CAS No.4480-83-5,Diglycolic anhydride Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	4480-83-5
Name:	Diglycolic anhydride
Article Data:	12

Formula:	C₄H₄O₄
Molecular Weight:	116.073
Synonyms:	Aceticacid, oxydi-, cyclic anhydride (8CI);Diglycolic anhydride (6CI);3-Oxaglutaricanhydride;Acetic acid, 2,2'-oxybis-, cyclic anhydride;Oxydiacetic anhydride;p-Dioxane-2,6-dione;1,4-Dioxane-2,6-dione;
EINECS:	224-761-5
Density:	1.423 g/cm³
Melting Point:	92-93 °C(lit.)
Boiling Point:	241.9 °C at 760 mmHg
Flash Point:	105.7 °C
Appearance:	COA
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36-24/25
PSA:	52.60000
LogP:	-0.91360

Synthetic route

: 110-99-6
2,2'-oxybis-acetic acid

: 4480-83-5
1,4-dioxane-2,6-dione

Conditions

Conditions	Yield
With oxalyl dichloride; N,N-dimethyl-formamide In toluene for 3h; Inert atmosphere; Reflux;	93%
With phosphoric acid; acetic anhydride at 145℃; for 2h; Temperature;	90%
With niobium(V) oxide hydrate In o-xylene at 160℃; for 72h; Inert atmosphere; Molecular sieve;	86%

: 4480-83-5
1,4-dioxane-2,6-dione

: 134179-38-7
2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethylamine

: 239081-53-9
17-azido-5-oxo-6-aza-3,9,12,15-tetraoxaheptadecanoic acid

Conditions

Conditions	Yield
In dichloromethane	100%
In dichloromethane at 25℃; for 36h;	98%
In dichloromethane at 25℃; for 26h;	98%
In dichloromethane
In dichloromethane

: benzyl 2-amino-2-deoxy-3,4,6-tri-O-benzyl-β-D-glucopyranoside hydrochloride

: 4480-83-5
1,4-dioxane-2,6-dione

: 871116-05-1
1,3,4,6-tetra-O-benzyl-2-deoxy-2-diglycolylimido-β-D-glucopyranoside

Conditions

Conditions	Yield
With pyridine; acetic anhydride; triethylamine at 20 - 80℃; for 6.5h;	100%

: 4480-83-5
1,4-dioxane-2,6-dione

: 67605-64-5
5-(4-aminophenyl)-10,15,20-triphenylporphyrin

: 2-{2-Oxo-2-[(4-(10,15,20-triphenylporphyrin-5-yl)phenyl)amino]ethoxy}acetic acid

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 24h;	100%
In N,N-dimethyl-formamide at 20℃;	98%

: 4480-83-5
1,4-dioxane-2,6-dione

: 112510-75-5
3-(<(4-methoxyphenyl)diphenylmethyl>amino)propanol

: 344436-62-0
2-[({3-[((4-methoxyphenyl)diphenylmethyl)amino]propyl}oxycarbonyl)methoxy]acetic Acid, Triethylammonium Salt

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 2h;	100%

: 4480-83-5
1,4-dioxane-2,6-dione

: 74-89-5
methylamine

: 63449-71-8
methylaminocarbonylmethoxyacetic acid

Conditions

Conditions	Yield
In tetrahydrofuran for 18h;	100%
In tetrahydrofuran at 20℃;
In tetrahydrofuran for 18h;	6.34 g

: 4480-83-5
1,4-dioxane-2,6-dione

: 646-19-5
heptane-1,7-diamine

: 1383455-59-1
{[7-(2-carboxymethoxyacetylamino)heptylaminocarbonyl]methoxy}acetic acid

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃;	100%
In tetrahydrofuran at 0 - 20℃;	96%
In tetrahydrofuran at 0 - 20℃;	96%

: 4480-83-5
1,4-dioxane-2,6-dione

: 1365037-86-0
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide

: 1443990-85-9
2-(2-(4-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamido)piperidin-1-yl)-2-oxoethoxy)acetic acid

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃;	100%

: 4480-83-5
1,4-dioxane-2,6-dione

: 51644-96-3
5-tert-butoxycarbonylamino-1-aminopentane

: 1391035-21-4
2,2-dimethyl-4,12-dioxo-3,14-dioxa-5,11-diazahexadecan-16-oic acid

Conditions

Conditions	Yield
In tetrahydrofuran at -50 - 20℃; for 21h;	100%

: 4480-83-5
1,4-dioxane-2,6-dione

: di-tert-butyl 2-(4-hydroxymethylphenyl)malonate

: di-tert-butyl 2-(4-methylphenyl(diglycolic acid))malonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 15h; Inert atmosphere;	100%

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Specification

The CAS registry number of Diglycolic anhydride is 4480-83-5. Its EINECS registry number is 224-761-5. The IUPAC name is 1,4-dioxane-2,6-dione. In addition, the molecular formula is C₄H₄O₄ and the molecular weight is 116.07. It is also called 3-Oxaglutaricanhydride. What's more, it belongs to the classes of Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts; Dioxanes; Dioxanes Dioxolanes and should be stored in a cool and dry place.

The properties of the chemical are: (1)ACD/LogP: -2.06; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.06; (4)ACD/LogD (pH 7.4): -2.06; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1.81; (8)ACD/KOC (pH 7.4): 1.81; (9)#H bond acceptors: 4; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 52.6 Å²; (13)Index of Refraction: 1.45; (14)Molar Refractivity: 21.91 cm³; (15)Molar Volume: 81.5 cm³; (16)Polarizability: 8.68×10^-24cm³; (17)Surface Tension: 45.3 dyne/cm; (18)Enthalpy of Vaporization: 47.88 kJ/mol; (19)Vapour Pressure: 0.0351 mmHg at 25°C.

Uses of Diglycolic anhydride: it can react with diethylamine to prepare N,N-Diethyldiglycollamsaeure. This reaction needs solvent CH₂Cl₂. The reaction time is 2 hours by heating. The yield is 81%.

Diglycolic anhydride can react with diethylamine to prepare N,N-Diethyldiglycollamsaeure

When you are using this chemical, please be cautious about it as the following:
This chemical is not only irritating to skin, but also irritating to eyes and respiratory system. During using it, you should wear suitable protective clothing and should avoid this chemical contact with skin and eyes. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C1OC(=O)COC1
(2)InChI: InChI=1/C4H4O4/c5-3-1-7-2-4(6)8-3/h1-2H2
(3)InChIKey: PIYNUZCGMLCXKJ-UHFFFAOYAT