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54240-36-7

Basic Information
CAS No.: 54240-36-7
Name: Mabuterolhydrochloride
Molecular Structure:
Molecular Structure of 54240-36-7 (Mabuterolhydrochloride)
Formula: C13H18 Cl F3 N2 O . Cl H
Molecular Weight: 347.208
Synonyms: Benzenemethanol,4-amino-3-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)-,monohydrochloride (9CI);Broncholin;KF 868;KF 868 (pharmaceutical);dl-Mabuterol hydrochloride;Mabuterol Hydrochloride;
Density: g/cm3
Melting Point: 205-206 °C
Boiling Point: 375.9°Cat760mmHg
Flash Point: 181.1°C
Hazard Symbols: Xi
Risk Codes: 36/37/38
Safety: Poison by intravenous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F, NOx, and HCl.
PSA: 58.28000
LogP: 5.13660
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Chemistry

Product Name: KF-868 (CAS NO.54240-36-7)


Molecular Formula: C13H18ClF3N2O.HCl
Molecular Weight: 347.2g/mol
Mol File: 54240-36-7.mol
Appearance: A solid
Boiling point: 375.9°Cat760mmHg
Flash Point: 181.1 °C
Enthalpy of Vaporization: 65.77 kJ/mol
Vapour Pressure: 2.57E-06 mmHg at 25°C
H-Bond Donor: 4
H-Bond Acceptor: 6

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 27500ug/kg (27.5mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
dog LD50 oral 229mg/kg (229mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
human TDLo oral 1143ng/kg (0.001143mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: HEADACHE
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1697, 1984.
human TDLo oral 60ug/kg/6W (0.06mg/kg) BEHAVIORAL: TREMOR

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1699, 1984.
mouse LD50 intraperitoneal 60mg/kg (60mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
mouse LD50 intravenous 36500ug/kg (36.5mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 652, 1984.
mouse LD50 oral 200mg/kg (200mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
mouse LD50 subcutaneous 113mg/kg (113mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
rabbit LD50 intravenous 18300ug/kg (18.3mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
rabbit LD50 oral 243mg/kg (243mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
rat LD50 intraperitoneal 76300ug/kg (76.3mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
rat LD50 intravenous 26400ug/kg (26.4mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
rat LD50 oral 306mg/kg (306mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.
rat LD50 subcutaneous 117mg/kg (117mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1680, 1984.

Safety Profile

Poison by intravenous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F, NOx, and HCl.

Specification

 KF-868 ,its CAS NO. is 54240-36-7,the synonyms is Mabuterolhcl ; Benzenemethanol, 4-amino-3-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)-, monohydrochloride (9ci) ; Broncholin ; Dl-mabuterol hydrochloride ; KF868 (pharmaceutical) .