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Basic Information
| CAS No.: | 59-14-3 |
|---|---|
| Name: | Broxuridine |
| Article Data: | 27 |
| Molecular Structure: | |
|
|
|
| Formula: | C9H11BrN2O5 |
| Molecular Weight: | 307.101 |
| Synonyms: | (+)-5-Bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione;2'-Deoxy-5-bromouridine;5-Bromo-2'-desoxyuridine;5-Bromodeoxyuridine;5-Bromouracil deoxyriboside;5-Bromouracil-2-deoxyriboside;BRUDR;BUdR;Bromodeoxyuridine;NSC 38297; |
| EINECS: | 200-415-9 |
| Density: | 1.905 g/cm3 |
| Melting Point: | 191-194 °C (dec.)(lit.) |
| Solubility: | 1-5 g/100 mL at 22 ºC |
| Appearance: | white crystalline powder |
| Hazard Symbols: |
 Xn, T
|
| Risk Codes: | 68-36/37/38-63-46-24 |
| Safety: | 36/37/39-26-53-45-36 |
| PSA: | 104.55000 |
| LogP: | -1.06020 |
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Broxuridine
Chemistry
Molecular Formula:C9H11BrN2O5
Molar mass:307.09804g/mol
Structure of Broxuridine(59-14-3):
Synonyms of Broxuridine(59-14-3):5-Bromo-2'-deoxyuridine; 2'-Deoxy-5-bromouridine;URACIL;Bromodeoxyuridine;Broxuridinum;Radibud;5-Bromodesoxyuridine;Bromoouridine;5-Bromodeoxyuridine
Density:1.905 g/cm3
Index of Refraction:1.651
Solubility:NH4OH: 0.1 M at 20 °C, clear, colorless organic solvents alkaline solution.
Water solubility:1-5 g/100 mL at 22 °C
Appearance:White crystalline powder
storage temp:2-8°C
Alpha:31 o (c=1, 0.1N NaOH)
Molar mass:307.09804g/mol
Structure of Broxuridine(59-14-3):
Synonyms of Broxuridine(59-14-3):5-Bromo-2'-deoxyuridine; 2'-Deoxy-5-bromouridine;URACIL;Bromodeoxyuridine;Broxuridinum;Radibud;5-Bromodesoxyuridine;Bromoouridine;5-Bromodeoxyuridine
Density:1.905 g/cm3
Index of Refraction:1.651
Solubility:NH4OH: 0.1 M at 20 °C, clear, colorless organic solvents alkaline solution.
Water solubility:1-5 g/100 mL at 22 °C
Appearance:White crystalline powder
storage temp:2-8°C
Alpha:31 o (c=1, 0.1N NaOH)
Uses
Broxuridine(59-14-3) is a Thymidine analogue used as a mutagen in genetic research. Selectively incorporated into cellular DNA during S-phase.
Toxicity Data With Reference
| 1. | mnt-hmn:fbr 82 µmol/L | MUREAV Mutation Research. 4 (1967),353. | ||
| 2. | cyt-hmn:leu 200 mg/L | ECREAL Experimental Cell Research. 34 (1964),182. | ||
| 3. | msc-hmn:fbr 15 mg/L | CSHSAZ Cold Spring Harbor Symposia on Quantitative Biology. 29 (1965),151. | ||
| 4. | orl-rat LD50:8400 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 4 (1973),467. | ||
| 5. | ipr-rat LD50:1500 mg/kg | ADTEAS Advances in Teratology. 3 (1968),181. | ||
| 6. | scu-rat LD50:3900 mg/kg | TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. 30 (1971),530. | ||
| 7. | ivn-rat LD50:2320 mg/kg | TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. 30 (1971),735. | ||
| 8. | orl-mus LD50:9100 mg/kg | TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. 30 (1971),530. | ||
| 9. | ipr-mus LD50:3050 mg/kg | TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. 30 (1971),530. | ||
| 10. | scu-mus LD50:3500 mg/kg | TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Researc |
Consensus Reports
Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Safety Profile
Moderately toxic by subcutaneous, intravenous, intraperitoneal, and possibly other routes. Mildly toxic by ingestion. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Br− and NOx.
Hazard Codes:Xn
,T
Risk Statements:
24: Toxic in contact with skin
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
46: May cause heritable genetic damage
63: Possible risk of harm to the unborn child
68: Possible risk of irreversible effects
Safety Statements:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
53: Avoid exposure - obtain special instruction before use
Hazard Codes:Xn
,TRisk Statements:
24: Toxic in contact with skin
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
46: May cause heritable genetic damage
63: Possible risk of harm to the unborn child
68: Possible risk of irreversible effects
Safety Statements:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
53: Avoid exposure - obtain special instruction before use
Specification
Stability and Reactivity of Broxuridine(59-14-3):
Conditions to Avoid:Incompatible materials.
Chemical Stability:Stable under normal pressures and temperatures.
Incompatibilities with Other Materials:Strong oxidizing agents.
Hazardous Decomposition Products: Carbon dioxide, nitrogen oxides,hydrogen chloride, carbon monoxide.
Conditions to Avoid:Incompatible materials.
Chemical Stability:Stable under normal pressures and temperatures.
Incompatibilities with Other Materials:Strong oxidizing agents.
Hazardous Decomposition Products: Carbon dioxide, nitrogen oxides,hydrogen chloride, carbon monoxide.