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CAS No.: | 40277-05-2 |
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Name: | 4-hydroxycyclophosphamide |
Article Data: | 20 |
Molecular Structure: | |
Formula: | C7H15Cl2N2O3P |
Molecular Weight: | 277.087 |
Synonyms: | 4-Hydroperoxydechlorocyclophosphamide;4-Hydroxycyclophosphamid;4-OH cyclophosphamide;4-Hydroxycyclophosphamide;2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ5-oxazaphosphinan-4-ol; |
Density: | 1.42g/cm3 |
Boiling Point: | 387.1°Cat760mmHg |
Flash Point: | 187.9°C |
PSA: | 71.61000 |
LogP: | 1.53120 |
cyclophosphamide
4-hydroxycyclophosphamide
Conditions | Yield |
---|---|
With dihydrogen peroxide; unspecific peroxygenase of Marasmius rotula In aq. acetate buffer at 25℃; for 1h; Reagent/catalyst; Enzymatic reaction; | 32% |
With dihydrogen peroxide; iron(II) sulfate | |
Multi-step reaction with 2 steps 1: (i) O3, (ii) H2O2 2: P(OEt)3 View Scheme |
4-hydroperoxycyclophosphamide
4-hydroxycyclophosphamide
Conditions | Yield |
---|---|
With triethyl phosphite |
cyclophosphamide
A
Carboxyphosphamide
B
aldophosphamide
C
4-hydroxycyclophosphamide
D
4-ketocyclophosphamide mustard
Conditions | Yield |
---|---|
pharmacokinetics, metabolism; |
4-hydroperoxycyclophosphamide
A
aldophosphamide
B
4-hydroxycyclophosphamide
Conditions | Yield |
---|---|
With triphenylphosphine In dichloromethane at 5℃; for 0.166667h; Rate constant; |
iminocyclophosphamide
4-hydroxycyclophosphamide
Conditions | Yield |
---|---|
With Tris buffer (1.0 M); dihydrogen peroxide at 30℃; Rate constant; |
4-hydroxycyclophosphamide
Conditions | Yield |
---|---|
With sodium thiosulfate In water |
cyclophosphamide
A
4-hydroxycyclophosphamide
B
4-peroxycyclophosphamide
C
4-ketocyclophosphamide mustard
Conditions | Yield |
---|---|
With dihydrogen peroxide; iron(II) sulfate In water at 0 - 10℃; Fenton Reaction; |
N-hydroxyurea
4-hydroxycyclophosphamide
Conditions | Yield |
---|---|
With trichloroacetic acid In water at 0℃; for 20h; | 63% |
N-hydroxyurea
4-hydroxycyclophosphamide
Conditions | Yield |
---|---|
With trichloric acid In N,N-dimethyl-formamide at 0℃; for 20h; | 62% |
2-methylpropan-2-thiol
4-hydroxycyclophosphamide
(4-tert-butylsulfanyl-2-oxo-2λ5-[1,3,2]oxazaphosphinan-2-yl)-bis-(2-chloro-ethyl)-amine
Conditions | Yield |
---|---|
In dichloromethane |