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| CAS No.: | 614-75-5 |
|---|---|
| Name: | 2-Hydroxyphenylacetic acid |
| Article Data: | 67 |
| Molecular Structure: | |
|
|
|
| Formula: | C8H8O3 |
| Molecular Weight: | 152.15 |
| Synonyms: | Aceticacid, (o-hydroxyphenyl)- (8CI);(2-Hydroxyphenyl)acetic acid;(o-Hydroxyphenyl)acetic acid;2-HPAA;Benzeneaceticacid, 2-hydroxy-;NSC 62000; |
| EINECS: | 210-393-2 |
| Density: | 1.319 g/cm3 |
| Melting Point: | 145-147 °C(lit.) |
| Boiling Point: | 328.1 °C at 760 mmHg |
| Flash Point: | 166.5 °C |
| Solubility: | Soluble in Methanol and Water. |
| Appearance: | off-white solid |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| PSA: | 57.53000 |
| LogP: | 1.01930 |
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Chemistry
Molecule structure of 2-Hydroxyphenylacetic acid (CAS NO.614-75-5):
IUPAC Name: 2-(2-Hydroxyphenyl)acetic acid
Molecular Weight: 152.14732 g/mol
Molecular Formula: C8H8O3
Density: 1.321 g/cm3
Melting Point: 145-147 °C(lit.)
Boiling Point: 321.8 °C at 760 mmHg
Flash Point: 162.6 °C
Index of Refraction: 1.59
Molar Refractivity: 38.9 cm3
Molar Volume: 115.1 cm3
Polarizability: 15.42×10-24 cm3
Surface Tension: 60.4 dyne/cm
Enthalpy of Vaporization: 59.5 kJ/mol
Vapour Pressure: 0.00012 mmHg at 25 °C
Water Solubility: 1.32E+05 mg/L
XLogP3: 0.9
H-Bond Donor: 2
H-Bond Acceptor: 3
Rotatable Bond Count: 2
Tautomer Count: 3
Exact Mass: 152.047344
MonoIsotopic Mass: 152.047344
Topological Polar Surface Area: 57.5
Heavy Atom Count: 11
Complexity: 144
Canonical SMILES: C1=CC=C(C(=C1)CC(=O)O)O
InChI: InChI=1S/C8H8O3/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4,9H,5H2,(H,10,11)
InChIKey: CCVYRRGZDBSHFU-UHFFFAOYSA-N
EINECS: 210-393-2
Product Categories: FINE Chemical & INTERMEDIATES; Aromatic Phenylacetic Acids and Derivatives; Aromatics; C8; Carbonyl Compounds; Carboxylic Acids
Uses
2-Hydroxyphenylacetic acid (CAS NO.614-75-5) is used as an important intermediate in pharmaceutical synthesis.
Production
2-Chloro acetic acid reacts with 8-hydroxyquinoline copper (Ⅱ) at the presence of sodium hydroxide, reaction temperature 170 °C, pressure of 650 ~ 700kPa, can get the product.
Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
F: 10-23
Hazard Note: Irritant
HS Code: 29182990
Specification
2-Hydroxyphenylacetic acid (CAS NO.614-75-5) is also named as (2-Hydroxyphenyl)acetic acid ; 2-Hydroxybenzeneacetic acid ; 2-Hydroxyphenylacetate ; 2-Hydroxyphenylacetic acid ; Hydroxyphenylacetic acid ; NSC 62000 ; o-Hydroxy phenylacetic acid ; o-Hydroxyphenylacetic acid . 2-Hydroxyphenylacetic acid (CAS NO.614-75-5) is off-white solid. It insoluble in water, soluble in benzene, toluene and other organic solvents.