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CAS No.: | 450-88-4 |
---|---|
Name: | 2-Bromo-5-fluoroanisole |
Article Data: | 34 |
Molecular Structure: | |
Formula: | C7H6BrFO |
Molecular Weight: | 205.026 |
Synonyms: | 1-Bromo-4-fluoro-2-methoxybenzene;2-Bromo-5-fluoroanisole;Anisole,6-bromo-3-fluoro- (8CI); |
Density: | 1.531 g/cm3 |
Boiling Point: | 187.9 °C at 760 mmHg |
Flash Point: | 80.2 °C |
Hazard Symbols: | Xn |
Risk Codes: | 36/37/38-36-22 |
Safety: | 26-36/37/39 |
PSA: | 9.23000 |
LogP: | 2.59680 |
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 60℃; for 2h; | 100% |
With potassium carbonate In acetone at 60℃; for 2h; | 100% |
With potassium carbonate In acetone at 60℃; for 2h; | 100% |
Conditions | Yield |
---|---|
Stage #1: 4-fluoro-2-methoxyaniline With sodium nitrite In water at -5 - 0℃; Stage #2: With hydrogen bromide; copper(I) bromide In water at 105℃; | 93% |
Diazotization; |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h; | 93% |
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 3h; | |
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 3h; |
2,4-difluorobromobenzene
potassium methanolate
1-bromo-4-fluoro-2-methoxybenzene
Conditions | Yield |
---|---|
In tetrahydrofuran at 65 - 68℃; for 5h; | 93% |
In tetrahydrofuran at 65 - 68℃; for 5h; | 93% |
In tetrahydrofuran at 65℃; for 4h; | 90% |
Conditions | Yield |
---|---|
With potassium phosphate; tetrabuthylammonium tribromide In acetonitrile at 100℃; for 16h; | 75% |
Conditions | Yield |
---|---|
Stage #1: methanol With sodium hydride In tetrahydrofuran at 0℃; for 15h; Stage #2: 2,4-difluorobromobenzene In tetrahydrofuran at 20℃; for 17h; Further stages.; | 42% |
2,4-difluorobromobenzene
potassium methanolate
A
1-Bromo-2,4-dimethoxybenzene
B
1-bromo-2-fluoro-4-methoxybenzene
C
1-bromo-4-fluoro-2-methoxybenzene
Conditions | Yield |
---|---|
In tetrahydrofuran at 65 - 68℃; for 22h; Inert atmosphere; regioselective reaction; | A 9% B n/a C n/a |
1-fluoro-3-methoxybenzene
A
1-bromo-2-fluoro-4-methoxybenzene
B
1-bromo-4-fluoro-2-methoxybenzene
Conditions | Yield |
---|---|
With bromine; tetramethylammonium bromide In liquid sulphur dioxide at -23℃; Product distribution; Rate constant; | |
With bromine; iron In chloroform at -60℃; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
N-Formylpiperidine
1-fluoro-3-methoxybenzene
A
2-fluoro-4-methoxy-benzaldehyde
B
1-bromo-4-fluoro-2-methoxybenzene
C
2-methoxy-4-fluorobenzaldehyde
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: iron; aqueous acetic acid 2: Diazotization View Scheme | |
Multi-step reaction with 2 steps 1.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 30 - 35 °C / 3750.38 - 7500.75 Torr / Autoclave; Inert atmosphere 2.1: sodium nitrite / water / -5 - 0 °C 2.2: 105 °C View Scheme |
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IUPAC Name: 1-bromo-4-fluoro-2-methoxybenzene
Molecular Formula: C7H6BrFO
Molecular Weight: 205.02g/mol
Density: 1.531g/cm3
Boiling Point: 187.9 °C at 760 mmHg
Flash Point: 80.2 °C
Freely Rotating Bonds: 1
Polar Surface Area: 9.23 Å2
Index of Refraction: 1.518
Molar Refractivity: 40.61 cm3
Molar Volume: 133.8 cm3
Polarizability: 16.1 ×10-24 cm3
Surface Tension: 33.3 dyne/cm
Enthalpy of Vaporization: 40.67 kJ/mol
Vapour Pressure: 0.849 mmHg at 25°C
The synonyms of 2-Bromo-5-fluoroanisole (450-88-4) are Buttpark 87\07-62 ; 2-Bromo-5-fluoroanisole ; 1-Bromo-4-fluoro-2-methoxybenzene ; 2-Bromo-5-fluoroanisole98+% .Product categories of 2-Bromo-5-fluoroanisole (450-88-4) is Anisole .The molecular structure of 2-Bromo-5-fluoroanisole (450-88-4) is .
2-Bromo-5-fluoroanisole (450-88-4) can be used in organic synthesis.
Hazard Symbols: Xn
Risk Statements: 36/37/38-36-22
22: Harmful if swallowed
36: Irritating to the eyes
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36/37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection