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Basic Information
| CAS No.: | 367-23-7 |
|---|---|
| Name: | 1,2,4-Trifluorobenzene |
| Molecular Structure: | |
|
|
|
| Formula: | C6H3F3 |
| Molecular Weight: | 132.085 |
| Synonyms: | 1,3, 4-Trifluorobenzene;Benzene, 1,2,4-trifluoro-;1,3,4-Trifluorobenzene, misnomer; |
| EINECS: | 206-684-9 |
| Density: | 1.294 g/cm3 |
| Melting Point: | -35oC |
| Boiling Point: | 90.7 °C at 760 mmHg |
| Flash Point: | 4.4 °C |
| Appearance: | clear colourless liquid |
| Hazard Symbols: |
 F, Xi
|
| Risk Codes: | 11-36/37/38 |
| Safety: | 16-26-36-7-33-29-7/9 |
| Transport Information: | UN 1993 3/PG 2 |
| PSA: | 0.00000 |
| LogP: | 2.10390 |
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Synthetic route
Conditions
| Conditions | Yield |
|---|---|
| With tetrabutyl ammonium fluoride In dimethyl sulfoxide at 25℃; for 0.166667h; Inert atmosphere; Microwave irradiation; Anhydrous conditions; | 95% |
Conditions
| Conditions | Yield |
|---|---|
| With ammonia; copper In water at 260℃; for 1.25h; Temperature; Reagent/catalyst; | 94.9% |
| In quinoline |
Conditions
| Conditions | Yield |
|---|---|
| With [(bis(diisopropylphosphino)ethane)Ni(H)]2; triethylphosphine In 1,4-dioxane at 120℃; for 72h; | 94% |
| With C32H46N2Ru; sodium carbonate; isopropyl alcohol at 70℃; for 6h; Inert atmosphere; Schlenk technique; Glovebox; | 63% |
| With (1,3-dimethylimidazolin-2-ylidene)*AlH3 In 5,5-dimethyl-1,3-cyclohexadiene at 135℃; for 25h; | 19% |
- 165047-24-5
2,4,5-trifluorobenzaldehyde
- 367-23-7
1,2,4-trifluorobenzene
Conditions
| Conditions | Yield |
|---|---|
| With triethylsilane; C18H51CoP4Si In tetrahydrofuran at 50℃; for 6h; Inert atmosphere; | 94% |
- 769-40-4
2,3,5,6-tetrafluorothiophenol
A
- 651-80-9
1,2,4,5-tetrafluoro-3-(trifluoromethyl)benzene
B
- 367-23-7
1,2,4-trifluorobenzene
Conditions
| Conditions | Yield |
|---|---|
| With water; triethylphosphine In 1,4-dioxane at 120℃; for 4h; Schlenk technique; Inert atmosphere; Glovebox; | A 90% B 10% |
- 367-23-7
1,2,4-trifluorobenzene
Conditions
| Conditions | Yield |
|---|---|
| In diethyl ether at 120 - 180℃; for 6h; | 82% |
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 2,4-difluorophenylamine With sodium tetrafluoroborate; nitrosylsulfuric acid; acetic acid at -5 - 20℃; Stage #2: at 250℃; Inert atmosphere; | 80% |
| Stage #1: 2,4-difluorophenylamine With hydrogenchloride; fluoroboric acid; sodium nitrite In water at 25℃; for 0.00555556h; Balz-Schiemann Reaction; Stage #2: In 1,2-dichloro-benzene at 200℃; for 0.0166667h; Balz-Schiemann Reaction; | 72% |
Conditions
| Conditions | Yield |
|---|---|
| With potassium fluoride; C6H11BO3 In sulfolane (tetramethylene sulfone) at 245℃; for 3h; Inert atmosphere; | 78% |
- 392-56-3
Hexafluorobenzene
A
- 327-54-8
1,2,4,5-Tetrafluorobenzene
B
- 551-62-2
1,2,3,4-tetrafluorobenzene
C
- 363-72-4
Pentafluorobenzene
D
- 367-23-7
1,2,4-trifluorobenzene
Conditions
| Conditions | Yield |
|---|---|
| With (1,3-dimethylimidazolin-2-ylidene)*AlH3 In 5,5-dimethyl-1,3-cyclohexadiene at 135℃; for 25h; | A 74% B 3% C 18% D 4% |
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1,2,4-Trifluorobenzene
Chemistry
Toxicity Data With Reference
1,2,4-Trifluorobenzene(367-23-7) is highly flammable.
1,2,4-Trifluorobenzene(367-23-7) is irritating to eyes、respiratory system and skin.
Safety Profile
Keep 1,2,4-Trifluorobenzene(367-23-7) away from sources of ignition.
F, 
Xi
WGK Germany:3
RIDADR:UN 1993 3/PG 2
Hazard Note:Flammable
HazardClass:3
Specification
Stability:Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities:Strong oxidizing agents.
Decomposition:Carbon monoxide, carbon dioxide, HYDROGEN FLUORIDE.
Combustion Products：Fire may produce irritating, corrosive and/or toxic gases.
Incompatibilities:Strong oxidizing agents.
Decomposition:Carbon monoxide, carbon dioxide, HYDROGEN FLUORIDE.
Combustion Products：Fire may produce irritating, corrosive and/or toxic gases.