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CAS No.: | 616201-80-0 |
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Name: | LorcaserinA |
Article Data: | 30 |
Molecular Structure: | |
Formula: | C11H14Cl N |
Molecular Weight: | 195.692 |
Synonyms: | (?à)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine;8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; |
EINECS: | 1312995-182-4 |
Density: | 1.075g/cm3 |
Boiling Point: | 288ºC |
Flash Point: | 128 ºC |
PSA: | 12.03000 |
LogP: | 2.91800 |
1-((2-(4-chlorophenyl)ethyl)amino)-2-chloropropane hydrochloride
(+/-)-Lorcaserin
Conditions | Yield |
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With aluminum (III) chloride In 1,2-dichloro-benzene at 120 - 125℃; Inert atmosphere; | 99% |
With aluminum (III) chloride at 120 - 125℃; for 3h; Inert atmosphere; Large scale; | 97% |
With aluminum (III) chloride In 1,2-dichloro-benzene at 135 - 140℃; | 96.1% |
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃; for 4h; Solvent; Temperature; Reagent/catalyst; Friedel-Crafts Alkylation; Inert atmosphere; Large scale; | 92.3% |
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃; Friedel-Crafts Alkylation; | 84.5% |
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃; | 84.5% |
With zinc(II) chloride at 125℃; for 6.41667h; Reagent/catalyst; Friedel-Crafts Alkylation; | 230 mg |
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃; Friedel-Crafts Alkylation; | 83.9% |
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃; | 83.9% |
N-(4-chlorophenylethyl)propyl-2-ene-1-amine
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With aluminum (III) chloride In 1,2-dichloro-benzene at 90℃; Friedel-Crafts Alkylation; | 82.1% |
With aluminum (III) chloride at 125℃; for 6.41667h; Friedel-Crafts Alkylation; | 230 mg |
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With aluminum (III) chloride In chlorobenzene at 110℃; Solvent; Temperature; | 81.6% |
Multi-step reaction with 2 steps 1: hydrogenchloride / ethyl acetate / 20 °C / pH 2 / Large scale 2: aluminum (III) chloride / 1,2-dichloro-benzene / 4 h / 110 °C / Inert atmosphere; Large scale View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / ethyl acetate / 20 °C 2: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C View Scheme | |
Multi-step reaction with 2 steps 1: dichloromethane / 25 °C 2: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / water; ethyl acetate / 20 °C 2: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C View Scheme |
8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With borane-THF at 20℃; for 10h; | 70% |
With borane In diethyl ether | |
With sodium tetrahydroborate; chloro-trimethyl-silane In 1,2-dichloro-ethane at 70℃; for 20h; Solvent; Temperature; Cooling with ice; | 0.89 g |
N-(4-chlorophenylethyl)-2-chloropropanamide
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: AlCl3 / 150 - 200 °C 2: BH3 / diethyl ether View Scheme | |
Multi-step reaction with 2 steps 1: aluminum (III) chloride / 8 h / 150 °C 2: chloro-trimethyl-silane; sodium tetrahydroborate / 1,2-dichloro-ethane / 20 h / 70 °C / Cooling with ice View Scheme |
4-chlorophenylethylamine
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine / CH2Cl2 2: AlCl3 / 150 - 200 °C 3: BH3 / diethyl ether View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / tetrahydrofuran / 18 h / 20 °C 2: zinc(II) chloride / 6.42 h / 125 °C View Scheme | |
Multi-step reaction with 4 steps 1: dmap / dichloromethane / 0 - 20 °C / Large scale 2: potassium carbonate; potassium hydroxide; tetrabutylammomium bromide / toluene / 5 h / 80 °C / Large scale 3: hydrogenchloride / ethyl acetate / 20 °C / pH 2 / Large scale 4: aluminum (III) chloride / 1,2-dichloro-benzene / 4 h / 110 °C / Inert atmosphere; Large scale View Scheme |
(1R,S)-N-trifluoroacetyl-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With sodium hydroxide In methanol at 60℃; for 3.5h; | 35 mg |
With sodium hydroxide In methanol | |
With sodium hydroxide In methanol; water at 60℃; for 3.5h; |
1-((2-(4-chlorophenyl)ethyl)amino)-2-chloropropane hydrochloride
1,2-dichloro-benzene
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Stage #1: 1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride; 1,2-dichloro-benzene With aluminum (III) chloride at 126℃; for 16h; Friedel Crafts; Industry scale; Inert atmosphere; Stage #2: With sodium hydroxide In cyclohexane; water pH=12; Product distribution / selectivity; Industry scale; |
Product Name: LorcaserinA
Synonyms of LorcaserinA (CAS NO.616201-80-0): 8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine
CAS NO: 616201-80-0
Molecular Formula of LorcaserinA (CAS NO.616201-80-0): C11H14ClN
Molecular Weight: 195.69
Molecular Structure:
Boiling Point: 288 º C
Density of LorcaserinA (CAS NO.616201-80-0): 1.075g/cm3
Flash Point: 128 º C