|---|
With palladium on carbon; hydrogen | 66% |
With methanol; Lindlar's catalyst Hydrogenation; | |
With methanol; palladium on activated charcoal Hydrogenation; | |
With sulfuric acid; zinc |
2-methyl-3-pyridyl tosylate
2-methyl-3-pyridinamine
Conditions | Yield |
---|---|
Stage #1: 2-methyl-3-pyridyl tosylate With [(k2-P,N-di(1-adamantyl)-2-morpholinophenylphosphine)Pd(Ph)Cl]; sodium t-butanolate In 1,4-dioxane Inert atmosphere; Glovebox; Stage #2: With ammonia In 1,4-dioxane at 24℃; Inert atmosphere; Glovebox; | 46% |
Conditions | Yield |
---|---|
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane for 120h; Suzuki reaction; Heating; | 35% |
2-methyl-3-pyridinamine
2-(4,6-dichloropyrimidin-5-yl)acetaldehyde
N-[2-(4,6-dichloro-5-pyrimidinyl)ethyl]-2-methyl-3-pyridinamine
Conditions | Yield |
---|---|
Stage #1: 2-methyl-3-pyridinamine With trifluoroacetic acid at -15℃; for 0.5h; Stage #2: With sodium tris(acetoxy)borohydride for 0.5h; Stage #3: 2-(4,6-dichloropyrimidin-5-yl)acetaldehyde With water; sodium hydrogencarbonate more than 3 stages; | 100% |
With sodium cyanoborohydride; acetic acid In methanol at -15 - 20℃; for 19h; |
2-methyl-3-pyridinamine
Conditions | Yield |
---|---|
Stage #1: (7aSR,11aSR)-9-oxo-11a-(2,2,2-trifluoro-ethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid With N-ethyl-N,N-diisopropylamine; fluoro-N,N,N′,N′-bis(tetramethylene)formamidinium hexafluorophosphate In tetrahydrofuran for 0.333333h; Stage #2: 2-methyl-3-pyridinamine In tetrahydrofuran at 20 - 60℃; for 77h; | 100% |
2-methyl-3-pyridinamine
Conditions | Yield |
---|---|
With lithium hexamethyldisilazane In tetrahydrofuran; toluene at 0℃; for 0.25h; | 100% |
Conditions | Yield |
---|---|
With lithium hexamethyldisilazane In tetrahydrofuran; toluene at 20℃; for 0.0833333h; | 100% |
The 3-Amino-2-picoline with cas registry number of 3430-10-2 is a kind of compounds of pyridine. It is also known as 3-Amino-2-methylpyridine. Both its systematic name and IUPAC name are the same which is called 2-methylpyridin-3-amine. It also has the appearance of off-white crystal.
The physical properties about this chemical are: (1)ACD/LogP: 0.09; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 7.4): 0.062; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 4.639; (7)ACD/KOC (pH 7.4): 25.064; (8)#H bond acceptors: 2; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 1; (11)Index of Refraction: 1.574; (12)Molar Refractivity: 33.405 cm3; (13)Molar Volume: 101.213 cm3; (14)Surface Tension: 46.924 dyne/cm; (15)Density: 1.068 g/cm3; (16)Flash Point: 120.083 °C; (17)Enthalpy of Vaporization: 47.366 kJ/mol; (18)Boiling Point: 236.846 °C at 760 mmHg; (19)Vapour Pressure: 0.046 mmHg at 25°C.
When you are using this chemical, please be cautious about it as the following:
This chemical is harmful if swallowed and irritating to eyes, respiratory system and skin. It also causes burns. Therefore, it is better to wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. After using it, take off immediately all contaminated clothing.
You can still convert the following datas into molecular structure:
(1)SMILES: Cc1c(cccn1)N;
(2)InChI: InChI=1/C6H8N2/c1-5-6(7)3-2-4-8-5/h2-4H,7H2,1H3;
(3)InChIKey: ZSFPJJJRNUZCEV-UHFFFAOYAD