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CAS No.: | 4695-13-0 | ||||||
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Name: | 2,2-DIPHENYLACETAMIDE | ||||||
Article Data: | 56 | ||||||
Molecular Structure: | |||||||
Formula: | C14H13 N O | ||||||
Molecular Weight: | 211.263 | ||||||
Synonyms: | Acetamide,2,2-diphenyl- (6CI,7CI,8CI); 2,2-Diphenylacetamide; Diphenylacetic acid amide;NSC 29731; a,a-Diphenylacetamide | ||||||
Density: | 1.13g/cm3 | ||||||
Melting Point: | 164-167°C | ||||||
Boiling Point: | 391°Cat760mmHg | ||||||
Flash Point: | 190.3°C | ||||||
Hazard Symbols: | R22:Harmful if swallowed.; | ||||||
Risk Codes: | 22 | ||||||
Safety: |
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PSA: | 43.09000 | ||||||
LogP: | 3.00410 |
Conditions | Yield |
---|---|
With pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate In 1,4-dioxane at 20℃; for 12h; | 95% |
With magnesium(II) nitrate hexahydrate; urea In octane at 120℃; for 24h; Reagent/catalyst; | 92% |
Stage #1: 2,2-diphenylacetic acid With thionyl chloride In tetrahydrofuran at 50℃; for 1h; Stage #2: With ammonium hydroxide In tetrahydrofuran at 0℃; for 0.0833333h; | 86% |
Conditions | Yield |
---|---|
With sodium hydroxide; poly(ethylene glycol)-400 for 0.025h; microwave irradiation; | 94% |
With tetra(n-butyl)ammonium hydroxide In ethanol; water at 80℃; for 12h; Green chemistry; chemoselective reaction; | 92% |
With Os(hydride)6(triisopropylphosphine)2; water In tetrahydrofuran-d8 at 100℃; for 4h; Inert atmosphere; | 79% |
1-(1H-benzo[d][1,2,3]triazol-1-yl)-2,2-diphenylethan-1-one
2,2-diphenylacetamide
Conditions | Yield |
---|---|
With ammonium hydroxide In tetrahydrofuran; ethanol at 20℃; for 4h; | 90% |
C19H21N3O
2,2-diphenylacetamide
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 0.166667h; | 85% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 0.166667h; | 85% |
Conditions | Yield |
---|---|
With ammonia In methanol at 55℃; for 0.5h; | 80% |
With diethyl ether; ammonia | |
With ammonia |
2-diphenylmethyleneoxazolidine-4,5-dione
2,2-diphenylacetamide
Conditions | Yield |
---|---|
With phosphorous acid trimethyl ester In benzene for 8h; Heating; | 80% |
ethyl 3-aminobut-2-enoate
2-diazo-1,2-diphenylethan-1-one
A
2,2-diphenylacetamide
B
(Z)-3-Amino-2-diphenylacetyl-but-2-enoic acid ethyl ester
C
(Z)-3-Diphenylacetylamino-but-2-enoic acid ethyl ester
Conditions | Yield |
---|---|
In dichloromethane for 168h; Ambient temperature; | A 23% B 42% C 16% |
4-Aminopent-3-en-2-one
2-diazo-1,2-diphenylethan-1-one
A
2,2-diphenylacetamide
B
3-[1-Amino-eth-(E)-ylidene]-1,1-diphenyl-pentane-2,4-dione
Conditions | Yield |
---|---|
In dichloromethane for 168h; Mechanism; Ambient temperature; other primary and secondary enaminones; | A 10% B 40% |
In dichloromethane for 168h; Ambient temperature; | A 10% B 40% |
In dichloromethane for 168h; Ambient temperature; | A 10% B 10% |
benzil monohydrazone
A
2,2-diphenylacetamide
B
benzil monoazine
C
benzil-mono-benzhydrylidenehydrazone
D
3,4-diphenyl-1,2,5-thiadiazole
Conditions | Yield |
---|---|
With tetrasulphur tetranitride In toluene for 24h; Heating; | A 3% B 5% C 20% D 8% |
With tetrasulphur tetranitride In toluene for 24h; Mechanism; Heating; | A 3% B 5% C 20% D 8% |
Conditions | Yield |
---|---|
With pyridine; ammonium hydroxide; sulfur at 230℃; | |
Multi-step reaction with 3 steps 1: glacial acetic acid; concentrated nitric acid 2: hydrochloride of tin dichloride; alcohol 3: KOH; alcohol View Scheme |