Products Categories
CAS No.: | 356783-16-9 |
---|---|
Name: | 3,6-Dichloropyrazine-2-carbonitrile |
Article Data: | 13 |
Molecular Structure: | |
Formula: | C5HCl2N3 |
Molecular Weight: | 173.989 |
Synonyms: | QC-100;2-Pyrazinecarbonitrile,3,6-dichloro;3,6-dichloro-2-pyrazinecarbonitrile; |
EINECS: | 202-303-5 |
Density: | 1.60±0.1 g/cm3 (20 oC 760 Torr) |
Boiling Point: | 262.0±35.0℃ (760 Torr) |
Flash Point: | 112.3±25.9℃ |
PSA: | 49.57000 |
LogP: | 1.65508 |
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
With pyridine; trichlorophosphate at 20 - 80℃; for 8h; Reagent/catalyst; | 90% |
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Stage #1: 6-bromo-3-hydroxypyrazine-2-carboxamide With trichlorophosphate In chlorobenzene at 60℃; for 0.5h; Stage #2: With N-ethyl-N,N-diisopropylamine In chlorobenzene at 90 - 100℃; for 2.66667h; Stage #3: With sodium hydrogencarbonate In water; toluene | 83% |
With N-ethyl-N,N-diisopropylamine; trichlorophosphate In water at 60 - 100℃; for 8h; Solvent; | 70% |
Stage #1: 6-bromo-3-hydroxypyrazine-2-carboxamide With trichlorophosphate at 70℃; for 0.25h; Stage #2: With N-ethyl-N,N-diisopropylamine at 20 - 100℃; for 6h; Stage #3: With water for 1h; | 70% |
Stage #1: 6-bromo-3-hydroxypyrazine-2-carboxamide With trichlorophosphate at 55℃; for 0.5h; Stage #2: With N-ethyl-N,N-diisopropylamine at 110℃; for 5h; | 43.7% |
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; trichlorophosphate at 75℃; for 1h; | 82% |
6-chloro-3-aminopyrazine-2-carbonitrile
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
With tert.-butylnitrite; titanium tetrachloride In dichloromethane at 0 - 20℃; for 3h; Sandmeyer Reaction; | 81% |
1,4-dioxopyrazinamide
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Stage #1: 1,4-dioxopyrazinamide With trichlorophosphate In chlorobenzene at 50 - 70℃; for 1.83333h; Stage #2: With pyridine In chlorobenzene at 110℃; for 8h; Temperature; Reagent/catalyst; | 52.55% |
Stage #1: 1,4-dioxopyrazinamide With trichlorophosphate at 50 - 70℃; for 1.83333h; Stage #2: With triethylamine at 96℃; for 6h; | 45.15% |
2-hydroxypyrazine-3-carboxamide
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: bromine / acetonitrile / 6 h / 0 - 40 °C 2.1: trichlorophosphate / chlorobenzene / 0.5 h / 60 °C 2.2: 2.67 h / 90 - 100 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: bromine; pyridine / N,N-dimethyl-formamide / 2 h / 80 - 85 °C / Inert atmosphere 2.1: trichlorophosphate / 0.5 h / 55 °C 2.2: 5 h / 110 °C View Scheme |
2-pyrazine carbonitrile
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: acetic acid; dihydrogen peroxide / 22 h / -5 - 95 °C 2.1: trichlorophosphate / 1.83 h / 50 - 70 °C 2.2: 6 h / 96 °C View Scheme |
3-aminopyrazinoic acid
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sulfuric acid / 20 °C / Cooling with ice 2: N-Bromosuccinimide / acetonitrile / 20 °C 3: sulfuric acid; sodium nitrite / 2 h / -5 - 20 °C 4: ammonium hydroxide / 3 h / 20 °C 5: trichlorophosphate; N-ethyl-N,N-diisopropylamine / water / 8 h / 60 - 100 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: sulfuric acid / 48 h / Cooling with ice 2.1: N-Bromosuccinimide / acetonitrile / 24 h / 20 °C / Inert atmosphere 3.1: sulfuric acid; sodium nitrite / 2 h / -5 - 25 °C 3.2: 1.5 h 4.1: ammonium hydroxide / 3 h / 20 °C 5.1: trichlorophosphate / 0.25 h / 70 °C 5.2: 6 h / 20 - 100 °C 5.3: 1 h View Scheme |
Methyl 3-amino-2-pyrazinecarboxylate
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: N-Bromosuccinimide / acetonitrile / 20 °C 2: sulfuric acid; sodium nitrite / 2 h / -5 - 20 °C 3: ammonium hydroxide / 3 h / 20 °C 4: trichlorophosphate; N-ethyl-N,N-diisopropylamine / water / 8 h / 60 - 100 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: N-Bromosuccinimide / acetonitrile / 24 h / 20 °C / Inert atmosphere 2.1: sulfuric acid; sodium nitrite / 2 h / -5 - 25 °C 2.2: 1.5 h 3.1: ammonium hydroxide / 3 h / 20 °C 4.1: trichlorophosphate / 0.25 h / 70 °C 4.2: 6 h / 20 - 100 °C 4.3: 1 h View Scheme |
methyl 3-amino-6-bromopyrazine-2-carboxylate
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sulfuric acid; sodium nitrite / 2 h / -5 - 20 °C 2: ammonium hydroxide / 3 h / 20 °C 3: trichlorophosphate; N-ethyl-N,N-diisopropylamine / water / 8 h / 60 - 100 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sulfuric acid; sodium nitrite / 2 h / -5 - 25 °C 1.2: 1.5 h 2.1: ammonium hydroxide / 3 h / 20 °C 3.1: trichlorophosphate / 0.25 h / 70 °C 3.2: 6 h / 20 - 100 °C 3.3: 1 h View Scheme |