Products Categories
| CAS No.: | 452-06-2 |
|---|---|
| Name: | 2-Aminopurine |
| Article Data: | 23 |
| Molecular Structure: | |
|
|
|
| Formula: | C5H5N5 |
| Molecular Weight: | 135.128 |
| Synonyms: | 1H-Purin-2-amine(9CI);Purine, 2-amino- (6Cl,8Cl);2-Aminopurine;Isoadenine;NSC 24129;SQ22451;CCRIS 759;Purine, 2-amino-; |
| EINECS: | 207-197-4 |
| Density: | 1.612 g/cm3 |
| Melting Point: | 280-282 °C(lit.) |
| Boiling Point: | 616.3 °C at 760 mmHg |
| Flash Point: | 362.9 °C |
| Solubility: | Soluble in acid, slightly soluble in hot ethanol, insoluble in alkaline solution |
| Appearance: | White to light yellow crystal powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 22-36/37/38-20/21/22 |
| Safety: | 22-36-26 |
| PSA: | 80.48000 |
| LogP: | 0.51630 |
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 33512-51-5
2-(methylthio)-9H-purine
- 452-06-2
9H-purin-2-amine
| Conditions | Yield |
|---|---|
| With potassium amide In ammonia for 70h; Mechanism; 2-halogenated purines; | 90% |
- 10310-21-1
2-Amino-6-chloropurin
- 452-06-2
9H-purin-2-amine
| Conditions | Yield |
|---|---|
| In hydrogenchloride at 50℃; electrolysis, -0.75V, initial current 50-60 mA; | 85% |
| palladium on charcoal In sodium hydroxide; water |
- 452-06-2
9H-purin-2-amine
| Conditions | Yield |
|---|---|
| With methylamine In methanol at 100℃; for 17h; | 80% |
| Conditions | Yield |
|---|---|
| With ammonia In methanol at 100℃; for 17h; Mechanism; Product distribution; | A 70% B 20% |
| Conditions | Yield |
|---|---|
| 1.) RT, 6 h, 2.) reflux, 30 min; | 61% |
A
- 33512-51-5
2-(methylthio)-9H-purine
B
- 452-06-2
9H-purin-2-amine
| Conditions | Yield |
|---|---|
| With ammonia In methanol at 100℃; for 17h; Product distribution; Mechanism; ANRORC and no ANRORC mechanism determined by reaction with 15N labelled ammonia; var. temp. and time; | A 55% B 25% |
- 61991-08-0
amipurimycin
- 452-06-2
9H-purin-2-amine
| Conditions | Yield |
|---|---|
| With trifluoroacetic acid at 130℃; | 48% |
- 452-06-2
9H-purin-2-amine
| Conditions | Yield |
|---|---|
| With nickel In water for 7.5h; Heating; | 35.7% |
- 107550-74-3
iso-2',3'-dideoxyadenosine
A
- 122999-44-4
2,3-Didesoxy-β-D-glycero-pentofuranose
B
- 452-06-2
9H-purin-2-amine
| Conditions | Yield |
|---|---|
| With hydrogenchloride at 22℃; rate of hydrolysis relative to dideoxyadenosine; |
- 3616-24-8
2-amino-9-(β-D-2'-deoxyribofuranosyl)-purine
A
- 18620-60-5
2,4-diamino-5-formamidopyrimidine
B
- 452-06-2
9H-purin-2-amine
| Conditions | Yield |
|---|---|
| With sodium cacodylate buffer; water at 110℃; for 22h; Kinetics; Thermodynamic data; Mechanism; ΔH(excit.); var. temp. and times; |
What can I do for you?
Get Best Price
Specification
The 2-Aminopurine with CAS registry number of 452-06-2 is also known as Purine, 2-amino- (6Cl,8Cl). The IUPAC name is 7H-Purin-2-amine. It belongs to product categories of Pyrimidine; Purine; Nucleotides and Nucleosides; Purines; Biochemistry; Nucleobases and Their Analogs; Nucleosides, Nucleotides & Related Reagents; Nucleic Acids; Bases & Related Reagents; Nucleotides; Nucleoside Analogs; Nucleosides, Nucleotides, Oligonucleotides; Biochemicals and Reagents. Its EINECS registry number is 207-197-4. In addition, the formula is C5H5N5 and the molecular weight is 135.15.
Physical properties about 2-Aminopurine are: (1)ACD/LogP: -0.52; (2)ACD/LogD (pH 5.5): -0.57; (3)ACD/LogD (pH 7.4): -0.53; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 11.11; (7)ACD/KOC (pH 7.4): 12.31; (8)#H bond acceptors: 5; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 0; (11)Index of Refraction: 1.837; (12)Molar Refractivity: 37.03 cm3; (13)Molar Volume: 83.8 cm3; (14)Surface Tension: 122.7 dyne/cm; (15)Density: 1.612 g/cm3; (16)Flash Point: 362.9 °C; (17)Enthalpy of Vaporization: 91.41 kJ/mol; (18)Boiling Point: 616.3 °C at 760 mmHg; (19)Vapour Pressure: 4.03E-15 mmHg at 25 °C.
Preparation of 2-Aminopurine: it is prepared by reaction of 1,2-diaminopurinium mesitylenesulphonate. The reaction needs reagent methylamine and solvent methanol at the temperature of 100 °C for 17 hours. The yield is about 80%. It is a fluorescent molecular marker used in nucleic acid research and sometimes used in the laboratory for mutagenesis.
Uses of 2-Aminopurine: it is used to produce 2-benzylaminopurine by reaction with phenylmethanol; sodium salt. The reaction occurs at the temperature of 130 °C for 17 hours. The yield is about 63%.
When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes, respiratory system and skin. What's more, it is harmful by inhalation, in contact with skin and if swallowed. During using it, wear suitable protective clothing and do not breathe dust. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
1. Canonical SMILES: C1=C2C(=NC(=N1)N)N=CN2
2. InChI: InChI=1S/C5H5N5/c6-5-7-1-3-4(10-5)9-2-8-3/h1-2H,(H3,6,7,8,9,10)
3. InChIKey: MWBWWFOAEOYUST-UHFFFAOYSA-N
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD50 | intraperitoneal | 270mg/kg (270mg/kg) | Japanese Kokai Tokyo Koho Patents. Vol. #78-55733, | |
| rat | LD50 | oral | 723mg/kg (723mg/kg) | Japanese Kokai Tokyo Koho Patents. Vol. #78-55733, |