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519-37-9

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519-37-9 Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 519-37-9 differently. You can refer to the following data:
1. An inhibitor of 3’,5’-Cyclic Nucleotide Phosphodiesterase. Therapeutically, this compound has diuretic, muscle relaxant, bronchial dilation and CNS stimulant activities.
2. Useful synthetic intermediate in the preparation of 7-substituted xanthines.
3. Cardiac analeptic;Phosphodiesterase inhibitor

Therapeutic Function

Antihyperlipidemic

Biochem/physiol Actions

Pharmacological profile similar to theophylline.

Check Digit Verification of cas no

The CAS Registry Mumber 519-37-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 9 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 519-37:
(5*5)+(4*1)+(3*9)+(2*3)+(1*7)=69
69 % 10 = 9
So 519-37-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H12N4O3/c1-11-7-6(8(15)12(2)9(11)16)13(3-4-14)5-10-7/h5,14H,3-4H2,1-2H3

519-37-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (H0402)  7-(2-Hydroxyethyl)theophylline  >98.0%(HPLC)(N)

  • 519-37-9

  • 25g

  • 690.00CNY

  • Detail
  • TCI America

  • (H0402)  7-(2-Hydroxyethyl)theophylline  >98.0%(HPLC)(N)

  • 519-37-9

  • 500g

  • 3,590.00CNY

  • Detail
  • Sigma-Aldrich

  • (E2500000)  Etofylline  European Pharmacopoeia (EP) Reference Standard

  • 519-37-9

  • E2500000

  • 1,880.19CNY

  • Detail
  • USP

  • (1653060)  Theophylline Related Compound F  United States Pharmacopeia (USP) Reference Standard

  • 519-37-9

  • 1653060-25MG

  • 14,847.30CNY

  • Detail

519-37-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-(2-Hydroxyethyl)theophylline

1.2 Other means of identification

Product number -
Other names 1,3-Dimethyl-7-(2-hydroxyethyl)xanthine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:519-37-9 SDS

519-37-9Relevant articles and documents

Method for treating benign prostate hyperplasia

-

, (2008/06/13)

A method of treating and/or preventing renal dysfunction in a patient, such as renal colic or contrast nephropathy by administering to a patient, a compound of the formula: is described herein. Administration of dyphylline in a sustained release oral dosage form is preferred.

Method of kidney treatment

-

, (2008/06/13)

A method of treating and/or preventing renal dysfunction in a patient, such as renal colic or contrast nephropathy by administering to a patient, a compound of the formula: is described herein. Administration of dyphylline in a sustained release oral dosage form is preferred.

Metabolism and pharmacokinetics of etofylline clofibrate, a new hypolipidaemic agent

Luecker,Wetzelsberger,Erking,Donike

, p. 2045 - 2053 (2007/10/02)

Upon investigations on metabolism and pharmacokinetics of 1-(theophyllin-7-yl)-ethyl-2-[2-(p-chlorophenoxy)-2-methyl-propionate] (etofylline clofibrate, ML 1024, Duolip) is reported. As can be seen from in vivo tests in rats and dogs ML 1024 is cleaved to the metabolites clofibric acid and etofylline. This could be further demonstrated in vitro by incubation with lipases and human serum. The phrmacokinetic parameters of the metabolites after oral application of 2 capsules Duolip, corresponding to 500 mg etofylline clofibrate, were evaluated in 7 healthy volunteers. The serum fluctuations of the main metabolites could be adapted to an open two-compartment model (clofibric acid) and to a one-compartment model (etofylline). The following mean values were found: the invasion half-life is 1 h 4 min for clofibric acid and 1 h 52 min for etofylline. The maximum concentration after approximately 4 h is 22.75 μg/ml for clofibric acid and 6.57 μg/ml for etofylline. The elimination half-life is 12.12 h for clofibric and 4.33 h for etofylline. Via urine 20 mg clofibric acid and 15.7 mg etofylline were excreted within 8 hr. The elimination process after 8 h is not yet terminated.

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