Products Categories
| CAS No.: | 53267-01-9 |
|---|---|
| Name: | Cibenzoline |
| Article Data: | 3 |
| Molecular Structure: | |
|
|
|
| Formula: | C18H18 N2 |
| Molecular Weight: | 262.354 |
| Synonyms: | (RS)-Cibenzoline;(?à)-Cibenzoline; Cibenzoline;Cifenline; Ro 22-7796; UP 33-901 |
| EINECS: | 258-453-7 |
| Density: | 1.17 g/cm3 |
| Melting Point: | 103-104° |
| Boiling Point: | 449.2 ºC |
| Flash Point: | 225.5 ºC |
| PSA: | 24.39000 |
| LogP: | 2.75870 |
- 81281-59-67-Benzylideneaminotheophylline
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 717878-06-31-(4-fluorophenyl)-4-nitro-1H-imidazole
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 548773-13-32-amino-4,6-dimethylpyrimidine-5-carboxylic acid
- Total:30 Page 1 of 1 1
What can I do for you?
Get Best Price
Chemistry
Molecular Structure of Cibenzoline (CAS NO.53267-01-9):
.gif)
IUPAC Name: 2-(2,2-Diphenylcyclopropyl)-4,5-dihydro-1H-imidazole
Molecular Formula: C18H18N2
Molecular Weight: 262.35
EINECS: 258-453-7
Melting Point: 103.5 °C
Index of Refraction: 1.655
Molar Refractivity: 81.94 cm3
Molar Volume: 223 cm3
Surface Tension: 47.1 dyne/cm
Density: 1.17 g/cm3
Flash Point: 225.5 °C
Enthalpy of Vaporization: 68.06 kJ/mol
Boiling Point: 449.2 °C at 760 mmHg
Vapour Pressure: 7.75E-08 mmHg at 25 °C
Canonical SMILES: C1CN=C(N1)C2CC2(C3=CC=CC=C3)C4=CC=CC=C4
InChI: InChI=1S/C18H18N2/c1-3-7-14(8-4-1)18(15-9-5-2-6-10-15)13-16(18)17-19-11-12-20-17/h1-10,16H,11-13H2,(H,19,20)
InChIKey: IPOBOOXFSRWSHL-UHFFFAOYSA-N
Classification Code: Anti-arrhythmia agents; Cardiac depressant [anti-arrhythmic]; Cardiovascular Agents
Uses
Cibenzoline (CAS NO.53267-01-9) is an antiarrhythmic. It is not a beta-adrenoceptor antagonist. Cibenzoline restricted slow inward current because it was negatively inotropic, and shifted the relation between [Ca2+]o and force of contractions to the right, and increased A-H conduction time. It completely prevented the shortening of APD90 which induced by h ypoxia, and the shortening of APD50 and APD20 was much attenuated. There was no protection against hypoxic depression of contractions.
Cibenzoline did not affect electrophysiologic properties of the atrium or atrioventricular node. Research has shown that it is very important that check Cibenzoline levels regularly in patients receiving long-term therapy with this drug so as to avoid the possibility of severe drug-induced heart failure.
Specification
Cibenzoline (CAS NO.53267-01-9), its Synonyms are (+-)-2-(2,2-Diphenylcyclopropyl)-2-imidazoline ; 2-(2,2-Diphenylcyclopropyl)-2-imidazoline ; Cibenzolina ; Cibenzolinum ; Cifenline ; Cipralan ; 1H-Imidazole, 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-, (+-)- .