CAS No.56610-72-1,7-MAC Suppliers

Products Categories

Pharmaceutical (81)
Organic Chemicals (28)
Others (10)
Reagent (6)
Materials (2)

Basic Information

Molecular Structure:
CAS No.:	56610-72-1
Name:	7-MAC
Article Data:	11

Formula:	C₂₄H₂₄N₆O₄S₂
Molecular Weight:	524.624
Synonyms:	5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-amino-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,diphenylmethyl ester, (6R-cis)-;Diphenylmethyl 7b-amino-7a-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-3-cephem-4-carboxylate;
EINECS:	611-404-7
Density:	1.5 g/cm³
Melting Point:	120°C(lit.)
Boiling Point:	743.2 °C at 760 mmHg
Flash Point:	403.2 °C
Appearance:	faint yellow to yellow powder
PSA:	176.06000
LogP:	2.74380

Synthetic route

: C31H28N6O5S2

: 56610-72-1
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate

Conditions

Conditions	Yield
With pyridine; bis(trichloromethyl) carbonate In dichloromethane at -25 - 5℃; for 3h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere;	94.1%

: 64278-77-9
(6R-cis)-7-methoxy-3-<<(1-methyl-1-H-tetrazol-5-yl)thio>methyl>-8-oxo<(phenylacetyl)amino>-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

: 56610-72-1
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate

Conditions

Conditions	Yield
With pyridine; phosphorus pentachloride In methanol; dichloromethane at -30 - 5℃; for 4h; Reagent/catalyst;	91%
Stage #1: (6R-cis)-7-methoxy-3-<<(1-methyl-1-H-tetrazol-5-yl)thio>methyl>-8-oxo<(phenylacetyl)amino>-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester With pyridine; phosphorus pentachloride In dichloromethane at 5 - 8℃; for 2h; Stage #2: In methanol at -30 - -10℃; for 2h;	90%

: 137-07-5
2-amino-benzenethiol

: 75072-10-5
(6R,7S)-7-[1-Chloro-but-(E)-ylideneamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

A: 17229-76-4
2-propylbenzo[d]thiazole

B: 56610-72-1
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate

C: 75072-09-2
(6R,7S)-7-Butyrylamino-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions

Conditions	Yield
With pyridine In dichloromethane for 1.5h; Ambient temperature;	A 45% B 15% C 23%

...Expand

: 75072-10-5
(6R,7S)-7-[1-Chloro-but-(E)-ylideneamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

A: 17229-76-4
2-propylbenzo[d]thiazole

B: 56610-72-1
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate

C: 75072-09-2
(6R,7S)-7-Butyrylamino-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions

Conditions	Yield
With pyridine; 2-amino-benzenethiol In dichloromethane for 1.5h; Ambient temperature;	A 45% B 15% C 23%

...Expand

: 137-07-5
2-amino-benzenethiol

: (6R,7S)-7-[5-Benzhydryloxycarbonyl-5-tert-butoxycarbonylamino-1-chloro-pent-(Z)-ylideneamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

A: 56610-72-1
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate

B: 5-Benzothiazol-2-yl-2-tert-butoxycarbonylamino-pentanoic acid benzhydryl ester

Conditions

Conditions	Yield
With pyridine In dichloromethane Ambient temperature;	A 25% B 35%

...Expand

: (6R,7S)-7-[5-Benzhydryloxycarbonyl-5-tert-butoxycarbonylamino-1-chloro-pent-(Z)-ylideneamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

A: 56610-72-1
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate

B: 5-Benzothiazol-2-yl-2-tert-butoxycarbonylamino-pentanoic acid benzhydryl ester

Conditions

Conditions	Yield
With pyridine; 2-amino-benzenethiol In dichloromethane Ambient temperature;	A 25% B 35%

: 56023-19-9
(6R)-7t-(3,5-di-tert-butyl-4-hydroxy-benzylideneamino)-7c-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 56610-72-1
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate

Conditions

Conditions	Yield
With girard's reagent T In methanol; ethyl acetate Ambient temperature;

: 57793-21-2
(6R,7S)-7-(5-Benzhydryloxycarbonyl-5-tert-butoxycarbonylamino-pentanoylamino)-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 56610-72-1
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: phosgene-pyridine / CH2Cl2 / Ambient temperature 2: 25 percent / pyridine / CH2Cl2 / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: phosgene-pyridine / CH2Cl2 / Ambient temperature 2: 25 percent / pyridine, o-amino-benzenethiol / CH2Cl2 / Ambient temperature View Scheme

: 75072-09-2
(6R,7S)-7-Butyrylamino-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 56610-72-1
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: phosgene-pyridine / CH2Cl2 / 3 h / Ambient temperature 2: 15 percent / pyridine, o-amino-benzenethiol / CH2Cl2 / 1.5 h / Ambient temperature View Scheme

: 53090-86-1
7β-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>ceph-3-em-4-oic acid benzhydryl ester

: 56610-72-1
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: (i) benzene, (ii) PbO2, 1,2-dichloroethane, (iii) /BRN= 1098229/, benzene 2: Girard T / ethyl acetate; methanol / Ambient temperature View Scheme

Country:
Business Type:
All

Lab/Research institutions

Trading Company

Manufacturers

Other
Certificate:
Manufacturer

Enterprise Authentication

ISO

GMP

FDA

HALAL

Display:default sort
Suppiers of more reward points first

New supplier

Total:103 Page 1 of 3 1 2 3 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 56610-72-1

Specification

The 7-MAC, with the cas registry number 56610-72-1, has the systematic name of diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. This is a kind of faint yellow to yellow powder and is usually applied as the pharmaceutic intermediate, such as being the stem nucleus of some medicine as cefmetazole sodium, cefotetan.

The characteristics of this chemical are as follows: (1)ACD/LogP: 3.31; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): 3.31; (4)ACD/LogD (pH 7.4): 3.31; (5)#H bond acceptors: 10; (6)#H bond donors: 2; (7)#Freely Rotating Bonds: 10; (8)Polar Surface Area: 176.06; (9)Index of Refraction: 1.733; (10)Molar Refractivity: 139.66 cm³; (11)Molar Volume: 348.5 cm³; (12)Polarizability: 55.36 ×10^-24 cm³; (13)Surface Tension: 65.1 dyne/cm; (14)Density: 1.5 g/cm³; (15)Flash Point: 403.2 °C; (16)Enthalpy of Vaporization: 108.37 kJ/mol; (17)Boiling Point: 743.2 °C at 760 mmHg; (18)Vapour Pressure: 5.89E-22 mmHg at 25°C.

Additionally, you could convert the following datas into the molecular structure:
(1)SMILES:Cn1c(nnn1)SCC2=C(N3C(C(C3=O)(N)OC)SC2)C(=O)OC(c4ccccc4)c5ccccc5
(2)InChI:InChI=1/C24H24N6O4S2/c1-29-23(26-27-28-29)36-14-17-13-35-22-24(25,33-2)21(32)30(22)18(17)20(31)34-19(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,19,22H,13-14,25H2,1-2H3/t22-,24+/m1/s1
(3)InChIKey:QGXKMJVEULWQSB-VWNXMTODBW