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| CAS No.: | 545-55-1 |
|---|---|
| Name: | TEPA |
| Molecular Structure: | |
|
|
|
| Formula: | C6H12 N3 O P |
| Molecular Weight: | 173.155 |
| Synonyms: | Phosphineoxide, tris(1-aziridinyl)- (8CI); APO; Aphoxide; ENT 24915; Imperon Fixer T;NSC 9717; Phosphoric acid triethylene imide; Phosphoric triamide,N,N',N''-tri-1,2-ethanediyl-; TAPO; TEF; TEPA; TEPA (pesticide);Tri-1-aziridinylphosphine oxide; Triaziridinophosphine oxide;Triaziridinylphosphine oxide; Triethylenephosphoramide;Triethylenephosphorotriamide; Tris(1-aziridine)phosphine oxide;Tris(1-aziridinyl)phosphine oxide; Tris(aziridinyl)phosphine oxide |
| EINECS: | 208-892-5 |
| Density: | 1.47 g/cm3 |
| Melting Point: | 41℃ |
| Boiling Point: | 299 °C at 760 mmHg |
| Flash Point: | 134.6 °C |
| Appearance: | colourless granules |
| Hazard Symbols: | Highly toxic, strong irritant to skin and tissue. |
| Safety: | Poison by ingestion, skin contact, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic and neoplastigenic data. Human mutation data reported. A corrosive irritant to the skin, eyes, and mucous membranes. When heated to decomposition it emits very toxic fumes of POx and NOx. Used as an acaricide and in the permanent-press treatment of cotton. |
| PSA: | 35.91000 |
| LogP: | -0.14500 |
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| Conditions | Yield |
|---|---|
| With ammonia; trichlorophosphate; benzene | |
| With triethylamine; trichlorophosphate; benzene |
- 52-24-4
Thiotepa
A
- 545-55-1
N,N',N''-triethylenephosphoramide
B
- 27780-83-2
C6H15Cl3N3OP
C
- 93598-04-0
C6H15Cl3N3PS
D
- 118694-55-6
C6H13ClN3OP
E
- 90877-51-3
C6H13ClN3PS
F
- 93598-03-9
C6H14Cl2N3PS
| Conditions | Yield |
|---|---|
| In hydrogenchloride at 37℃; for 1h; Product distribution; different concentration of acid; |
- 545-55-1
N,N',N''-triethylenephosphoramide
- 13884-65-6
C6H18N3OPS3
| Conditions | Yield |
|---|---|
| With hydrogenchloride; lithium thiophosphate powder In water; N,N-dimethyl-formamide at 25℃; | 92% |
- 545-55-1
N,N',N''-triethylenephosphoramide
- 83822-74-6
C6H15N3O10P4S3(6-)*6Li(1+)
| Conditions | Yield |
|---|---|
| With hydrogenchloride; lithium thiophosphate powder In water for 0.333333h; Ambient temperature; | 62% |
- 545-55-1
N,N',N''-triethylenephosphoramide
- 57856-86-7
C6H15Br3N3OP
| Conditions | Yield |
|---|---|
| With hydrogen bromide Ambient temperature; |
- 545-55-1
N,N',N''-triethylenephosphoramide
| Conditions | Yield |
|---|---|
| With hydrogenchloride; trisodium thiophosphate Ambient temperature; |
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Chemistry
IUPAC Name:1-[bis(aziridin-1-yl)phosphoryl]aziridine
Molecular Formula:C6H12N3OP
Molecular Weight:173.152741 g/mol
Appearance:colourless granules
Density:1.47 g/cm3
Boiling Point:299 °C at 760 mmHg
Flash Point:134.6 °C
EINECS:208-892-5
Synonyms of TRIS-(1-AZIRIDINYL)PHOSPHINE OXIDE(545-55-1):
TEPA;1,1’,1"-phosphinylidynetris-aziridin;1,1’,1’’-phosphinylidynetris-aziridin;1,1’,1’’-phosphinylidynetrisaziridine;1-aziridinylphosphineoxide(tris);a6366;aphoxide;cbc906288;ent24915
Toxicity Data With Reference
Toxicity Information of TRIS-(1-AZIRIDINYL)PHOSPHINE OXIDE(545-55-1):
| 1. | sln-dmg-par 500 µg/kg | EVSRBT Environmental Science Research. 25 (1981),917. | ||
| 2. | cyt-hmn:leu 100 µmol/L | CHROAU Chromosoma. 24 (1968),314. | ||
| 3. | orl-rat LD50:37 mg/kg | BWHOA6 Bulletin of the World Health Organization. 31 (1964),737. | ||
| 4. | skn-rat LD50:87 mg/kg | BWHOA6 Bulletin of the World Health Organization. 31 (1964),737. | ||
| 5. | orl-mus LD50:420 mg/kg | KOBUA3 Kobunshi. High Polymers. 24 (1975),788. | ||
| 6. | ipr-mus LD50:25,500 µg/kg | BJPCAL British Journal of Pharmacology and Chemotherapy. 25 (1965),223. | ||
| 7. | ivn-mus LD50:178 mg/kg | CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#02129 . | ||
| 8. | ivn-dog LDLo:430 µg/kg | CCSUBJ Cancer Chemotherapy Reports, Part 2. 2 (1965),202. | ||
| 9. | ivn-mky LDLo:870 µg/kg | CCSUBJ Cancer Chemotherapy Reports, Part 2. 2 (1965),202. | ||
| 10. | orl-ckn LD50:151 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 16 ( |
Consensus Reports
Safety Profile
RIDADR:2811
HazardClass:6.1(b)
PackingGroup:III
Poison by ingestion, skin contact, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic and neoplastigenic data. Human mutation data reported. A corrosive irritant to the skin, eyes, and mucous membranes. When heated to decomposition it emits very toxic fumes of POx and NOx. Used as an acaricide and in the permanent-press treatment of cotton.