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52-70-0

Basic Information
CAS No.: 52-70-0
Name: 6alpha,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate
Molecular Structure:
Molecular Structure of 52-70-0 (6alpha,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate)
Formula: C23H28 F2 O6
Molecular Weight: 438.469
Synonyms: Pregna-1,4-diene-3,20-dione,6a,9-difluoro-11b,17,21-trihydroxy-, 21-acetate(6CI,8CI)
Density: 1.35g/cm3
Boiling Point: 578.1°Cat760mmHg
Flash Point: 303.4°C
PSA: 100.90000
LogP: 2.16850
Synthetic route
2964-95-6

21-acetoxy-6α,9-difluoro-11β,17-dihydroxy-pregn-4-ene-3,20-dione

52-70-0

21-acetoxy-6α,9-difluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
With selenium(IV) oxide
3802-45-7

21-acetoxy-9,11β-epoxy-6α-fluoro-17-hydroxy-9β-pregna-1,4-diene-3,20-dione

52-70-0

21-acetoxy-6α,9-difluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
With hydrogen fluoride
106545-20-4

17α,21-diacetoxy-5α,6-oxide-3,3-ethylenedioxypregnan-20-one

52-70-0

21-acetoxy-6α,9-difluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: boron fluoride; diethyl ether; benzene
2: toluene-4-sulfonic acid
3: HCl; acetic acid
4: methanol.KOH
5: durch Inkubation mit Rinder-Nebennieren-Suspension und anschliessender Acetylierung
6: methanesulfonyl chloride; pyridine; DMF
7: N-bromo-acetamide; dioxane; aqueous perchloric acid / Erwaermen einer Loesung des Reaktionsprodukts in Aceton mit Kaliumacetat
8: HF / dann mit Acetanhydrid
9: SeO2
View Scheme
1807-15-4

17,21-diacetoxy-4-pregnene-3,20-dione

52-70-0

21-acetoxy-6α,9-difluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: toluene-4-sulfonic acid / Entfernen des entstehenden Butanons
2: chloroform; monoperoxyphthalic acid; diethyl ether
3: boron fluoride; diethyl ether; benzene
4: toluene-4-sulfonic acid
5: HCl; acetic acid
6: methanol.KOH
7: durch Inkubation mit Rinder-Nebennieren-Suspension und anschliessender Acetylierung
8: methanesulfonyl chloride; pyridine; DMF
9: N-bromo-acetamide; dioxane; aqueous perchloric acid / Erwaermen einer Loesung des Reaktionsprodukts in Aceton mit Kaliumacetat
10: HF / dann mit Acetanhydrid
11: SeO2
View Scheme
570-41-2

pregna-4,9(11)-diene-6α-fluoro-3,20-dione-17-hydroxy-21-acetate

52-70-0

21-acetoxy-6α,9-difluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-bromo-acetamide; dioxane; aqueous perchloric acid / Erwaermen einer Loesung des Reaktionsprodukts in Aceton mit Kaliumacetat
2: HF / dann mit Acetanhydrid
3: SeO2
View Scheme
2967-03-5

5α-hydroxy-17α,21-diacetoxy-6β-fluoropregnane-3,20-dione

52-70-0

21-acetoxy-6α,9-difluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: HCl; acetic acid
2: methanol.KOH
3: durch Inkubation mit Rinder-Nebennieren-Suspension und anschliessender Acetylierung
4: methanesulfonyl chloride; pyridine; DMF
5: N-bromo-acetamide; dioxane; aqueous perchloric acid / Erwaermen einer Loesung des Reaktionsprodukts in Aceton mit Kaliumacetat
6: HF / dann mit Acetanhydrid
7: SeO2
View Scheme
3827-45-0

6α-fluoro-17,21-dihydroxy-pregn-4-ene-3,20-dione

52-70-0

21-acetoxy-6α,9-difluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: durch Inkubation mit Rinder-Nebennieren-Suspension und anschliessender Acetylierung
2: methanesulfonyl chloride; pyridine; DMF
3: N-bromo-acetamide; dioxane; aqueous perchloric acid / Erwaermen einer Loesung des Reaktionsprodukts in Aceton mit Kaliumacetat
4: HF / dann mit Acetanhydrid
5: SeO2
View Scheme
1058-55-5

21-acetoxy-6α-fluoro-11β,17-dihydroxy-pregn-4-ene-3,20-dione

52-70-0

21-acetoxy-6α,9-difluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: methanesulfonyl chloride; pyridine; DMF
2: N-bromo-acetamide; dioxane; aqueous perchloric acid / Erwaermen einer Loesung des Reaktionsprodukts in Aceton mit Kaliumacetat
3: HF / dann mit Acetanhydrid
4: SeO2
View Scheme
3793-12-2

17,21-diacetoxy-6α-fluoro-pregn-4-ene-3,20-dione

52-70-0

21-acetoxy-6α,9-difluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: methanol.KOH
2: durch Inkubation mit Rinder-Nebennieren-Suspension und anschliessender Acetylierung
3: methanesulfonyl chloride; pyridine; DMF
4: N-bromo-acetamide; dioxane; aqueous perchloric acid / Erwaermen einer Loesung des Reaktionsprodukts in Aceton mit Kaliumacetat
5: HF / dann mit Acetanhydrid
6: SeO2
View Scheme
3800-29-1, 7793-44-4

21-acetoxy-9,11β-epoxy-6α-fluoro-17-hydroxy-9β-pregn-4-ene-3,20-dione

52-70-0

21-acetoxy-6α,9-difluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HF / dann mit Acetanhydrid
2: SeO2
View Scheme
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  • 6alpha,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate

  • Casno:

    52-70-0

    6alpha,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 3.0-3.0

    DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

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  • Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-6,9-difluoro-11,17-dihydroxy-, (6a,11b)- (9CI)

  • Casno:

    52-70-0

    Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-6,9-difluoro-11,17-dihydroxy-, (6a,11b)- (9CI)

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0

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  • 6alpha,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate

  • Casno:

    52-70-0

    6alpha,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 2.0-2.0

    Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

    Welcome to Taizhou Zhenyu Biotech Co.,LTD , Sister Company of Ningbo Zhenlei Chemical co.,ltd ,is a rapid growing company , We are one of TOP supplier and manufactuer of Human APIs

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  • 6α,?9α-?Difluoroprednisolone 21-Acetate

  • Casno:

    52-70-0

    6α,?9α-?Difluoroprednisolone 21-Acetate

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    The system can just identify the products information in first sheet, it is not be permitted to add or edit new sheet by userself.Our products are required in MG to Gram only. · Pharmaceutical Reference Standards· Traceable workin

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