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CAS No.: | 519-37-9 |
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Name: | 7-(2-HYDROXYETHYL)THEOPHYLLINE |
Article Data: | 15 |
Molecular Structure: | |
Formula: | C9H12N4O3 |
Molecular Weight: | 224.219 |
Synonyms: | Theophylline,7-(2-hydroxyethyl)- (7CI,8CI);7-(2-Hydroxyethyl)-1,3-dimethylxanthine;7-(2-Hydroxyethyl)theophylline;7-(Hydroxyethyl)theophylline;7-(b-Hydroxyethyl)theophylline;7-Theophyllineethanol;Aethophyllinum;Ascorphylline;Bio-phylline;Cordalin;Corophyllin-N;Dilaphyllin;Etofylline;Etophyllin;Etophylline;Frekaphyllin;Hydroxyethyltheophylline;KT 200G;NSC 113373;Oxphylline;Oxyethophylline;Oxyethyltheophylline;Oxyphyllin;Oxyphylline;Oxytheonyl;Phyllocormin N;Soluphylline; |
EINECS: | 208-269-8 |
Density: | 1.51 g/cm3 |
Melting Point: | 163 °C |
Boiling Point: | 495.5 °C at 760 mmHg |
Flash Point: | 253.5 °C |
Solubility: | 2.991g/L(temperature not stated) |
Hazard Symbols: | Xi,Xn |
Risk Codes: | 22-36/37/38 |
Safety: | 36-36/37-26 |
PSA: | 82.05000 |
LogP: | -1.57400 |
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Chemistry informtion about Hydroxyethyltheophylline (CAS NO.519-37-9) is:
IUPAC Name: 7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione
Synonyms: Etofylline ; Beta-Hydroxyethyltheophylline ; Biophylline ; 7-(A-Hydroxyethyl)Theophylline ; 7-(Beta-Hydroxyethyl)Theophylline ; 7-(2-Hydroxyethyl)Theophylline ; 1,3-Dimethyl-7-(Beta-Hydroxyethyl)Xanthine ; 1,3-Dimethyl-7-[2-Hydroxyethyl]-Xanthine
MF: C9H12N4O3
MW: 224.22
EINECS: 208-269-8
Melting Point: 163°C
Density: 1.51 g/cm3
Flash Point: 253.5 °C Boiling Point: 495.5 °C at 760 mmHg
Vapour Pressure: 1.23E-10 mmHg at 25°C
Enthalpy of Vaporization: 80.36 kJ/mol
Merck: 3878
Following is the molecular structure of Hydroxyethyltheophylline (CAS NO.519-37-9) is:
Hydroxyethyltheophylline (CAS NO.519-37-9) is useful synthetic intermediate in the preparation of 7-substituted xanthines.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 400mg/kg (400mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 190, 1958. | |
mouse | LD50 | intravenous | 344mg/kg (344mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957. | |
mouse | LD50 | oral | 400mg/kg (400mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1173, 1977. | |
mouse | LD50 | subcutaneous | 400mg/kg (400mg/kg) | Behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: respiratory stimulation skin and appendages (skin): sweating: other | Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 649, 1954. |
rat | LD50 | intravenous | 486mg/kg (486mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957. | |
rat | LD50 | oral | 710mg/kg (710mg/kg) | Liver: other changes | Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 2023, 1980. |
rat | LD50 | subcutaneous | 176mg/kg (176mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957. |
Poison by ingestion, subcutaneous, intravenous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also THEOPHYLLINE.
Hazard Codes:
Xn: Harmful
Xi: Irritant
Risk Statements:
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements:
S36: Wear suitable protective clothing.
S36/37: Wear suitable protective clothing and gloves.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: XH5850000
Hydroxyethyltheophylline (CAS NO.519-37-9) is a white solid.