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Basic Information
| CAS No.: | 4214-75-9 |
|---|---|
| Name: | 2-Amino-3-nitropyridine |
| Article Data: | 36 |
| Molecular Structure: | |
|
|
|
| Formula: | C5H5N3O2 |
| Molecular Weight: | 139.114 |
| Synonyms: | 2-Pyridinamine, 3-nitro-;Pyridine, 2-amino-3-nitro-;5-nitro-1H-pyridin-6-amine;3-nitropyridin-2-amine;3-Nitro-2-aminopyridine;3-Nitropyridin-2-ylamine; |
| EINECS: | 224-144-0 |
| Density: | 1.437 g/cm3 |
| Melting Point: | 163-165 °C(lit.) |
| Boiling Point: | 299.1 °C at 760 mmHg |
| Flash Point: | 134.7 °C |
| Appearance: | yellow cryst. |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| PSA: | 84.73000 |
| LogP: | 1.67640 |
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Synthetic route
Conditions
| Conditions | Yield |
|---|---|
| With ammonium hydroxide at 90℃; for 16h; Sealed tube; | 97% |
| With zinc ammonium chloride at 220℃; for 7h; Temperature; Time; Concentration; Reagent/catalyst; Autoclave; | 77% |
| With ammonium acetate In diethylene glycol dimethyl ether for 12h; Heating; | 65% |
| With ammonia; sodium carbonate In N,N-dimethyl-formamide at 90℃; |
- 133520-08-8
N-tert-Butyl-N'-(3-nitro-pyridin-2-yl)-diazene N'-oxide
- 4214-75-9
2-amino-3-nitropyridine
Conditions
| Conditions | Yield |
|---|---|
| With ammonia In ethanol at 25℃; for 0.166667h; | 92% |
Conditions
| Conditions | Yield |
|---|---|
| With acetamidine hydrochloride; sodium hydroxide In water; dimethyl sulfoxide at 130℃; for 24h; Schlenk technique; chemoselective reaction; | 92% |
| With propionamidine hydrochloride; sodium t-butanolate In 1-methyl-pyrrolidin-2-one; water at 100℃; for 36h; | 92% |
Conditions
| Conditions | Yield |
|---|---|
| With sulfuric acid; nitric acid at 43 - 45℃; | A 80% B n/a |
| With sulfuric acid; nitric acid | |
| With sulfuric acid; nitric acid at 40 - 50℃; |
- 71090-35-2
1,1-diamino-2-nitroethene
- 13070-22-9, 34899-98-4
3-Diethylaminoacrolein
- 4214-75-9
2-amino-3-nitropyridine
Conditions
| Conditions | Yield |
|---|---|
| With acetic acid In ethanol for 4h; Heating; | 72% |
- 5470-18-8
2-Chloro-3-nitropyridine
- 77287-34-4, 77287-35-5, 60100-09-6
formamide
- 4214-75-9
2-amino-3-nitropyridine
Conditions
| Conditions | Yield |
|---|---|
| for 7h; Reflux; neat (no solvent); | 59% |
- 2530-26-9
3-nitropyridine
A
- 4214-76-0
5-nitro-pyridin-2-ylamine
B
- 4214-75-9
2-amino-3-nitropyridine
C
- 3346-63-2
2,6-diamino-3-nitro-pyridine
D
- 1681-37-4
4-amino-3-nitropyridine
Conditions
| Conditions | Yield |
|---|---|
| With potassium permanganate; ammonia at -33℃; for 5h; other substituted 3-nitropyridines, regioselectivity of amination; | A 19% B 33% C 2% D 24% |
| With potassium permanganate; ammonia at -33℃; for 5h; | A 19% B 33% C 2% D 24% |
...Expand
- 26482-54-2
2-(nitroamino)pyridine
A
- 4214-76-0
5-nitro-pyridin-2-ylamine
B
- 4214-75-9
2-amino-3-nitropyridine
Conditions
| Conditions | Yield |
|---|---|
| In methanol for 20h; Quantum yield; Irradiation; | A 1.7% B 10.4% |
| With sulfuric acid; potassium nitrate at 30℃; Rate constant; |
Conditions
| Conditions | Yield |
|---|---|
| With sulfuric acid |
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2-Amino-3-nitropyridine
Chemistry
CAS: 4214-75-9
MF: C5H5N3O2
MW: 139.11
EINECS: 224-144-0
mp： 163-165 °C(lit.)
Fp： 167 °C
BRN： 124468
CAS DataBase Reference： 4214-75-9(CAS DataBase Reference)
NIST Chemistry Reference： 4214-75-9(NIST)
The structure of 2-AMINO-3-NITROPYRIDINE is:
Toxicity Data With Reference
1、RTECS#: CAS# 4214-75-9: None listed
2、LD50/LC50: RTECS: Not available.
3、Carcinogenicity: 2-AMINO-3-NITROPYRIDINE - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
4、Other: The toxicological properties have not been fully investigated.
2、LD50/LC50: RTECS: Not available.
3、Carcinogenicity: 2-AMINO-3-NITROPYRIDINE - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
4、Other: The toxicological properties have not been fully investigated.
Consensus Reports
2-AMINO-3-NITROPYRIDINE is reported in EPA TSCA Inventory.
Safety Profile
Hazard Codes： Xi
WGK Germany： 3
F： 8-23
Hazard Note： Irritant
HS Code： 29333999
Risk Statements： Irritating to the eyes；Irritating to the respiratory system；Irritating to the skin
Safety Statements： In case of contact with eyes, rinse immediately with plenty of water and seek medical advice；Wear suitable protective clothing
WGK Germany： 3
F： 8-23
Hazard Note： Irritant
HS Code： 29333999
Risk Statements： Irritating to the eyes；Irritating to the respiratory system；Irritating to the skin
Safety Statements： In case of contact with eyes, rinse immediately with plenty of water and seek medical advice；Wear suitable protective clothing
Specification
1、First Aid Measures
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.
Skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation: Remove from exposure and move to fresh air immediately.
2、Handling and Storage
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Keep container closed when not in use.
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.
Skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation: Remove from exposure and move to fresh air immediately.
2、Handling and Storage
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Keep container closed when not in use.