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62-74-8

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Basic Information
CAS No.: 62-74-8
Name: SODIUM FLUOROACETATE
Article Data: 5
Molecular Structure:
Molecular Structure of 62-74-8 (SODIUM FLUOROACETATE)
Formula: C2H3 F O2 . Na
Molecular Weight: 100.025
Synonyms: Aceticacid, fluoro-, sodium salt (8CI,9CI);1080;Compound 1080;Fluoroacetic acidsodium salt;Fratol;Furatol;Ratbane 1080;SMFA;Sodium fluoroacetate;Sodiummonofluoroacetate;Tenate;
EINECS: 200-548-2
Melting Point: 200-205 °C (dec.)
Boiling Point: 167.9°C at 760 mmHg
Flash Point: 55.3°C
Solubility: Very soluble
Appearance: white odourless hygroscopic powder
Hazard Symbols: Toxic by ingestion, inhalation, and skin absorption. TLV: 0.05 mg/m3; STEL 0.15 mg/m3. Toxic by skin absorption. For use by trained operators only, use has been restricted.
Risk Codes: 26/27/28-50
Safety: A deadly human poison by ingestion. Experimental poison by ingestion, skin contact, intraperitoneal, subcutaneous, and intravenous routes. A very highly toxic water-soluble salt used mainly as an immediate-action rodenticide. It is absorbed rapidly by the gastrointestinal tract but slowly by the skin unless the skin is abraded or cut. It operates by blocking the Krebs cycle by formation of fluorocitric acid, which inhibits aconitase. It has an effect on either the cardiovascular or nervous system, or both, in all species and, in some species, the skeletal muscles. Humans have mixed responses, with the cardiac feature predominating. By a direct action on the heart, contractile power is lost, which leads to declining blood pressure. Ventricular premature contractions and arrhythmias are seen in all species, including humans. The central nervous system is directly attacked by sodium fluoroacetate. In humans, the action on the central nervous system produces epileptiform convulsive seizures followed by severe depression. The dangerous dose for humans is 0.5–2 mg/kg. Other species vary considerably in their response to this material, with primates and birds being the most resistant and carnivora and rodents being the most susceptible. Most domestic animals show a susceptibility falling between the two extremes indicated above. Experimental reproductive effects. When heated to decomposition it emits highly toxic fumes of Na2O and F.
PSA: 40.13000
LogP: -1.29420
Raw Materials
459-72-3
51-21-8
Downstream Products
144-49-0
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Consensus Reports

Reported in EPA TSCA Inventory. EPA Extremely Hazardous Substances List.

Standards and Recommendations

OSHA PEL: TWA 0.05 mg/m3 (skin); STEL 0.15 mg/m3 (skin)
ACGIH TLV: TWA 0.05 mg/m3 (skin)
DFG MAK: 0.05 mg/m3
DOT Classification:  6.1; Label: Poison

Specification

The Sodium fluoroacetate, with the CAS registry number 62-74-8,is also known as Monofluoressigsaures natrium . It belongs to the product categories of Organic matters. This chemical's molecular formula is C2H2FNaO2 and Its EINECS number is 200-548-2.What's more,Its systematic name is Sodium fluoroacetate .It is a fine,white,odorless,powdered solid, which is air & water reactions water soluble. It is used as a rodenticide. It is used as kill rat poison and toxic to humans and animals.And it can be derived from hydrolysis of fluoroacetamide with sodium hydroxide .

Physical properties about Sodium fluoroacetate are:
(1)ACD/LogP:  -0.226; (2)# of Rule of 5 Violations:  0; (3)ACD/LogD (pH 5.5):  -3.05; (4)ACD/LogD (pH 7.4):  -3.94; (5)ACD/BCF (pH 5.5):  1.00; (6)ACD/BCF (pH 7.4):  1.00; (7)ACD/KOC (pH 5.5):  1.00; (8)ACD/KOC (pH 7.4):  1.00; (9)#H bond acceptors:  2; (10)#H bond donors:  1; (11)#Freely Rotating Bonds:  1; (12)Flash Point:  55.3 °C; (13)Enthalpy of Vaporization:  44.59 kJ/mol; (14)Boiling Point:  167.9 °C at 760 mmHg; (15)Vapour Pressure:  0.828 mmHg at 25°C

You can still convert the following datas into molecular structure:
(1)SMILES:[Na+].[O-]C(=O)CF;
(2)Std. InChI:InChI=1S/C2H3FO2.Na/c3-1-2(4)5;/h1H2,(H,4,5);/q;+1/p-1;
(3)Std. InChIKey:JGFYQVQAXANWJU-UHFFFAOYSA-M;

Safety Information of Sodium fluoroacetate:
The Sodium fluoroacetate is Very toxic to aquatic organisms. So avoid release to the environment. Refer to special instructions / safety data sheets. When you use it ,keep away from food, drink and animal foodstuffs,and do not breathe dust. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) .

The toxicity data of Sodium fluoroacetate as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 intraperitoneal 102mg/kg (102mg/kg)   Australian Wildlife Research. Vol. 15, Pg. 239, 1988.
bird - wild LD50 oral 2370ug/kg (2.37mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
bird - wild LD50 subcutaneous 630ug/kg (.63mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ATAXIA
Australian Wildlife Research. Vol. 11, Pg. 373, 1984.
cat LD50 intraperitoneal 300ug/kg (.3mg/kg)   American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946.
cat LD50 oral 350ug/kg (.35mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 37, Pg. 307, 1948.
chicken LDLo oral 5900ug/kg (5.9mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 36, Pg. 59, 1947.
dog LD50 intravenous 60ug/kg (.06mg/kg)   Yakkyoku. Pharmacy. Vol. 31, Pg. 1385, 1980.
dog LD50 oral 66ug/kg (.066mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 82, 1951.
domestic animals - goat/sheep LD50 intramuscular 700ug/kg (.7mg/kg)   American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946.
domestic animals - goat/sheep LD50 intraperitoneal 200ug/kg (.2mg/kg)   American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946.
domestic animals - goat/sheep LD50 oral 500ug/kg (.5mg/kg) CARDIAC: OTHER CHANGES Australian Wildlife Research. Vol. 9, Pg. 487, 1982.
domestic animals - goat/sheep LDLo intravenous 519ug/kg (.519mg/kg) ENDOCRINE: HYPERGLYCEMIA

MUSCULOSKELETAL: OTHER CHANGES

LIVER: OTHER CHANGES
Journal of Comparative Pathology and Therapeutics. Vol. 70, Pg. 145, 1960.
duck LD50 oral 4810ug/kg (4.81mg/kg)   Toxicology and Applied Pharmacology. Vol. 22, Pg. 556, 1972.
frog LD50 subcutaneous 1gm/kg (1000mg/kg)   American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946.
frog LDLo oral 54mg/kg (54mg/kg)   Veterinary and Human Toxicology. Vol. 15, Pg. 6, 1973.
guinea pig LD50 intraperitoneal 378ug/kg (.378mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 62, 1949.
guinea pig LD50 oral 300ug/kg (.3mg/kg)   American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946.
guinea pig LD50 skin 1600ug/kg (1.6mg/kg) CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 182, 1969.
guinea pig LD50 subcutaneous 250ug/kg (.25mg/kg)   Biochemical Pharmacology. Vol. 6, Pg. 169, 1961
horse/donkey LD50 unreported 1mg/kg (1mg/kg)   American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946.
human LDLo oral 714ug/kg (.714mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 542, 1969.
mammal (species unspecified) LD50 intraperitoneal 100ug/kg (.1mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 36, Pg. 59, 1947.
mammal (species unspecified) LD50 oral 110ug/kg (.11mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Australian Wildlife Research. Vol. 8, Pg. 385, 1981.
man LDLo unreported 5mg/kg (5mg/kg) CARDIAC: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946.
monkey LD50 intravenous 5mg/kg (5mg/kg)   American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946.
monkey LD50 oral 300mg/kg (300mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 182, 1969.
mouse LD50 intraperitoneal 7mg/kg (7mg/kg)   Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. Vol. 34, Pg. 193, 1979.
mouse LD50 oral 100ug/kg (.1mg/kg)   Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977.
mouse LD50 skin 25300ug/kg (25.3mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 182, 1969.
mouse LD50 subcutaneous 7200ug/kg (7.2mg/kg)   National Defense Research Committee, Office of Scientific Research and Development, Progress Report.Vol. 30101, Pg. 2, 1945.
mouse LD50 unreported 10mg/kg (10mg/kg)   Yakkyoku. Pharmacy. Vol. 30, Pg. 397, 1979.
pig LD50 intraperitoneal 300ug/kg (.3mg/kg)   American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946.
pigeon LD50 oral 2mg/kg (2mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 36, Pg. 59, 1947.
quail LD50 oral 18mg/kg (18mg/kg)   Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971.
rabbit LD50 intravenous 300ug/kg (.3mg/kg)   American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946.
rabbit LD50 oral 340ug/kg (.34mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Australian Wildlife Research. Vol. 9, Pg. 487, 1982.
rabbit LD50 subcutaneous 281ug/kg (.281mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 62, 1949.
rat LD50 intraperitoneal 1940ug/kg (1.94mg/kg)   British Journal of Experimental Pathology. Vol. 50, Pg. 277, 1969.
rat LD50 oral 100ug/kg (.1mg/kg)   American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946.
rat LD50 skin 48mg/kg (48mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 182, 1969.
rat LD50 unreported 15mg/kg (15mg/kg)   Yakkyoku. Pharmacy. Vol. 30, Pg. 397, 1979.
squirrel LD50 intraperitoneal 400ug/kg (.4mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 36, Pg. 59, 1947.
squirrel LD50 oral 300ug/kg (.3mg/kg)   American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946.