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| CAS No.: | 51-12-7 |
|---|---|
| Name: | NIALAMIDE |
| Molecular Structure: | |
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|
|
| Formula: | C16H18 N4 O2 |
| Molecular Weight: | 298.345 |
| Synonyms: | Isonicotinicacid, 2-[2-(benzylcarbamoyl)ethyl]hydrazide (6CI,7CI,8CI); 1-[2-(Benzylcarbamoyl)ethyl]-2-isonicotinoylhydrazine;Espril; N1-Beta-Benzylcarbamoyl-ethyl-N2-isonicotinoyl-hydrazine; NSC 124514;Nialamid; Nialamide; Niamid; Niamidal; Niamide; Niaquitil; Niazin; Novazid;Nuredal; Nyezin |
| Density: | 1.203g/cm3 |
| Melting Point: |
152-154 °C(lit.) |
| Boiling Point: | 538.1°Cat760mmHg |
| Flash Point: | 279.2°C |
| Hazard Symbols: | Toxic in overdose. |
| Risk Codes: | R20/21/22; R36/37/38; R40 |
| Safety: | Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Mutation data reported. Experimental reproductive effects. An antidepressant. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 83.12000 |
| LogP: | 2.19520 |
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Chemistry
Product Name: Nialamide
CAS: 51-12-7
The Molecular formula of Nialamide (CAS NO.51-12-7): C16H18N4O2
The Molecular Weight of Nialamide (CAS NO.51-12-7): 298.34
The Molecular Structure of Nialamide (CAS NO.51-12-7):
Density: 1.203 g/cm3
Flash Point: 279.2 °C
Boiling Point: 538.1 °C at 760 mmHg
Melting Point: 152-154 °C(lit.)
Index of Refraction: 1.589
Molar Refractivity: 83.57 cm3
Molar Volume: 247.9 cm3
Polarizability: 33.13×10-24cm3
Surface Tension: 52.3 dyne/cm
Enthalpy of Vaporization: 81.52 kJ/mol
Vapour Pressure: 1.19E-11 mmHg at 25°
Toxicity Data With Reference
| 1. | mma-sat 10 µg/plate | PLRCAT Pharmacological Research Communications. 12 (1980),423. | ||
| 2. | mmo-sat 10 µg/plate | MUREAV Mutation Research. 40 (1976),305. | ||
| 3. | dnr-esc 27 µmol/plate | JTEHD6 Journal of Toxicology and Environmental Health. 9 (1982),287. | ||
| 4. | oms-bcs 10 mmol/L | MUREAV Mutation Research. 5 (1968),343. | ||
| 5. | dnd-mus-ipr 2450 µmol/kg | CNREA8 Cancer Research. 41 (1981),1469. | ||
| 6. | sce-mus-ipr 435 mg/kg | JTEHD6 Journal of Toxicology and Environmental Health. 9 (1982),287. | ||
| 7. | orl-rat LD50:1700 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 1 (1959),524. | ||
| 8. | ipr-rat LD50:760 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 1 (1959),524. | ||
| 9. | orl-mus LD50:590 mg/kg | 27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,269. | ||
| 10. | ipr-mus LD50:200 mg/kg | MPHEAE Medicina et Pharmacologia Experimentalis. 16 (1967),267. | ||
| 11. |
Consensus Reports
EPA Genetic Toxicology Program.
Safety Profile
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Mutation data reported. Experimental reproductive effects. An antidepressant. When heated to decomposition it emits toxic fumes of NOx.
Safety Information about Nialamide (CAS NO.51-12-7):
Hazard Codes:
Xn: 
Risk Statements about Nialamide (CAS NO.51-12-7):
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
R40: Limited evidence of a carcinogenic effect.
Safety Statements about Nialamide (CAS NO.51-12-7):
S22: Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
F10: Keep under argon.
RIDADR: 3249
WGK Germany: 3
RTECS: NS1225000
HazardClass: 6.1(b)
PackingGroup: III
Specification
Nialamide with CAS number of 51-12-7 is also named as 1-(2-(Benzylcarbamoyl)ethyl)-2-isonicotinoylhydrazine ; 2-(2-(Benzylcarbamoyl)ethyl)hydrazide isonicotinic acid ; 2-(2-(Benzylcarbamyl)ethyl)hydrazide isonicotinic acid ; 4-Pyridinecarboxylic acid 2-(3-oxo-3- ; ((phenylmethyl)amino)propyl)hydrazide ; 5-22-02-00251 (Beilstein Handbook Reference) ; BEIH ; BRN 0492941 ; CCRIS 3512 ; Delmoneurina ; Delmoneurinaesprilisalizina ; EINECS 200-079-3 ; Espril ; Isalizina ; Isonicotinic acid 2-((2-benzylcarbamoyl)ethyl)hydrazide ; Isonicotinic acid, 2-(2-(benzylcarbamoyl)ethyl)hydrazide ; Mygal ; N(sup 1)-beta-Benzylcarbamoylethyl-N(sup 2)-isonicotinoylhydrazine ; N(sup1)-beta-Benzylcarbamoylethyl-N(sup2)-isonicotinoylhydrazine ; N-(2-(Benzylcarbamyl)ethylamino)isonicotinamide ; N-Benzyl-beta-(isonicotinoylhydrazine)propionamide ; N-Benzyl-beta-(isonicotinylhydrazino)propionamide ; N-Isonicotinoyl-N'(beta-N-benzylcarboxamidoethyl)hydrazine ; NSC 124514 ; Nialamid ; Nialamida ; Nialamida [INN-Spanish] ; Nialamide ; Nialamidum ; Nialamidum [INN-Latin] ; Niamid ; Niamidal ; Niamide ; Niaquitil ; Niazin ; Novazid ; Nuredal ; Nyazin ; P 1133 ; Psicodisten ; Surgex ; UNII-T2Q0RYM725 . Nialamide is sometimes used in the treatment of trigeminal neuralgia. It has also been studied for alcoholism, dermatomally distributed vitiligo, irregular menstruation, angina, cerebrovascular disorders, and the prevention of streptomycin-induced deafness.Side effects of nialamide include euphoria, psychomotor agitation, insomnia, anxiety, headache, vertigo, tremor, hyperreflexia, manic state, arterial hypotension, orthostatic hypotension, arterial hypertension, palpitations, hyperhidrosis, dry mouth, nausea, vomiting, epigastric pain, constipation, vision problems, retrobulbar optic neuritis, polyneuritis, weight gain, acute cardiac insufficiency, tachycardia, peripheral neuropathy, jaundice, hepatomegaly, hyperbilirubinemia, urinary retention, elevated transaminases, hepatitis, hepatocellular insufficiency, cutaneous eruption, impotence, and delayed ejaculation.