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CAS No.: | 532-65-0 |
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Name: | ar-Turmerone |
Article Data: | 21 |
Molecular Structure: | |
Formula: | C15H20O |
Molecular Weight: | 216.323 |
Synonyms: | (+)-ar-Turmerone;(6S)-2-methyl-6-(4-methylphenyl)hept-2-en-4-one;Tumerone;(S)-AR-TURMERONE; |
Density: | 0.945g/cm3 |
Boiling Point: | 325.7°Cat760mmHg |
Flash Point: | 121.6°C |
PSA: | 17.07000 |
LogP: | 4.02390 |
(+)-(S)-ar-turmerone
Conditions | Yield |
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With manganese(IV) oxide In tetrachloromethane at 60℃; for 0.5h; | 94% |
With oxalyl dichloride; dimethyl sulfoxide; triethylamine In dichloromethane at -78 - 0℃; Swern oxidation; | 53% |
With pyridinium chlorochromate In dichloromethane for 1h; Ambient temperature; 3A molecular sieves; | 52% |
(S)-(+)-iso-ar-turmerone
(+)-(S)-ar-turmerone
Conditions | Yield |
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With piperidine In diethyl ether | 93% |
Conditions | Yield |
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With potassium carbonate In ethanol at 50℃; for 12h; Inert atmosphere; Schlenk technique; enantioselective reaction; | 89% |
Conditions | Yield |
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Stage #1: 2-methyl-1-propenylbromide With iodine; magnesium In tetrahydrofuran Inert atmosphere; Schlenk technique; Glovebox; Reflux; Stage #2: N-methoxy-N-methyl-3-p-tolyl-butyramide In tetrahydrofuran at -15 - 20℃; for 2h; Inert atmosphere; Schlenk technique; Glovebox; | 88% |
(+)-(S)-ar-turmerone
Conditions | Yield |
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With diethylamine; naphthalen-1-yl-lithium In tetrahydrofuran at -78℃; Inert atmosphere; | 85% |
Conditions | Yield |
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In diethyl ether for 24h; | 69.9% |
2-methylpropen-1-ylmagnesium bromide
(+)-(S)-ar-turmerone
Conditions | Yield |
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Stage #1: (S)-1-(1-methyl-1H-imidazol-2-yl)-3-(p-tolyl)butan-1-one; 2-methylpropen-1-ylmagnesium bromide In tetrahydrofuran at 0 - 20℃; for 2.16667h; Inert atmosphere; Stage #2: With methyl iodide In ethyl acetate at 60℃; for 16h; Inert atmosphere; Stage #3: With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 80℃; Inert atmosphere; | 61% |
Conditions | Yield |
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Stage #1: (S)-2,2'-(2-(p-tolyl)propane-1,1-diyl)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) With 2,2,6,6-tetramethylpiperidinyl-lithium In tetrahydrofuran at 0℃; for 0.25h; Inert atmosphere; Stage #2: Methyl 3,3-dimethylacrylate In tetrahydrofuran at 50℃; for 0.5h; Inert atmosphere; Stage #3: With water In tetrahydrofuran for 0.25h; Inert atmosphere; Acidic conditions; | 40% |
(S)-4-(4-methylphenyl)-2-pentanone
(+)-(S)-ar-turmerone
Conditions | Yield |
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With sodium ethanolate; acetone |
(S)-4-(4-methylphenyl)-2-pentanone
sodium ethanolate
acetone
(+)-(S)-ar-turmerone
Conditions | Yield |
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